Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Muhammed Kizilgul; Erkam Sencar; Bekir Ucan; Selvihan Beysel; Ozgur Ozcelik; Mustafa Ozbek; Erman Cakal

doi:10.5798/dicletip.410811

Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Öz

Objective: Inadequate control of glycemia in diabetic patients is the primary cause of both micro- and macrovascular complications. Several components of complete blood count were investigated and have found to be higher in diabetic patients. We aimed to evaluate white blood cell (WBC), neutrophil, lymphocyte and platelet counts and, red cell distribution width (RDW), mean platelet volume (MPV) and platelet distribution width (PDW) in type 2 diabetes mellitus (T2DM) patients with inappropriorate glycemic management (HbAlc >7%) despite using insulin therapy.

Methods: 135 type 2 diabetic patients with inappropriorate blood glucose management (HbAlc value >7 %) despite using insulin therapy for at least 3-month period (only insulin or insulin plus oral hypoglycemic agents) and 121 healthy subjects were included in the study. Demographic, anthropometric and laboratory data were recorded.

Results: WBC, neutrophil, lymphocyte and monocyte counts were higher in DM group (p<0.0001). WBC counts were positively correlated with diastolic blood pressure (DBP), body mass index (BMI), waist circumference (WC) and high-sensitive C- reactive protein (hsCRP), fasting plasma glucose (FPG), post-prandial glucose (PPG), HbA1c and triglyceride levels (p<0.05). Neutrophil counts were positively correlated with hsCRP, FPG, HbA1c, BMI, PPG, LDL-Cholesterol (LDL-C) and microalbumin levels (p<0.05). Lymphocyte counts were positively correlated with systolic blood pressure (SBP), DBP, BMI, WC and FPG, HbA1c, LDL-C and triglyceride levels (p<0.05). WBC, neutrophil and lymphocyte counts were negatively correlated with HDL-Cholesterol (HDL-C) levels (p<0.05). PDW was higher in DM group (16.65±0.59 to 16.51±0.51, p:0.043). PDW was positively correlated with age, DBP, FPG, PPG, HbA1c, LDL-C and triglyceride levels (p<0.05). Monocyte to HDL-C ratio was higher in DM group (13.50 ± 5.34 to 10.54 ± 4.29, p<0.0001).

Conclusions: In this study white blood cell, neutrophil and lymphocyte counts and PDW were higher in type 2 diabetic patients with inappropriorate glycemic management despite insulin therapy and they were correlated wıth cardio-metabolic risk factors. Leukocyte subtypes and PDW may be used as a marker for cardiovascular diseases in these patients.

Anahtar Kelimeler

Type 2 diabetes mellitus,complete blood count indices

Kaynakça

1. Guariguata L. By the numbers: New estimates from the IDF Diabetes Atlas Update for 2012. Diabetes Res Clin Pract 2012;98:524–5.
2. Koro CE, Bowlin SJ, Bourgeois N, et al. Glycemic Control From 1988 to 2000 Among U.S. Adults Diagnosed With Type 2 Diabetes. Diabetes Care 2004;27:17–20.
3. Matheus a S, Tannus LR, Cobas R a, et al. Impact of diabetes on cardiovascular disease: an update. Int J Hypertens 2013;2013:653789.
4. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868–74.
5. Madjid M, Awan I, Willerson JT, et al. Leukocyte count and coronary heart disease: Implications for risk assessment. J Am Coll Cardiol 2004;44:1945–56.
6. Barbieri J, Fontela PC, Winkelmann ER, et al. Anemia in Patients with Type 2 Diabetes Mellitus. Anemia 2015;2015:354737.
7. Gkrania-Klotsas E, Ye Z, Cooper AJ, et al. Differential white blood cell count and type 2 diabetes: Systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One 2010;5:e13405.
8. Hekimsoy Z, Payzin B, Ornek T, et al. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18:173–6.

