Investigation of the Dose Distribution of 32P Skin Patch Source by GAMOS Monte Carlo Simulation

Öz

In recent years, both experimental and theoretical studies on superficial brachytherapy for the treatment of skin cancers have been increasing. The results of experimental and theoretical studies show that the method is promising. The method involves the use of beta-emitting radionuclides. It is crucial to thoroughly understand and investigate the dose characteristics of the radionuclides used for the success of the treatment. In this study, the percent depth dose and transverse dose profiles of the commonly used cancer treatment, the 32P-labeled skin patch source, were examined using the GAMOS Monte Carlo Simulation method. The simulation results obtained are consistent with studies in the literature. The examined 12.5 mm radius skin patch source is suitable for the treatment of skin tumors with sizes ranging from 9.0 to 11.0 mm. By appropriately matching the size of the skin patch source to the size of the skin tumor, both the normal tissue surrounding the tumor and the normal tissue, cartilage, and bone beneath the tumor can be preserved. The 32P skin patch source will be a suitable option for early-stage tumors with a thickness of 1.0-2.0 mm that have not yet reached the deeper layers of the skin tissue. For deeper tumors, radionuclides emitting high-energy beta particles should be utilized.

Anahtar Kelimeler

• Phosphorus-32
• GAMOS
• Superficial Brachytherapy
• Skin Patches
• Radionuclide

32P Cilt Yama Kaynağının Doz Dağılımının GAMOS Monte Carlo Simülasyonu İle İncelenmesi

Öz

Son yıllarda cilt kanserlerinin tedavisinde yüzeysel brakiterapiye yönelik hem deneysel hem de teorik çalışmalar artmaktadır. Deneysel ve teorik çalışmaların sonuçları, yöntemin umut verici olduğunu göstermektedir. Yöntem, beta yayan radyonüklitlerin kullanımını içerir. Tedavinin başarısı için kullanılan radyonüklitlerin doz özelliklerinin iyice anlaşılması ve araştırılması büyük önem taşımaktadır. Bu çalışmada yaygın olarak kanser tedavisinde kullanılan 32P etiketli yama kaynağının yüzde derinlik dozu ve enine doz profilleri GAMOS Monte Carlo Simülasyon yöntemi kullanılarak incelenmiştir. Elde edilen simülasyon sonuçları literatürdeki çalışmalarla tutarlıdır. İncelenen 12,5 mm yarıçaplı cilt yaması kaynağı, boyutları 9,0 ile 11,0 mm arasında değişen cilt tümörlerinin tedavisi için uygundur. Cilt yama kaynağının boyutunun cilt tümörünün boyutuna uygun şekilde eşleştirilmesiyle, hem tümörü çevreleyen normal doku hem de tümörün altındaki normal doku, kıkırdak ve kemik korunabilir. 32P cilt yama kaynağı, henüz cilt dokusunun daha derin katmanlarına ulaşmamış, 1,0-2,0 mm kalınlığındaki erken evre tümörler için uygun bir seçenek olacaktır. Daha derin tümörler için yüksek enerjili beta parçacıkları yayan radyonüklitlerden yararlanılmalıdır.

Anahtar Kelimeler

• Fosfor-32
• GAMOS
• Yüzeysel Brakiterapi
• Deri Yamaları
• Radyonüklid

Kaynakça

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