Isolated neuro-Behçet’s disease in a child, from headache to diagnosis: A case report

Öz

Isolated neuro-Behçet’s disease in a child, from headache to diagnosis: A case report

Öz

Behçet's disease (BD) is an immuno-inflammatory multi-systemic disease characterized by ophthalmological and skin involvement, also oral and genital ulcers. Its etiology and pathogenesis are not clearly known. Neuro-Behçet's disease can occur as an isolated form or a rare complication of BD. Besides, diagnosis of neuro-Behçet's disease is difficult. Since Neuro-Behçet can result in morbidity and mortality, early diagnosis and treatment are important. The most important genetic factor in the pathogenesis of BD is Human Leucocyte Antigen (HLA-B 51) allele positivity. A 9-year-old girl was brought to our outpatient clinic for 6 months with a migraine-like headache. The headache of the patient has a partial response to analgesics and rarely awakes from sleep at night accompanied by vomiting. The patient was diagnosed with an isolated neuro-Behçet's disease by HLA-B 51 allele positivity and brain magnetic resonance imaging (MRI) findings. In the current study, the roles of HLA-B 51 allele positivity and brain MRI findings were discussed in the diagnosis of neuro-Behçet's disease.

Anahtar Kelimeler

• HLA-B51 positivity
• Isolated neuro-Behçet
• Migrain like headache; MRI.

Kaynakça

1. 1.Behçet H. Uber residivierende, aphtosedurcheinVirus verursachte Geschwure am Mund, am Augeund an den Genitalien. DermWschr. 1937; 105:1152-57.
2. 2. Saip S, Akman DG, Siva A. Neuro-Behçet syndrome. HandbClin Neurol. 2014; 121: 1703-23.
3. 3.Knapp P. Beitragzur symptomatologie undtherapie der rezidivieren den hypopyoniritis undder begleiten denaphtozenschleimhauterkrankungen. Schweiz MedWochenschr. 1941; 71: 1288-90.
4. 4.Davatchi F. Diagnosis/classification criteria forBehçet’s disease. Patholog Res Int. 2012; 2012:607921.