9. Tong PC, Lee KF, So WY, et al. White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care 2004;27:216–22.
10. Wheeler JG, Mussolino ME, Gillum RF, et al. Associations between differential leucocyte count and incident coronary heart disease: 1764 Incident cases from seven prospective studies of 30 374 individuals. Eur Heart J 2004;25:1287–92.
11. Nada AM. Red cell distribution width in type 2 diabetic patients. Diabetes, Metab Syndr Obes Targets Ther 2015;8:525–33.
12. Chen X, Fang L, Lin H, Shen P, Zhang T, Li H, Li X, Yu M, Xu C, Zhang J, Lu F, DU X, Hu R ZJ. The Relationship between Type 2 Diabetes and Platelet Indicators. Iran J Public Heal 2017;46:1211–6.
13. Zhang Y, Li S, Guo Y-L, et al. Is monocyte to HDL ratio superior to monocyte count in predicting the cardiovascular outcomes: evidence from a large cohort of Chinese patients undergoing coronary angiography. Ann Med 2016;48:305–12.
14. Cetin MS, Ozcan Cetin EH, Kalender E, et al. Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome. Hear Lung Circ 2016;25:1077–86.
15. Pickup JC, Mattock MB, Chusney GD, et al. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997;40:1286–92.
16. Duncan BB, Schmidt MI, Pankow JS, et al. Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes 2003;52:1799–805.
17. Schmidt MI, Duncan BB, Sharrett a R, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999;353:1649–52.
18. Vozarova B, Weyer C, Lindsay RS, et al. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 2002;51:455–61.
19. Mulvihill NT, Foley JB. Inflammation in acute coronary syndromes. Heart 2002;87:201–4.
20. Merten M, Thiagarajan P. P-selectin expression on platelets determines size and stability of platelet aggregates. Circulation 2000;102:1931–6.
21. Rana JS, Boekholdt SM, Ridker PM, et al. Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: The EPIC-Norfolk Prospective Population Study. J Intern Med 2007;262:678–89.
22. Shah AD, Denaxas S, Nicholas O, et al. Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol 2017;69:1160–9.
23. Verdoia M, Schaffer A, Barbieri L, Aimaretti G, Marino P, Sinigaglia F, Suryapranata H DLGNASG (NAS). Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease. Diabetes Metab 2015;41:304–11.
24. Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr Clin Res Rev 2015;9:299–304.
25. Van der Loo B, Martin JF. Megakaryocytes and platelets in vascular disease. Baillieres Clin Haematol 1997;10:109–23.
26. Ferroni P, Basili S, Falco a, et al. Platelet activation in type 2 diabetes mellitus. J Thromb Haemost 2004;2:1282–91.
27. Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J 2008;49:114–6.
28. Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004;15:475–8.
29. Buch A, Kaur S, Nair R, et al. Platelet volume indices as predictive biomarkers for diabetic complications in Type 2 diabetic patients. J Lab Physicians 2017;9:84.
30. Perlstein TS, Weuve J, Pfeffer MA, et al. Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort. Arch Intern Med 2009;169:588.
31. Zalawadiya SK, Zmily H, Farah J, et al. Red cell distribution width and mortality in predominantly African-American population with decompensated heart failure. J Card Fail 2011;17:292–8.
32. Patel K V., Ferrucci L, Ershler WB, et al. Red Blood Cell Distribution Width and the Risk of Death in Middle-aged and Older Adults. Arch Intern Med 2009;169:515.
33. Hansson GK. Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis. Circ Res 2002;91:281–91.
34. Olivares R, Ducimetière P, Claude JR. Monocyte count: a risk factor for coronary heart disease? Am J Epidemiol 1993;137:49–53.
35. Gratchev A, Sobenin I, Orekhov A, et al. Monocytes as a diagnostic marker of cardiovascular diseases. Immunobiology 2012;217:476–82.
36. Barter PJ, Baker PW, Rye K-A. Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells. Curr Opin Lipidol 2002;13:285–8.
37. Murphy AJ, Woollard KJ, Hoang A, et al. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol 2008;28:2071–7.

Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Muhammed Kizilgul ^*
0000-0002-8468-9196
Türkiye

Erkam Sencar Bu kişi benim
0000-0001-5581-4886
Türkiye

Bekir Ucan Bu kişi benim
0000-0002-0810-5224
Türkiye

Selvihan Beysel Bu kişi benim
0000-0001-6963-1503
Türkiye

Ozgur Ozcelik Bu kişi benim
0000-0002-1159-5324
Türkiye

Mustafa Ozbek Bu kişi benim
0000-0003-1125-3823
Türkiye

Erman Cakal Bu kişi benim
0000-0003-4455-7276
Türkiye

Yayımlanma Tarihi

15 Haziran 2018

Gönderilme Tarihi

29 Mart 2018

Kabul Tarihi

22 Mart 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 45 Sayı: 2

DOI

https://doi.org/10.5798/dicletip.410811

IZ

https://izlik.org/JA87CW94MG

Kaynak Göster

RIS / Bibtex

APA

Kizilgul, M., Sencar, E., Ucan, B., Beysel, S., Ozcelik, O., Ozbek, M., & Cakal, E. (2018). Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control. Dicle Medical Journal, 45(2), 113-120. https://doi.org/10.5798/dicletip.410811

AMA

1.Kizilgul M, Sencar E, Ucan B, vd. Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control. diclemedj. 2018;45(2):113-120. doi:10.5798/dicletip.410811

Chicago

Kizilgul, Muhammed, Erkam Sencar, Bekir Ucan, vd. 2018. “Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control”. Dicle Medical Journal 45 (2): 113-20. https://doi.org/10.5798/dicletip.410811.

