Investigation of serum oxidative stress levels in patients with nasal polyps

Adnan Ekinci

doi:10.5798/dicletip.407237

Investigation of serum oxidative stress levels in patients with nasal polyps

Öz

Objective: To compare serum total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) levels between nasal polyp patients and heal thy subjects.

Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels.

Results: The mean TAS level was 1.248 mmol/L in the control group, it was 1.176 mmol/L in the patient group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006). Nasal polyp and control groups did not show any significant difference for PON1 (301.15 U/L vs. 295.75 U/L,p>0.05).

Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis compared it the control group. There was no significant difference between the patients with nasal polypand the control group in terms of the PON1 values.

Anahtar Kelimeler

Nasal Polyp,Total Oxidant Status,Total Antioxidant Status

Kaynakça

1. Koc C: Nazal Polip, otolaryngology, head and neck surgery. (Ed. Koc C), Ankara, Güneş bookstore 2004; 609–624.
2. Bateman ND, Fahy C, Woolford TJ. Nasal polyps: still more questions than answers. J Laryngol Otol. 2003; 117: 1–9.
3. Karlıdag T, İlhan N, Kaygusuz İ, Keles E, Yalçin S, Yildiz M. Roles of free radicals, nitricoxide and scavenging enzymes in nasal polyp development. Ann Otol Rhinol Laryngol. 2005; 114:122–6.
4. Uslu C, Taysı S, Bakan N. Lipid peroxidation and some antioxidant enzyme activities in experimental maxillary sinusitis. Ann Clin Lab Sci. 2003;33:18–22.
5. Norlander T, Westrin KM, Fukami M, Stierna P, Carlsöö B. Experimentally induced polyps in the sinus mucosa: a structural analysis of the initial stage. Laryngoscope. 1996; 106:196–203.
6. Si-es H. Oxidants and antioxidants. Exp Physiol. 1997; 82: 291-5.
7. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38: 1103-11.
8. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004; 37:112-19.

9. Ozdin M. Gursu M.F. Investigation of paraoxonase 1 and arylesterase activities and phenotypes in patients with coronary heart disease and various risk factors. Expertise Thesis, Fırat Universıty, Faculty of Medicine, Biochemistry Department, Elazıg, Turkey. 2003;17-19.
10. Durrington PN, Mackness B, Mackness MI. Paraoxonase and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2001;21:473-80.
11. Bozkus F, San, T. Ulas T, et al. Evaluation of total oxidative stress parameters in patients with nasal polyps. Acta Otorhinolaryngol Ital. 2013; 33:248-53.
12. Dogruer ZN, Unal M, Eskandari G, et al. Malon- dialdehyde and antioxidant enzymes in children with obstructive adenotonsillar hypertrophy. Clin Biochem. 2004; 37: 718–21.
13. Del Ben M, Fabiani M, Loffredo L, et al. Oxidative stress mediated arterial dysfunction in patients with obstructive sleep apnoea and the effect of continuous positive airway pressure treatment. BMC Pulm Med. 2012; 23:12–36.
14. Sandikci R, Turkmen S, Guvenen G, et al. Lipid peroxidation and antioxidant defence system in patients with active or inactive Behcet’s disease. Acta Derm Venereol. 2003; 83:342-6.
15. Hao W, Zhu Y, Meng L, Ni C, Yang J, Zhou H. Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp. Eur Arch Otorhinolaryngol. 2013; 270:1861–5.
16. Hartnell A, Heinemann A, Dolores M, et al. Identification of selective basophil chemo attractants in human nasal polyps as insulin-like growth factor–1 and insulin-like growth factor–2. J Immunol. 2004; 173:10,6448–57.
17. Daglı M, Eryılmaz A, Besler T, Akmansu H, Acar A, Korkmaz H. Role of free radicals and antioxidants in nasal polyps. Laryngoscope. 2004;114:1200–3.
18. Taysı S, Uslu C, Yılmaz A, Aktan A, Aktan B, Altas E. Lipid peroxidation and some antioxidant enzymes in nasal polyp tissue. Cell Biochem Funct. 2006; 24:461-5.
19. Cheng YK, Hwang GY, Lin CD, Tsai MH, Tsai SW, Chang WC. Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Laryngoscope. 2006;116:417-22.

Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Adnan Ekinci ^*
0000-0001-7725-8024
Türkiye

Yayımlanma Tarihi

17 Mart 2018

Gönderilme Tarihi

17 Mart 2018

Kabul Tarihi

11 Ocak 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 45 Sayı: 1

DOI

https://doi.org/10.5798/dicletip.407237

IZ

https://izlik.org/JA53BW33WA

Kaynak Göster

RIS / Bibtex

APA

Ekinci, A. (2018). Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Medical Journal, 45(1), 1-7. https://doi.org/10.5798/dicletip.407237

AMA

1.Ekinci A. Investigation of serum oxidative stress levels in patients with nasal polyps. diclemedj. 2018;45(1):1-7. doi:10.5798/dicletip.407237

Chicago

Ekinci, Adnan. 2018. “Investigation of serum oxidative stress levels in patients with nasal polyps”. Dicle Medical Journal 45 (1): 1-7. https://doi.org/10.5798/dicletip.407237.

EndNote

Ekinci A (01 Mart 2018) Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Medical Journal 45 1 1–7.

IEEE

[1]A. Ekinci, “Investigation of serum oxidative stress levels in patients with nasal polyps”, diclemedj, c. 45, sy 1, ss. 1–7, Mar. 2018, doi: 10.5798/dicletip.407237.

ISNAD

Ekinci, Adnan. “Investigation of serum oxidative stress levels in patients with nasal polyps”. Dicle Medical Journal 45/1 (01 Mart 2018): 1-7. https://doi.org/10.5798/dicletip.407237.

JAMA

1.Ekinci A. Investigation of serum oxidative stress levels in patients with nasal polyps. diclemedj. 2018;45:1–7.

MLA

Ekinci, Adnan. “Investigation of serum oxidative stress levels in patients with nasal polyps”. Dicle Medical Journal, c. 45, sy 1, Mart 2018, ss. 1-7, doi:10.5798/dicletip.407237.

Vancouver

1.Adnan Ekinci. Investigation of serum oxidative stress levels in patients with nasal polyps. diclemedj. 01 Mart 2018;45(1):1-7. doi:10.5798/dicletip.407237

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