The relation between serum vitamin D levels and clinical findings of fibromyalgia syndrome

Öz

Objective: This study was performed to identify serum 25-OH vitamin D levels and to investigate the relationship between 25-OH vitamin D and clinical findings on patients with fibromyalgia syndrome (FMS). Methods: Nineteen premenopausal women with FMS who were diagnosed according to ACR 1990 fibromyalgia diagnostic criteria and 24 premenopausal healthy women as control group were included in the study. Serum 25-OH vitamin D levels were determined in both patient and control groups. Widespread body pain, headache, fatigue, morning stiffness, sleep disorder, the number of tender points, Fibromyalgia Impact Questionnaire (FIQ) scores and Beck depression scores were evaluated as clinical findings in patients with FMS. Results: Serum 25-OH vitamin D levels were significantly lower in patients with FMS than those in control group (p=0.01). There were significantly negative correlations between 25-OH vitamin D levels and widespread body pain (r=-0.731), Beck depression scores (r=-0.777), headache (r=-0.629), and sleep disorder (r=-0.767) in the FMS group (p

Anahtar Kelimeler

• Fibromyalgia, clinical finding, 25-OH vitamin D

Serum vitamin D seviyelerinin fibromiyalji sendromunun klinik bulguları ile ilişkisi

Öz

Amaç: Bu çalışma, fibromiyalji sendromlu (FMS) hastalarda serum 25-OH vitamin D seviyelerini belirlemek ve 25-OH vitamin D seviyelerinin klinik bulgular ile ilişkisini araştırmak amacıyla yapıldı. Yöntemler: Çalışmaya ACR 1990 fibromiyalji tanı kriterlerine göre tanı konulan ondokuz premenapozal kadın ve kontrol grubu olarak 24 premenapozal sağlıklı kadın dahil edildi. Yaygın vücut ağrısı, baş ağrısı, yorgunluk, sabah tutukluğu, uyku bozukluğu, hassas nokta sayısı, fibromiyalji etki anketi skorları ve Beck depresyon skorları FMS\'nin klinik bulguları olarak değerlendirildi. Bulgular: Serum 25-OH vitamin D seviyeleri FMS\'li hastalarda kontrol grubuna göre anlamlı olarak daha düşüktü (p=0.01). FMS grubunda 25-OH vitamin D seviyeleri ile yaygın vücut ağrısı (r=-0.731), Beck depresyon skorları (r=-0.777), baş ağrısı (r=-0.629) ve uyku bozukluğu arasında (r=-0.767) anlamlı negatif korelasyonlar vardı (p

Anahtar Kelimeler

• Fibromiyalji, klinik bulgu, 25-OH vitamin D

Kaynakça

1. Gupta A, Silman AJ. Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link. Arthritis Res Ther 2004;6:98-106.
2. Marder WD, Meenan RF, et al.The present and future adequa- cy or heumatologyman power. A study of health care needs and physician supply. Arthritis Rheum 1991;34:1209-1217.
3. Abeles AM, Pillinger MH, Solitar BM, Abeles M. Narrative review: the pathophysiology of fibromyalgia. Ann Intern Med 2007;146:726-734.
4. Gur A. Etiopathogenesis in Fibromyalgia. Turk J Phys Med Rehab 2008;54:4-11.
5. Dessein PH, Shipton EA, Joffe BI, et al. Hyposecretion of adrenal androgens and the relation of serum adrenal ste- roids, serotonin and insulin-like growth factor-1 to clinical features in women with fibromyalgia. Pain 1999;83:313- 319.
6. Senel K, Baygutalp F, Baykal T, et al. Melatonin levels in premenopausal women with fibromyalgia syndrome. Rheu- matol Int 2013;33:1609-1610.
7. Karatay S, Yıldırım K, Melikoglu MA, Senel K. The rela- tionship of endocrine hormone levels and clinical param- eters in the young patients with fibromyalgia. J PM&R 2003;3:117-120.
8. Bhatty SA, Shaikh NA, Irfan M et al. Vitamin D deficiency in fibromyalgia. J Pak Med Assoc 2010;60:949-951.

