Karanlığın Mucizesi: Melatonin ve Ovaryum Etkileşimi

Yıl 2018, , 85 - 92, 17.03.2018

Gökçe Nur Yücel Gülnur Take Kaplanoğlu Cemile Merve Seymen

https://doi.org/10.5798/dicletip.407249

Cited By: 5

Öz

Başarılı bir üreme döngüsü sağlıklı aydınlık/karanlık
döngüye sahip fizyolojik koşullarla doğrudan ilişkilidir. Sirkadyan ritim olarak
da ifade edilen, bu aydınlık karanlık döngü memeli üreme sistemleri için
önemlidir. Özellikle dişi üreme döngüsü ovulasyon ve sirkadyan ritmi içeren
kompleks bir süreçtir. Bu kompleks süreçte antioksidan aktivitesiyle melatonin
çok önemli bir yere sahip olmakla birlikte, melatonin sentezleyen organ listesi
yapılan çalışmalar ışığında gün geçtikçe artmakta ve bu organların arasında
ovaryum da yer almaktadır Dolayısı ile pineal bezin yanısıraovaryumda da
melatonin sentezlendiği ve sentezlenen melatoninin foliküler sıvıya salındığı
ileri sürülmektedir. Benzer şekilde in vitrofertilizasyon (IVF) çalışmalarında
medyuma melatoninin eklenmesi ile tedavide pozitif sonuçlar elde edilmiştir. Bu
derlemede, karanlığın mucizesi olan melatoninin genel özelliklerini ve özellikle
son yıllarda yapılan çalışmalar ile ortaya konulan ovulasyon-melatonin
ilişkisini farklı yönleri ile ele almayı amaçladık.

