The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus

İlkay Demircan; Candan Özoğul; Seda Nur Akyol; Mustafa Necmi İlhan; Mustafa Kavutçu; Süreyya Barun; Mustafa Bilge; İbrahim Murat Hirfanoğlu

doi:10.5798/diclemedj.0921.2015.01.0521

The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus

Öz

Objective: At the present times uterus transplantation is an alternative therapy for women with untreatable uterine-based infertility factors. Before transplantation, the donor organ must stored in some solutions, but they may not adequate for protection. In this study, we investigated the potential protective effects of acetyl L-carnitine, added into histidine-tryptophanketoglutarate (HTK) solution, on rat uterus.

Methods: We divided 24 female Wistar Albino rats into four groups (n=6). Their uterine tissues were stored into four different solutions at different periods at 4oC ; Group 1 HTK, 4 hours; Group 2. HTK + acetyl L- carnitine, 4 hours, Group 3. HTK, 24 hours; Group 4. HTK + acetyl L- carnitine, 24 hours. Then tissues from uterus were used for histological and biochemical examination.

Results: In the study the number of TUNEL positive cells in group 4 was lower than group 3. Biochemically evaluated TBARS and NOS levels were highest in group 3 however CAT level was highest in group 2.

Conclusion: In conclusion, addition of acetyl L-carnitine to HTK solution reversed the histological alterations after 24 hours cold storage on rat uterus.

Anahtar Kelimeler

acetyl L-carnitine,uterus,transplantation,infertility

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Araştırma Makalesi

Yazarlar

İlkay Demircan Bu kişi benim

Candan Özoğul Bu kişi benim

Seda Nur Akyol Bu kişi benim

Mustafa Necmi İlhan Bu kişi benim

Mustafa Kavutçu Bu kişi benim

Süreyya Barun Bu kişi benim

Mustafa Bilge Bu kişi benim

İbrahim Murat Hirfanoğlu Bu kişi benim

Yayımlanma Tarihi

25 Aralık 2016

Gönderilme Tarihi

11 Ocak 2017

Kabul Tarihi

28 Kasım 2016

Yayımlandığı Sayı

Yıl 2016 Cilt: 43 Sayı: 4

DOI

https://doi.org/10.5798/diclemedj.0921.2015.01.0521

IZ

https://izlik.org/JA94KN92US

Kaynak Göster

RIS / Bibtex

APA

Demircan, İ., Özoğul, C., Akyol, S. N., İlhan, M. N., Kavutçu, M., Barun, S., Bilge, M., & Hirfanoğlu, İ. M. (2016). The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus. Dicle Medical Journal, 43(4), 561-568. https://doi.org/10.5798/diclemedj.0921.2015.01.0521

AMA

1.Demircan İ, Özoğul C, Akyol SN, vd. The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus. diclemedj. 2016;43(4):561-568. doi:10.5798/diclemedj.0921.2015.01.0521

Chicago

Demircan, İlkay, Candan Özoğul, Seda Nur Akyol, vd. 2016. “The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus”. Dicle Medical Journal 43 (4): 561-68. https://doi.org/10.5798/diclemedj.0921.2015.01.0521.

EndNote

Demircan İ, Özoğul C, Akyol SN, İlhan MN, Kavutçu M, Barun S, Bilge M, Hirfanoğlu İM (01 Aralık 2016) The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus. Dicle Medical Journal 43 4 561–568.

IEEE

[1]İ. Demircan vd., “The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus”, diclemedj, c. 43, sy 4, ss. 561–568, Ara. 2016, doi: 10.5798/diclemedj.0921.2015.01.0521.

ISNAD

Demircan, İlkay - Özoğul, Candan - Akyol, Seda Nur - İlhan, Mustafa Necmi - Kavutçu, Mustafa - Barun, Süreyya - Bilge, Mustafa - Hirfanoğlu, İbrahim Murat. “The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus”. Dicle Medical Journal 43/4 (01 Aralık 2016): 561-568. https://doi.org/10.5798/diclemedj.0921.2015.01.0521.

JAMA

1.Demircan İ, Özoğul C, Akyol SN, İlhan MN, Kavutçu M, Barun S, Bilge M, Hirfanoğlu İM. The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus. diclemedj. 2016;43:561–568.

MLA

Demircan, İlkay, vd. “The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus”. Dicle Medical Journal, c. 43, sy 4, Aralık 2016, ss. 561-8, doi:10.5798/diclemedj.0921.2015.01.0521.

Vancouver

1.İlkay Demircan, Candan Özoğul, Seda Nur Akyol, Mustafa Necmi İlhan, Mustafa Kavutçu, Süreyya Barun, Mustafa Bilge, İbrahim Murat Hirfanoğlu. The protective effects of acetyl L - carnitine which added into Histidine - Tryptophan - Ketoglutarate solution on donor uterus. diclemedj. 01 Aralık 2016;43(4):561-8. doi:10.5798/diclemedj.0921.2015.01.0521