Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention
Öz
Objective:
Vitamin-D status is very important for optimal function of human body
especially cardiovascular system. The aim of this study was to investigate the
long term prognostic value of admission vitamin D level in acute ST-segment
elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary
intervention (PPCI).
Methods:
One hundred fifty seven consecutive patients, who were admitted to a training
and research hospital with a diagnosis of STEMI and underwent PPCI, were
recruited in this prospective study. The study patients were divided into 2
groups according to their vitamin-D levels as follows: High vitamin-D group
(n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease
(CAD) was assessed with calculation of the SYNTAX score.
Results:
There were significant negative correlations between Vitamin-D level and SYNTAX
score, serum glucose, and gender, but a positive correlation with hemoglobin
level. Cardiovascular mortality was found to be significantly higher in the low
vitamin-D group as compared to the high group (p<0.001). In multivariate
analysis, low vitamin-D level was found as a significant independent predictor
of long term cardiovascular mortality after adjusting for other risk factors.
Conclusion: We demonstrated that low admission vitamin-D is related to severity of CAD. Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI.
Anahtar Kelimeler
Kaynakça
- 1. Lee JH, O'Keefe JH, Bell D, et al. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?.J Am Coll Cardiol. 2008; 52: 1949-56.
- 2. Li YC. Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 2003; 88: 327–31.
- 3. Ortega A, Pérez de Prada MT, Mateos-Cáceres PJ, et al. Effect of parathyroidhormone- related protein on human platelet activation. Clinical Science. 2007; 113: 319–27.
- 4. Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92: 2017–29.
- 5. Lee JH1, Gadi R, Spertus JA, el al. Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol. 2011; 107: 1636-8.
- 6. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357: 266-81. Review.
- 7. Zittermann A, Kuhn J, Dreier J, et al. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J. 2013; 34: 1358-64.
- 8. Wang TJ1, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117: 503-11.
Ayrıntılar
Birincil Dil
Türkçe
Konular
-
Bölüm
Araştırma Makalesi
Yazarlar
Muhammet Hulusi Satilmisoglu
Bu kişi benim
0000-0001-9429-4406
Türkiye
Mehmet Gul
*
0000-0002-5721-8778
Türkiye
Huseyin Altug Cakmak
Bu kişi benim
0000-0002-5101-1928
Türkiye
Nilgun Isiksacan
Bu kişi benim
0000-0002-0230-6500
Türkiye
Selahattin Turen
Bu kişi benim
0000-0001-6752-1941
Türkiye
Ugur Kokturk
Bu kişi benim
0000-0003-0459-9295
Türkiye
Emre Yilmaz
Bu kişi benim
0000-0002-1656-3778
Türkiye
Muammer Karakayalı
Bu kişi benim
0000-0001-7385-120X
Türkiye
Aydin Rodi Tosu
Bu kişi benim
0000-0003-3545-0418
Türkiye
Yayımlanma Tarihi
13 Aralık 2018
Gönderilme Tarihi
15 Aralık 2018
Kabul Tarihi
25 Haziran 2018
Yayımlandığı Sayı
Yıl 2018 Cilt: 45 Sayı: 4
Cited By
Association between lactate/albumin ratio and prognosis in patients with acute myocardial infarction
European Journal of Clinical Investigation
https://doi.org/10.1111/eci.14094