Tractography Analysis of White Matter Pathways Associated with Speech Impairment in Parkinson's Disease

Öz

Purpose: Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting multiple systems. Speech disorders, stemming from motor and nonmotor deficits, affect up to 89% of PD patients. This study examines the arcuate fasciculus (AF) and frontal aslant tract (FAT), white matter pathways linked to verbal fluency, which have not been previously assessed in PD. Methods: We included publicly available high-quality diffusion-weighted images (DWI) acquired with 120 gradient directions (b = 2500 s/mm²) from 27 PD patients (Age: 66 ± 8, 14 M, 13 F) and 26 age-, sex-, and education-matched controls (Age: 64 ± 8, 14 M, 12 F), processed using the Generalized Q-sampling Imaging (GQI) model (DSI Studio software) for white matter pathway reconstruction. The Automatic Fiber Tracking (AutoTrack) option in DSI Studio was used for virtual dissection of the AF and FAT. Diffusion metrics of mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), fractional anisotropy (FA), quantitative anisotropy (QA), and track volume measures were obtained and analyzed. Results: No significant correlation was observed between quantitative anisotropy and verbal fluency measures across PD and control groups. However, male PD patients exhibited reduced left FAT volume and significantly lower QA in bilateral FAT and left AF. Microstructural changes in the FAT were observed in male PD patients, but no correlation was found between verbal fluency scores and QA. Conclusion: Our results suggest a more severe impact on the microstructure of the FAT in male PD patients compared to females.

Anahtar Kelimeler

• diffusion MRI
• parkinson
• arcuate fasciculus
• frontal aslant tract
• speech impairment

Kaynakça

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