Araştırma Makalesi
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Adverse Reactions To Blue Dye Injections During Sentinel Lymph Node Biopsy

Yıl 2017, Cilt: 31 Sayı: 2, 81 - 85, 23.08.2017

Öz

Objective: Sentinel lymph
node biopsy for breast cancer surgical treatment has been used as an
alternative of axillary dissection in most cases. The aim of our study is to
report the rate of adverse reactions during sentinel lymph node biopsies in
early stage (T1-T2, N0, M0) breast cancer patients.

Material and method: We retrospectively reviewed 1374 consecutive SLNBs patients for early
stage breast cancer between May 1998 and April 2017 in our clinic.

Results: Blue dye was
used in SLN biopsies in 315 patients. An allergic reaction occurred in 12 of
these patients (0.4%). The patients' stay in the hospital did not change and
they received adjuvant treatment without delay.

Conclusion: Sentinel
lymph node biopsy can be performed using only radioactive colloid injection to
protect against the allergic reactions caused by the blue dye. Deep parenchymal
injections may be preferred instead of intradermal injections due to toxic
effects on the tissue in cases where blue dye should be applied.

Kaynakça

  • Referans1 Newman EA, Newman LA. Lymphatic mapping tecniques and Sentinel lymph node biopsy in breast cancer. Surg Clin N Am 2007;87:353-364.
  • Referans2 Sanghani M, Balk EM, Cady B. Impact of axillary lymph node dissection on breast cancer outcome in clinically node negative patients. Cancer 2009;115:1613-1620.
  • Referans3 Fisher B, Wolmark N, Bauer M, et al. The accuracy of clinical nodal staging and of limited axillary dissection as a determinant of histologic nodal status in carcinoma of the breast. Surg Gynecol Obstet 1981;152:765–72.
  • Referans4 Reger V, Beito G, Jolly PC. Factors affecting the incidence of lymph node metastases in small cancers of the breast. Am J Surg 1989;157:501–2.
  • Referans5 Dowlatshahi K, Snider HC, Kim R. Axillary node status in nonpalpable breast cancer. Ann Surg Oncol 1995;2:424–8.
  • Referans6 Nwariaku FE, Euhus DM, Beitsch PD, et al. Sentinel lymph node biopsy, an alternative to elective axillary dissection for breast cancer.Am J Surg 1998;176:529–31.
  • Referans7 Tanis PJ, Nieweg OE, Olmos RAV, Rutgers EJ, Kroon BR. History of sentinel lymph node and validation of the technique. Breast Cancer Res 2001;3:109-112.
  • Referans8 Chen SL, Iddings DM, Scherri RP Bilchik AJ. Lymphatic mapping and sentinel node analysis:current concepts and applications. CA Cancer J Clin 2006;56:293-309.
  • Referans9 Filippakis GM, Zografos G. Contraindications of sentinel lymph node biopsy: Are there any really? W J Surg Oncol 2007;5:10-21.
  • Referans10 Kim T, Giuliano AE, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in early stage breast carcinoma. A metaanalysis. Cancer 2006;106:4-16.
  • Referans11 Masamat Y, Shenoy H, Speirs V, Hnaby A, Horgan K. Properties and characteristics of the dyes injected to asist axillary sentinel lymph node localization in breast surgery. Eur J Surg Oncol 2006;32:381-384.
  • Referans12 Parvaiz MA, Isgar B. Anaphylaxis and blue urticaria associatedwith patent blue V injection. Anaesthesia. 2012;67:1275-6.
  • Referans13 Howard JD, Moo V, Sivalingam P. Anaphylaxis and other adversereactions to blue dyes: a case series. Anesth Intensive Care. 2011;39:287-92.
  • Referans14 Brenet O, Lalourcey L, Queinnec M, et al. Hypersensitivity reac-tions to Patent Blue V in breast cancer surgery: a prospectivemulticentre study. Acta Anesthesiol Scand. 2013;57:106-11.
  • Referans15 Shinzato JY, Marcaccini ACP, Brag AFA, et al. Reac¸ão anafiláticaao corante azul patente durante biopsia do linfonodo sentinelaem câncer de mama inicial - Relato de caso. Rev Bras Ginecol Obstet. 2006;28:728-32.
  • Referans16 Del Massa EC, Grion LFC, Ghaname NS. Reac¸ão alérgica ao azulpatente. São Paulo Med J. 2005;123:53.
  • Referans17 Tripathy S, Nair PV. Adverse drug reaction, patent blue V dye and anaesthesia. Indian J Anaesth. 2012;56:563-6. Referans18 Albo D, Wayne JD, Hunt KK, Rahlfs TF, Singletary SE, Ames FC, Feig BW, Ross MI, Kuerer HM. Anaphlactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. Am J Surg 2001;182:393-8.
  • Referans19 Stradling BS, Aranha G, Gabram S. Adverse skin lesions after methylene blue injections for sentinel lymph node localization. Am J Surg 2002;184:350-52.

Sentinel lenf nodu örneklemesi esnasında uygulanan boya sonucunda görülen yan etkiler

Yıl 2017, Cilt: 31 Sayı: 2, 81 - 85, 23.08.2017

Öz

Amaç: Sentinel lenf
nodu biyopsisi pek çok meme kanserli hastanın cerrahi tedavisi için aksiller
lenf nodu diseksiyonuna alternatif olarak uygulanabilir. Çalışmamızın amacı,
erken evre (T1-T2, N0, M0 ) meme kanserli hastalarda radyokolloid enjeksiyonu
ile kombine veya tek başına mavi boya kullanılarak yapılan sentinel lenf nodu
biyopsilerinde karşılaştığımız yan etkileri bildirmektir.



