Assessment of mean platelet volume in type 2 diabetics receiving insulin or oral antidiabetic agents

Öz

Objective: Increased mean platelet volume (MPV) is a known risk factor for various acute vascular complications, which is commonly associated with patients with diabetes mellitus (DM). This study was aimed to investigate the association of MPV, Type 2 DM and to know the difference of MPV in patients on oral hypoglycemic drugs and insulin therapy.

Methods: A total of 300 patients were selected and allocated to three subgroups with 100, as DM Group on insulin therapy, DM Group on oral hypoglycemic therapy and non-DM Group (Negative control Group). Investigations like fasting blood glucose, HbA1c and MPV were performed. The results of patient values were evaluated retrospectively.

Results: Results of the study showed that patients with type 2 DM have increased in the MPV. Oral antidiabetic treatment in patients MPV, was found to be higher compared to patients treated with insulin. The mean MPV in Group 1 (on oral hypoglycemic treatment) was 10.07±0.7 fl, in Group 2 (on Insulin therapy) 9.01±0.6 fl and in the controls Group 8.15±0.8 fl.

Conclusion: The outcome of study has shown that values of MPV are increased in patients with, Type 2 DM and are significantly higher in those patients on oral hypoglycemic therapy than patients on insulin therapy. MPV is a simple and cost-effective tool which can be explored for predicting the possibility of vascular events in patients suffering from diabetes mellitus. Early initiation of insulin treatment in confirmed cases of Type 2 diabetics not only helps in controlling blood glucose level but also helps in keeping MPV low and thereby preventing possibility of impending vascular events.

Key words: Mean platelet volume, type 2 diabetes mellitus, insulin therapy, oral hypoglycemic drugs

Anahtar Kelimeler

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Fatih Şahpaz1 Kemal Türker Ulutaş2

Öz

Amaç: Artmış Ortalama Trombosit Hacmi (OTH), Diabetes Mellitus (DM) hastalarında yaygın vasküler komplikasyonlarla yakından ilişkilidir. Bu çalışma OTH ile insulin tedavisi alan veya oral hipoglisemik tedavi alan hastaları kıyaslamayı amaçlamaktadır. Yöntemler: Çalışmaya randomize olarak seçilen 300 hasta 100 kişilik üç gruba ayrıldı: oral hipoglisemik tedavi alan grup-1, insulin tedavisi alan DM grup-2 ve non-DM sağlıklı grup-3. Tüm hastalardan açlık kan şekeri, HbA1c ve OTH ve biyokimya değerleri retrospektif olarak değerlendirildi.Bulgular: Çalışma sonucu OTH değerlerinin Tip 2 DM olan hastalarda artmış olduğu göstermiştir ve oral antidiyabetik tedavi alan hastalarda, insulin tedavisi alan hastalara göre daha yüksek olarak saptanmıştır. OTH değeri grup 1’de (oral hipoglisemik tedavi alan) 10.07±0.7fl, grup 2’de (İnsülin tedavisi alan) 9.01±0.6fl ve kontrol grubunda 8.15±0.8fl olarak tespit edildi. Sonuç: Çalışma sonucu DM hastası olgularda vasküler hastalık olasılığını tahmin etmek için OTH basit ve düşük maliyetli-etkin bir tanı aracı olarak kullanılabileceğini düşündürmektedir. Tip 2 diyabet doğrulanmış olgularda insulin tedavisinin erken başlanması sadece kan şekeri düzeyini kontrol etmede yardımcı olmaz; aynı zamanda OTH seviyesini düşük tutarak yaklaşan vasküler olayların olma olasılığını önlemeye yardımcı olabilir

Anahtar Kelimeler

• Ortalama trombosit hacmi, tip 2 diabetes mellitus, insülin tedavisi, oral hipoglisemik ilaçlar

Kaynakça

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