Bazı Dioksaborepin Türevlerinin Sentezi ve Antimikrobiyal Aktivite Tayini

Öz

Bu çalışmanın amacı, bazı dioksaborepin bileşiklerini (2a-c) sentezlemek ve (2a) bileşiği için çeşitli mikroorganizmalara karşı antimikrobiyal aktivite sonuçlarını değerlendirmektir. Mikrodilüsyon yöntemi için Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 25923), Echerichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Streptococcus mutans (ATCC 25175) ve Candida albicans (ATCC 90028) kullanılmıştır. Dioksaborepin bileşiği (2a) özellikle hastane enfeksiyonuna neden olabilen P. aeruginosa‘ya karşı iyi sonuç vermiştir. Dioksaborepin bileşiği (2a) Gram negatif ve Gram pozitif bakteriler ve mantara karşı aktivite göstermiştir. Bu çalışmadaki sonuçlara göre günümüzde, bor içeren yeni bileşiklerin sentezi ve aktivite testleri önemli bir yer tutmaktadır. Bu tür bileşikler geliştirilebilir ve gelecekte daha etkili, yeni antibakteriyel ve antifungal madde tasarımında kullanılabilirler.

Anahtar Kelimeler

• Antimikrobiyal aktivite
• Bor
• Dioksaborepin bileşikleri

Synthesis of Some Dioxaborepine Derivatives and Determination of Antimicrobial Activity

Öz

The aim of this study, synthesis of some dioxaborepine compounds (2a-c) and for compound (2a) evaluation of antimicrobial activity results against several microorganisms. Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 25923), Echerichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Streptococcus mutans (ATCC 25175) and Candida albicans (ATCC 90028) were used for the microdilution method. Dioxaborepine compound (2a) has been good result against particularly P. aeruginosa which is causing a nosocomial infection. Dioxaborepine compound (2a) showed activity against Gram negative and Gram positive bacteria and fungi. For the results of this study, nowadays, synthesis of boron, including new compounds and their activity tests has an importance. Such compounds can be improved and used for the design of more potent, a new class of antibacterial and antifungal agents in the future.

Anahtar Kelimeler

• Antimicrobial activity
• Boron
• Dioxaborepine compounds

Kaynakça

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