Anahtar Kelimeler

Melatonin, Ovaryum

Kaynakça

• 1. Reiter RJ, Tamura H, Tan DX, et al. Melatonin andthecircadiansystem:Contributionstosuccessfulfemalereproduction.FertilityandSterility. 2014;102:321-8
• 2. Coelho LA, Peres R, Amara FG, et al. Daily differentialexpression of melatonin-relatedgenesandclockgenes in ratcumulus–oocytecomplex: changesafterpinealectomy. J. PinealRes. 2015;58:490-9.
• 3. Kandemir YB, Aydin C, Gorgisen G.Theeffects of melatonin on oxidativestressandprevention of primordialfolliclelossviaactivation of mTORpathway in theratovary. Cellular andMolecularBiology .2017;63:100-6
• 4. Lerner AB, Case JD, Takahashi Y,et al.Isolation of melatonin, thepinealglandfactorthatlightensmelanocytes. J. Am. ChemSoc. 1958;80:2587.
• 5. Lerner AB, Case JD, Takahashi Y. Isolation of Melatonin and 5-Methoxyindole-3-acetic acidfrombovinepinealglands. TheJournal Of BiologicalChemistry. 1960;235.
• 6. Tamura H, Takasaki A, Taketani T, et al. Melatonin andfemalereproduction. J ObstGynecRes. 2014;40:1–11.
• 7. Cruz MH, Leal CLV, Cruz JF,et al. Essentialactions of melatonin in protectingovaryfromoxidativedamage. Theriogenology. 2014;82:925-32.
• 8. Reiter RJ, Manchester LC, Tan DX Neurotoxins: FreeRadicalMechanismsand Melatonin ProtectionCurrNeuropharmacol. 2010 Sep;8:194–210.
• 9. Reiter RJ. The melatonin rhythm: Both a clockand a calendar. Experientia. 1993;49:654–64.
• 10. Kierszenbaum AL. Histoloji ve Hücre Biyolojisi (Türkçe çeviri). Ankara: Palme Yayıncılık; 2006:565-85.
• 11. Semak I, Korik E, Antonova M, et al. Metabolism of melatonin bycytochrome P-450s in ratlivermitochondriaandmicrosomes. J PinealRes. 2008;45:515–23.
• 12. Nıkmard F, Hosseını E, Bakhtıyarı M et al. Effects of melatonin on oocytematuration in PCOS mouse model. AnimalScienceJournal (2017) 88,586–92.
• 13. He C, Ma T, Shi J et al. Melatonin anditsreceptor MT1 areinvolved in thedownstreamreactiontoluteinizinghormoneandparticipate in theregulation of luteinization in differentspecies. Journal ofPinealResearch. 2016 Oct; 61:279-90.
• 14. Tao J, Lv J, Li W et al. Exogenous melatonin reducedbloodpressure in late-termovinefetusvia MT1/MT2 receptorpathways.ReproductiveBiology 16 (2016)212–7.
• 15. Tamura H,Nakamura Y, Takiguchi S, et al. Melatonin directlysuppressessteroidproductionbypreovulatoryfollicles in thecyclichamster, J PinealRes, 25 (1998), pp. 135–41.
• 16. Agarwal A Oxidativestressanditsimplications in femaleinfertility – a clinician’sperspective. Reproductive BioMedicine;2005;11:641-50.
• 17. Tamura H, Takasaki A, Ichiro M, et al. Oxidativestressimpairsoocytequalityand melatonin protectsoocytesfromfreeradicaldamageandimprovesfertilization rate. J PinealRes. 2008;44:280–7.
• 18. Roychoudhury S, Agarwal A, Virk G, et al. Potential role of greenteacatechins in themanagement of oxidativestress-associatedinfertility. ReproductıveBıomedıcıneOnlıne 34 (2017)487–8.
• 19. Von GC, Stehle JH, Weaver DR Mammalian melatonin receptors: Molecularbiologyandsignaltransduction. Cell TissueRes. 2002;309:151–62.
• 20. Woo MMM, Tai CJ, Kang SK, et al. Direct action of melatonin in humangranulosa-lutealcells. J ClinEndocrinolMetab. 2001;86:4789–97.
• 21. Maitra SK, Chattoraj A, Mukherjee S et al. Melatonin: A potentcandidate in theregulation of fishoocytegrowthandmaturation. General andComparativeEndocrinology 181 (2013)215–22.
• 22. Sakaguchi K, Itoh MT, Takahashi N, et al. Theratoocytesynthesises melatonin. ReprodFertil Dev. 2013;25:674–82.
• 23. Danforth DR. Endocrineandparacrinecontrol of oocytedevelopment. AmericanJournal of Obstetrics&Gynecology 1995;172:747-52.
• 24. Drummond AE. The role of steroids in folliculargrowth. ReprodBiolEndocrinol. 2006;10:4-16.
• 25. Adriaens I, Jacquet P, Cortvrindt R, et al. Melatonin has dose-dependenteffects on folliculogenesis, oocytematurationcapacityandsteroidogenesis. Toxicology. 2006;228:333–43.
• 26. Poretsky L, Cataldo NA, Rosenwaks Z, et al. Theinsulin-relatedovarianregulatorysystem in healthanddisease. EndocrinolRev. 1999;20:535–82.
• 27. Chun SY, Billig H, Tilly JL, et al. Gonadotropinsuppression of apoptosis in culturedpreovulatoryfollicles: mediatory role of endogenousinsulin-likegrowthfactor I. Endocrinology. 1994;135:1845–53.
• 28. Picinato MC, Hirata AE, Cipolla-Neto J, et al. Activation of insulinand IGF-1 signalingpathwaysby melatonin through MT1 receptor in isolatedratpancreaticislets. J PinealRes. 2008;44:88–94.
• 29. Knight PG, Glister C. TGF-beta superfamilymembersandovarianfollicledevelopment. Reproduction. 2006;132:191–206.
• 30. Tatemoto H, Muto N,Sunagawa I, et al.Protection of PorcineOocytesAgainst Cell DamageCausedbyOxidativeStressDuringInVitroMaturation: Role of SuperoxideDismutase Activity in PorcineFollicularFluid.BiolReprod (2004)71:1150-7.
• 31. Ratts VS, Flaws JA, Kolp R, et al. Ablation of bcl-2 gene expressiondecreasesthenumbers of oocytesandprimordialfolliclesestablished in the post-natalfemalemousegonad. Endocrinology. 1995;136:3665–8.
• 32. Tilly JL, Tilly KI Inhibitors of oxidativestressmimictheability of follicle- stimulatinghormonetosuppressapoptosis in culturedratovarianfollicles. Endocrinology. 1995;136:242–52.
• 33. Matikainen T, Perez GI, Zheng TS, et al. Caspase-3 gene knockoutdefinescelllineagespecificityforprogrammedcelldeathsignaling in theovary. Endocrinology. 2001;142:2468–80.
• 34. Nakamura Y, Tamura H, Takayama H, et al. Increasedendogenouslevel of melatonin in preovulatoryhumanfolliclesdoes not directlyinfluenceprogesteroneproduction. Fertil Steril. 2003;80:1012–6.
• 35. Wetterberg L, Arendt J, Paunier L, et al. Human serum melatonin changesduringthemenstrualcycle. J ClinEndocrinolMetab. 1976;42:185–8.
• 36. Manca ME, Manunta LM, Spezzigu A, et al. Melatonin deprivalmodifiesfollicularandcorpuslutealgrowthdynamics in a sheepmodel. Reproduction. 2014;147:885–95.
• 37. Tamura H, Takasaki A, Taketani T, et al. The role of melatonin as an antioxidant in thefollicle. Journal of OvarianResearch. 2012;5:5.
• 38. Rodriguez-Osorio N, Kim IJ, Wang H, et al. Melatonin increasescleavage rate of porcinepreimplantationembryos in vitro. J PinealRes. 2007;43:283-8.
• 39. Piskinpasa S, Yıldız BO. Polikistik over sendromu. Hacettepe Tıp Dergisi. 2005;36:168-74.
• 40. Nayki U, Onk D, Balci G et al. Theeffect of melatonin on oxidativestressandapoptosis in experimentaldiabetesmellitus-relatedovarianinjury. GynecolEndocrinol, 2016;32:421–6.