Breast Cancer Stem Cells and Iron Dependency

Ufuk Ozer

doi:10.5798/dicletip.419307

Breast Cancer Stem Cells and Iron Dependency

Öz

Objectives: Among woman, breast cancer is the most prevalent cancer worldwide. It is composed of various cell types that are classified into different subtypes such as triple negative breast cancer (TNBC), triple positive breast cancer (TPBC). TNBCs and TPBCs represent distinct genetic background, thereby leading to therapeutic diversity in breast cancer. It is critical to know their tumorigenic properties to overcome the diversity.

Methods: TPBC cell lines; BT474, HCC1954 and TNBC cell lines; MDA-MB-435, Hs578T, MDA-MB-231 were used to measure intracellular iron levels via a fluorescent probe, calcein-AM, utilizing flow cytometry. Breast cancer stem cells (BCSCs) are detected by surface expression of CD44+/CD24- markers in the lines.

Results: Here, it has shown that TNBCs have higher basal levels of iron and population of BCSCs than TPBCs. Iron addition provides enrichment of BCSCs in TPBCs.

Conclusion: Iron is an important element for maintenance of BCSCs.

Anahtar Kelimeler

Breast cancer stem cells,iron,TNBC

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Ufuk Ozer ^* Bu kişi benim
0000-0002-8362-0592
Türkiye

Yayımlanma Tarihi

15 Haziran 2018

Gönderilme Tarihi

27 Nisan 2018

Kabul Tarihi

26 Nisan 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 45 Sayı: 2

DOI

https://doi.org/10.5798/dicletip.419307

IZ

https://izlik.org/JA73MD26UZ

Kaynak Göster

RIS / Bibtex

APA

Ozer, U. (2018). Breast Cancer Stem Cells and Iron Dependency. Dicle Medical Journal, 45(2), 195-200. https://doi.org/10.5798/dicletip.419307

AMA

1.Ozer U. Breast Cancer Stem Cells and Iron Dependency. diclemedj. 2018;45(2):195-200. doi:10.5798/dicletip.419307

Chicago

Ozer, Ufuk. 2018. “Breast Cancer Stem Cells and Iron Dependency”. Dicle Medical Journal 45 (2): 195-200. https://doi.org/10.5798/dicletip.419307.

EndNote

Ozer U (01 Haziran 2018) Breast Cancer Stem Cells and Iron Dependency. Dicle Medical Journal 45 2 195–200.

IEEE

[1]U. Ozer, “Breast Cancer Stem Cells and Iron Dependency”, diclemedj, c. 45, sy 2, ss. 195–200, Haz. 2018, doi: 10.5798/dicletip.419307.

ISNAD

Ozer, Ufuk. “Breast Cancer Stem Cells and Iron Dependency”. Dicle Medical Journal 45/2 (01 Haziran 2018): 195-200. https://doi.org/10.5798/dicletip.419307.

JAMA

1.Ozer U. Breast Cancer Stem Cells and Iron Dependency. diclemedj. 2018;45:195–200.

MLA

Ozer, Ufuk. “Breast Cancer Stem Cells and Iron Dependency”. Dicle Medical Journal, c. 45, sy 2, Haziran 2018, ss. 195-00, doi:10.5798/dicletip.419307.

Vancouver

1.Ufuk Ozer. Breast Cancer Stem Cells and Iron Dependency. diclemedj. 01 Haziran 2018;45(2):195-200. doi:10.5798/dicletip.419307