Araştırma Makalesi

Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Cilt: 45 Sayı: 4 13 Aralık 2018
  • Muhammet Hulusi Satilmisoglu
  • Mehmet Gul *
  • Huseyin Altug Cakmak
  • Nilgun Isiksacan
  • Selahattin Turen
  • Ugur Kokturk
  • Emre Yilmaz
  • Muammer Karakayalı
  • Aydin Rodi Tosu
PDF İndir

Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Öz

Objective: Vitamin-D status is very important for optimal function of human body especially cardiovascular system. The aim of this study was to investigate the long term prognostic value of admission vitamin D level in acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).

Methods: One hundred fifty seven consecutive patients, who were admitted to a training and research hospital with a diagnosis of STEMI and underwent PPCI, were recruited in this prospective study. The study patients were divided into 2 groups according to their vitamin-D levels as follows: High vitamin-D group (n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease (CAD) was assessed with calculation of the SYNTAX score.

Results: There were significant negative correlations between Vitamin-D level and SYNTAX score, serum glucose, and gender, but a positive correlation with hemoglobin level. Cardiovascular mortality was found to be significantly higher in the low vitamin-D group as compared to the high group (p<0.001). In multivariate analysis, low vitamin-D level was found as a significant independent predictor of long term cardiovascular mortality after adjusting for other risk factors.

Conclusion: We demonstrated that low admission vitamin-D is related to severity of CAD. Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI.

Anahtar Kelimeler

Kaynakça

  1. 1. Lee JH, O'Keefe JH, Bell D, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?.J Am Coll Cardiol. 2008; 52: 1949-56.
  2. 2. Li YC. Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 2003; 88: 327–31.
  3. 3. Ortega A, Pérez de Prada MT, Mateos-Cáceres PJ, et al. Effect of parathyroidhormone- related protein on human platelet activation. Clinical Science. 2007; 113: 319–27.
  4. 4. Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92: 2017–29.
  5. 5. Lee JH1, Gadi R, Spertus JA, el al. Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol. 2011; 107: 1636-8.
  6. 6. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357: 266-81. Review.
  7. 7. Zittermann A, Kuhn J, Dreier J, et al. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J. 2013; 34: 1358-64.
  8. 8. Wang TJ1, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117: 503-11.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Araştırma Makalesi

Yayımlanma Tarihi

13 Aralık 2018

Gönderilme Tarihi

15 Aralık 2018

Kabul Tarihi

25 Haziran 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 45 Sayı: 4

Kaynak Göster

APA
Satilmisoglu, M. H., Gul, M., Cakmak, H. A., Isiksacan, N., Turen, S., Kokturk, U., Yilmaz, E., Karakayalı, M., & Tosu, A. R. (2018). Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention. Dicle Medical Journal, 45(4), 369-377. https://doi.org/10.5798/dicletip.497879
AMA
1.Satilmisoglu MH, Gul M, Cakmak HA, vd. Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention. diclemedj. 2018;45(4):369-377. doi:10.5798/dicletip.497879
Chicago
Satilmisoglu, Muhammet Hulusi, Mehmet Gul, Huseyin Altug Cakmak, vd. 2018. “Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention”. Dicle Medical Journal 45 (4): 369-77. https://doi.org/10.5798/dicletip.497879.
EndNote
Satilmisoglu MH, Gul M, Cakmak HA, Isiksacan N, Turen S, Kokturk U, Yilmaz E, Karakayalı M, Tosu AR (01 Aralık 2018) Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention. Dicle Medical Journal 45 4 369–377.
IEEE
[1]M. H. Satilmisoglu vd., “Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention”, diclemedj, c. 45, sy 4, ss. 369–377, Ara. 2018, doi: 10.5798/dicletip.497879.
ISNAD
Satilmisoglu, Muhammet Hulusi - Gul, Mehmet - Cakmak, Huseyin Altug - Isiksacan, Nilgun - Turen, Selahattin - Kokturk, Ugur - Yilmaz, Emre - Karakayalı, Muammer - Tosu, Aydin Rodi. “Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention”. Dicle Medical Journal 45/4 (01 Aralık 2018): 369-377. https://doi.org/10.5798/dicletip.497879.
JAMA
1.Satilmisoglu MH, Gul M, Cakmak HA, Isiksacan N, Turen S, Kokturk U, Yilmaz E, Karakayalı M, Tosu AR. Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention. diclemedj. 2018;45:369–377.
MLA
Satilmisoglu, Muhammet Hulusi, vd. “Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention”. Dicle Medical Journal, c. 45, sy 4, Aralık 2018, ss. 369-77, doi:10.5798/dicletip.497879.
Vancouver
1.Muhammet Hulusi Satilmisoglu, Mehmet Gul, Huseyin Altug Cakmak, Nilgun Isiksacan, Selahattin Turen, Ugur Kokturk, Emre Yilmaz, Muammer Karakayalı, Aydin Rodi Tosu. Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention. diclemedj. 01 Aralık 2018;45(4):369-77. doi:10.5798/dicletip.497879

Cited By