9. KilicBaygutalp, Seferoglu B, Baygutalp F, Senel K. The cor- relation of serum prolactin levels and clinical parameters in the patients with fibromyalgia syndrome. J PMR Sci 2013;16:83-87.
10. Burckhardt CS, Clark SR, Bennett RM. The Fibromiyalgia Impact Questionnaire: developmentand validation. J Rheu- matol 1991;18:728-733.
11. Sarmer S, Ergin S, Yavuzer G. The validity and reliability of the Turkish version of the Fibromyalgia Impact Question- naire. Rheumatol Int 2000;20:9-12.
12. Wolfe F, Smythe HA, Yunus MB, et al. The American Col- lege of Rheumatology 1990 criteria for the classification of fibromyalgia Arthritis Rheum 1990;33:160-172.
13. Ulusoy M, Sahin N, Erkmen H. Turkish version of the Beck Anxiety Inventory. Psychometric properties. J Cognit Psy- chother1996;46:125-132.
14. Beck AT, Steer RA, Carbin MG. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evalu- ation. Clin Psychol Rev 1988;8:77-100.
15. Chapman CR, Casey KL, Dubner R, et al. Pain measure- ment: an overview. Pain 1985;22:1-31.
16. Lequesne MG, Mery C, Samson M, Gerard P. Indexes of se- verity for osteoarthritis of the hip and knee. Scand J Rheu- matol Suppl 1987;65:85-89.
17. Buysse DJ, Reynolds CF, Monk TH, et al. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric prac- tice and research. Psychiatry Res 1989:193-213.
18. Dworkin RH, Turk DC, Revicki DA, et al. Development and initial validation of an expanded and revised version of the Short-form McGill Pain Questionnaire (SF-MPQ-2) Pain 2009;144:35-42.
19. Nellen JF, Smulders YM, Jos Frissen PH, Slaats EH, Silber- busch J. Hypovitaminosis D in immigrant women: Slow to be diagnosed. BMJ 1996;312: 570-572.
20. Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vi- tamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: Identification of risk factors. Osteoporos Int 2006;17:1133- 1140.
21. Plotnikoff GA, Quigley JM. Prevalence of severe hypovita- minosis D in patients with persistent, nonspecific musculo- skeletal pain. Mayo Clin Proc 2003;78:1463-1470.
22. Badsha H, Daher M, Ooi Kong K. Myalgias or non-specific muscle pain in Arab or Indo-Pakistani patients may indicate vitamin D deficiency. Clin Rheumatol 2009;8:971-973.
23. Kose N. Blood vitamin D levels in patients with fibromyal- gia and the effectiveness of vitamin D treatment. Dicle Med J 2013;40:585-588.
24. Tandater H, Grynbaum M, Zuili I, et al. Serum 25-OH vita- min D levels in patients with fibromyalgia. Isr Med Assoc J 2009;11:339-342.
25. Abokrysha NT. Vitamin D deficiency in women with fibro- myalgia in Saudi Arabia. Pain Med 2012;13:452-458.
26. Heidari B, Shirvani JS, Firouzjahi A, et al. Association be- tween nonspecific skeletal pain and vitamin D deficiency. Int J Rheum Dis 2010;13:340-346.
27. Senel K, Baykal T. Vitamin D: Muscle Tissue and Fall. J Pediatr Sci 2012;8:143-147.
28. Shinchuk LM, Holick MF. Vitamin D and rehabilitation: Im- proving functional outcomes. Nutr Clin Pract 2007;22:297- 304.
29. Yew KS, DeMieri PJ. Disorder of bone mineral metabolism. Clin Fam Pract 2002;4:525-565.
30. Staud R. Fibromyalgia pain: do we know the source? Curr Opin Rheumatol 2004;16:157-163.
31. Atherton K, Berry DJ, Parsons T, Vitamin D and chronic widespread pain in a white middle-aged British population: Evidence from a cross-sectional population survey. Ann Rheum Dis 2009;68:817-822.
32. Armstrong DJ, Meenagh GK, Bickle I, Finch MB. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 2007;26:551-554.
33. Olama SM, Senna MK, Elarman MM, Elhawary G. Serum vitamin D level and bone mineral density in premeno- pausal Egyptian women with fibromyalgia. Rheumatol Int 2013;33:185-192.