Gereç
ve yöntem:

Kliniğimizde erken evre meme kanseri nedeni ile Mayıs 1998 - Nisan 2017
tarihleri arasında yapılmış 1374 adet sentinel lenf nodu biyopsisi sonuçları
retrospektif olarak incelendi.



Bulgular: Sentinel lenf
nodu biyopsisi yapılan hastalardan 315 tanesinde boya kullanıldı. Bu hastaların
12 tanesinde (%0,4) alerjik reaksiyon görüldü. Hastaların hastanede kalış
sürelerinde değişiklik olmadı ve adjuvan tedavilerini gecikme olmaksızın
aldılar.



Sonuç: Mavi boyanın yol
açtığı alerjik reaksiyonlardan korunmak için sadece radyoizotop ile işlem
yapılabilir. Mavi boya uygulanması gereken olgularda ise doku üzerindeki toksik
etkilerinden ötürü intradermal enjeksiyonlar yerine derin parankimal
enjeksiyonlar tercih edilebilir.

Kaynakça

  • Referans1 Newman EA, Newman LA. Lymphatic mapping tecniques and Sentinel lymph node biopsy in breast cancer. Surg Clin N Am 2007;87:353-364.
  • Referans2 Sanghani M, Balk EM, Cady B. Impact of axillary lymph node dissection on breast cancer outcome in clinically node negative patients. Cancer 2009;115:1613-1620.
  • Referans3 Fisher B, Wolmark N, Bauer M, et al. The accuracy of clinical nodal staging and of limited axillary dissection as a determinant of histologic nodal status in carcinoma of the breast. Surg Gynecol Obstet 1981;152:765–72.
  • Referans4 Reger V, Beito G, Jolly PC. Factors affecting the incidence of lymph node metastases in small cancers of the breast. Am J Surg 1989;157:501–2.
  • Referans5 Dowlatshahi K, Snider HC, Kim R. Axillary node status in nonpalpable breast cancer. Ann Surg Oncol 1995;2:424–8.
  • Referans6 Nwariaku FE, Euhus DM, Beitsch PD, et al. Sentinel lymph node biopsy, an alternative to elective axillary dissection for breast cancer.Am J Surg 1998;176:529–31.
  • Referans7 Tanis PJ, Nieweg OE, Olmos RAV, Rutgers EJ, Kroon BR. History of sentinel lymph node and validation of the technique. Breast Cancer Res 2001;3:109-112.
  • Referans8 Chen SL, Iddings DM, Scherri RP Bilchik AJ. Lymphatic mapping and sentinel node analysis:current concepts and applications. CA Cancer J Clin 2006;56:293-309.
  • Referans9 Filippakis GM, Zografos G. Contraindications of sentinel lymph node biopsy: Are there any really? W J Surg Oncol 2007;5:10-21.
  • Referans10 Kim T, Giuliano AE, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in early stage breast carcinoma. A metaanalysis. Cancer 2006;106:4-16.
  • Referans11 Masamat Y, Shenoy H, Speirs V, Hnaby A, Horgan K. Properties and characteristics of the dyes injected to asist axillary sentinel lymph node localization in breast surgery. Eur J Surg Oncol 2006;32:381-384.
  • Referans12 Parvaiz MA, Isgar B. Anaphylaxis and blue urticaria associatedwith patent blue V injection. Anaesthesia. 2012;67:1275-6.
  • Referans13 Howard JD, Moo V, Sivalingam P. Anaphylaxis and other adversereactions to blue dyes: a case series. Anesth Intensive Care. 2011;39:287-92.
  • Referans14 Brenet O, Lalourcey L, Queinnec M, et al. Hypersensitivity reac-tions to Patent Blue V in breast cancer surgery: a prospectivemulticentre study. Acta Anesthesiol Scand. 2013;57:106-11.
  • Referans15 Shinzato JY, Marcaccini ACP, Brag AFA, et al. Reac¸ão anafiláticaao corante azul patente durante biopsia do linfonodo sentinelaem câncer de mama inicial - Relato de caso. Rev Bras Ginecol Obstet. 2006;28:728-32.
  • Referans16 Del Massa EC, Grion LFC, Ghaname NS. Reac¸ão alérgica ao azulpatente. São Paulo Med J. 2005;123:53.
  • Referans17 Tripathy S, Nair PV. Adverse drug reaction, patent blue V dye and anaesthesia. Indian J Anaesth. 2012;56:563-6. Referans18 Albo D, Wayne JD, Hunt KK, Rahlfs TF, Singletary SE, Ames FC, Feig BW, Ross MI, Kuerer HM. Anaphlactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. Am J Surg 2001;182:393-8.
  • Referans19 Stradling BS, Aranha G, Gabram S. Adverse skin lesions after methylene blue injections for sentinel lymph node localization. Am J Surg 2002;184:350-52.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Bölüm Makaleler
Yazarlar

Ali İbrahim Sevinç Bu kişi benim

Süleyman Özkan Aksoy Bu kişi benim

Merih Güray Durak

Yayımlanma Tarihi 23 Ağustos 2017
Gönderilme Tarihi 23 Mayıs 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 31 Sayı: 2

Kaynak Göster

Vancouver Sevinç Aİ, Aksoy SÖ, Güray Durak M. Sentinel lenf nodu örneklemesi esnasında uygulanan boya sonucunda görülen yan etkiler. DEU Tıp Derg. 2017;31(2):81-5.