Burn wound bacterial profile and antibiotic sensitivity results in Turkey’s southeast region of Anatolia

Öz

Introduction: The conducted study was done to reveal the profile of bacteria isolated from wound sites of patients hospitalized in our burn center. We also aimed to find the appropriate sensitive antibiotics for use in the treatment. Methods: In the study, we examined 394 patients with (+) wound cultures reports from the 1,415 patients hospitalized at the Gazi Yaşargil Training and Research Hospital Burn Center between January 2010 and January 2020. Results: From 394 patients, 217 (55%) were male and 177 (45%) were female. The average age of patients was 12.86 ± 17.34 (min 1 - max: 94 years). In the wound culture results, bacteria were 70.55% gram-pozitive and 28.68% gram-negative Candida albicans was found in wound culture growth at a rate of 0.07%. The most common gram (+) pathogen was Staphylococcus aureus at 23.09% (n = 91). The most common gram (-) pathogens were Escherichia coli at 9.13% (n = 36) and Pseudomonas aeruginosa at 9.13% (n = 36). Conclusion: As a result of our study, we found that the most common causes of burn infections in our region were due to S. aureus, E. coli, and P. aeruginosa, We hope that the use of broad spectrum antibiotics can be effective against these bacteria and will contribute to clinical treatments until culture reports are available.

Anahtar Kelimeler

• Burn
• Wound
• Microbiological culture results
• Antibiotics

Kaynakça

1. 1.Burns. (2018). Accessed: May 27, 2019: http://www.who.int/news-room/factsheets/detail/burns.
2. 2.GBD 2015 Disease and Injury Incidence and PrevalenceCollaborators: Global, regional, and national incidence,prevalence, and years lived with disability for 310 diseasesand injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016,388:1545-602.10.1016/S0140-6736(16)31678-6
3. 3.Pruitt BA Jr, McManus AT, Kim SH, et al: Burn woundinfections: Current status .World J Surg. 1998, 22:135-45.10.1007/s002689900361
4. 4.Weber JM, McManus AT, Nursing Committee of the International Society for Burn Injuries: Infection control inburn patients. Burns. 2004, 30: A16-24.10.1016/j.burns.2004.08.003
5. 5.Farina JA, Rosique MJ, Rosique RG: Curbing inflammationin burn patients. Int J Inflam. 2013, 2013:715645. 10.1155/2013/715645
6. 6.Church D, Elsayed S, Reid O, et al: Burn wound infections.Clin Microbiol Rev. 2006, 19:403-34.10.1128/CMR.19.2.403-434.2006
7. 7. Raz-Pasteur A, Hussein K, Finkelstein R, et al: Blood streaminfections (BSI) in severe burn patients--early and late BSI: a 9-yearstudy. Burns. 2013, 39:636-42. 10.1016/j.burns.2012.09.015
8. 8.Burn Wound Infections. (2011). Accessed: August 31, 2013:http://search.medscape.com/search/?q=Burn%20Wound%20Infections.

9. 9.Fitzwater J, Purdue GF, Hunt JL, et al: The risk factors andtime course of sepsis and organ dysfunction after burntrauma. J Trauma. 2003, 54:959-66.10.1097/01.TA.0000029382.26295.AB
10. 10.Rafla K, Tredget E: Infection control in the burn unit .Burns. 2011, 37:5-15. 10.1016/j.burns.2009.06.198
11. 11.Weinstein RA, Mayhall CG: The epidemiology of burnwound infections: then and now . Clin Infect Dis. 2003,37:543-50. 10.1086/376993
12. 12.Antibiotic Resistance Threats in the United States, 2013.(2013). Accessed: December 25,2018:http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf.
13. 13.Demir Yiğit, Yasemin, and Ebral Yiğit. "Flame burns."Dermatologic therapy 34.6 (2021): e15133.
14. 14. Ventola CL: The antibiotic resistance crisis. Part 1: causesand threats . P T. 2015, 40:277-83.
15. 15.Greenhalgh DG, Saffle JR, Holmes JH 4th, et al.: American Burn Association consensus conference to define sepsis andinfection in burns. J Burn Care Res. 2007, 28:776-90. 10.1097/BCR.0b013e3181599bc9
16. 16. Datta S, Ghosh T, Sarkar D, et al: Bacteriological profile ofburn wounds and their antibiotic susceptibility pattern in atertiary care hospital. Int J Sci Stud. 2016, 4:141-45.
17. 17.Meroj A. Jasem et al. The most frequent bacterialinfections in burn injuries at burn units of two hospitals inBaghdad. Iraqi Journal of Public Health (2018) 2:1
18. 18.Saaiq M, Ahmad S, Zaib MS: Burn wound infections andantibiotic susceptibility patterns at Pakistan Institute ofMedical Sciences, Islamabad, Pakistan. World J Plast Surg.2015, 4:9 15.
19. 19.Chaudhary N A, Munawar M D, Khan M T, et al. (June 01,2019) Epidemiology, Bacteriological Profile, and AntibioticSensitivity Pattern of Burn Wounds in the Burn Unit of aTertiary Care Hospital. Cureus 11(6):e4794. DOI10.7759/cureus.4794.
20. 20.Tekin, R., et al. "The evaluation of patients with burnsduring fifteen years period." Clin Ter 164.5 (2013):385-9.
21. 21.“Central Asian and Eastern European Surveillance ofAntimicrobial Resistance. Annual report 2018”. http://www.euro.who.int/en/healthtopics/diseaseprevention/antimicrobialresistance/publications/2018/central-asian-andeastern-european-surveillance-of-antimicrobialresistance-annual-report-2018.
22. 22.Tekin, Recep, et al. "Risk factors for nosocomial burnwound infection caused by multidrug resistantAcinetobacter baumannii." Journal of Burn Care & Research35.1 (2014): e73-e80.
23. 23.Mehta M, Dutta P, Gupta V: Bacterial isolates from burnwound infections and their antibiograms: a eight-year study. Indian J Plast Surg. 2007, 40:25-28. 10.4103/0970-0358.32659
24. 24.Tekin, Recep, et al. "An evaluation of pediatric burnpatieints a fifteen-years period." Turkish Journal of Trauma and Emergency Surgery 18.6 (2012): 514-8.
25. 25.Mostaqimur Rahman, Hafiza Sultana , Md. AbdullahilMosawuir , Status of Extended Spectrum Beta-Lactamase (ESBL) Producing Bacteria Isolated from Surgical and BurnWound at Tertiary Care Hospital in Dhaka City, BangladeshJournal of Infectious Diseases June 2018, DOI:http://dx.doi.org/10.3329/bjid.v5i1.37712
26. 26. Air temperature in Turkey’s southeast region of Anatolia:www.mgm.gov.tr 2020.