EndNote

Kizilgul M, Sencar E, Ucan B, Beysel S, Ozcelik O, Ozbek M, Cakal E (01 Haziran 2018) Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control. Dicle Medical Journal 45 2 113–120.

IEEE

[1]M. Kizilgul vd., “Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control”, diclemedj, c. 45, sy 2, ss. 113–120, Haz. 2018, doi: 10.5798/dicletip.410811.

ISNAD

Kizilgul, Muhammed - Sencar, Erkam - Ucan, Bekir - Beysel, Selvihan - Ozcelik, Ozgur - Ozbek, Mustafa - Cakal, Erman. “Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control”. Dicle Medical Journal 45/2 (01 Haziran 2018): 113-120. https://doi.org/10.5798/dicletip.410811.

JAMA

1.Kizilgul M, Sencar E, Ucan B, Beysel S, Ozcelik O, Ozbek M, Cakal E. Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control. diclemedj. 2018;45:113–120.

MLA

Kizilgul, Muhammed, vd. “Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control”. Dicle Medical Journal, c. 45, sy 2, Haziran 2018, ss. 113-20, doi:10.5798/dicletip.410811.

Vancouver

1.Muhammed Kizilgul, Erkam Sencar, Bekir Ucan, Selvihan Beysel, Ozgur Ozcelik, Mustafa Ozbek, Erman Cakal. Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control. diclemedj. 01 Haziran 2018;45(2):113-20. doi:10.5798/dicletip.410811

Cited By

Association between Inflammatory Markers and Glycemic Control in Korean Diabetic Patients

Journal of Health Informatics and Statistics

https://doi.org/10.21032/jhis.2021.46.3.247

Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh

Journal of Parasitology Research

https://doi.org/10.1155/2023/3885160

Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues

Frontiers in Cell and Developmental Biology

https://doi.org/10.3389/fcell.2021.624184

A case–control study to evaluate hematological indices in blood of diabetic and non-diabetic individuals in Ibb City, Yemen

Scientific Reports

https://doi.org/10.1038/s41598-023-43973-3

Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study

PLOS ONE

https://doi.org/10.1371/journal.pone.0272145

Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study

PLOS ONE

https://doi.org/10.1371/journal.pone.0253286

Delineating the effects of morphological changes on retinal hemodynamics in diabetic human retinas: An invitro investigation

Physics of Fluids

https://doi.org/10.1063/5.0176806

Changes in selected hematological parameters in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis

Frontiers in Medicine

https://doi.org/10.3389/fmed.2024.1294290

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Genel Tıp Dergisi

https://doi.org/10.54005/geneltip.1366271

Assessment of the differences of hematological variables and their correlation with glycemic control among type 2 diabetes mellitus patients in Iraq: Comparative cross-sectional study

International Journal of Secondary Metabolite

https://doi.org/10.21448/ijsm.1332875

Platelet indices as predictors of poor glucoregulation in type 2 diabetes mellitus adults at Bishoftu General Hospital, Ethiopia

World Journal of Diabetes

https://doi.org/10.4239/wjd.v15.i9.1889

Key biomarkers in type 2 diabetes patients: A systematic review

Diabetes, Obesity and Metabolism

https://doi.org/10.1111/dom.15991

Platelets indices clinical implications in diabetes mellitus: A broader insight

World Journal of Diabetes

https://doi.org/10.4239/wjd.v16.i4.100467

Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Association between Inflammatory Markers and Glycemic Control in Korean Diabetic Patients

Association of Chronic Toxoplasma gondii Infection with Pro-Inflamatory Cytokine Interleukin (IL)-12 Responses in Type-2 Diabetes Mellitus Patients of Bangladesh

Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues

A case–control study to evaluate hematological indices in blood of diabetic and non-diabetic individuals in Ibb City, Yemen

Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: Comparative cross-sectional study

Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study

Delineating the effects of morphological changes on retinal hemodynamics in diabetic human retinas: An invitro investigation

Changes in selected hematological parameters in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Leucocyte Value as a Signs of Microvascular Inflammation in Type 2 Diabetes Mellitus Patients

Association between hematological indices and blood glucose level among patients with type 2 diabetes

Changes in Haematological Parameters and Lipid Profiles in Diabetes Mellitus: A Literature Review

Assessment of the differences of hematological variables and their correlation with glycemic control among type 2 diabetes mellitus patients in Iraq: Comparative cross-sectional study

Platelet indices as predictors of poor glucoregulation in type 2 diabetes mellitus adults at Bishoftu General Hospital, Ethiopia

Key biomarkers in type 2 diabetes patients: A systematic review

Platelets indices clinical implications in diabetes mellitus: A broader insight