The assessment of cardiac sempathovagal activity by heart rate variability in patients with Rheumatoid Arthritis

Öz

Objectives: It has been reported that increased sem­pathic nerve system activity due to infalammatory stress and it cause disturbance of heart rate variability (HRV) in rheumatoid arthritis (RA). In this study, it was assessed cardiac sempatovagal activity by noninvasive parameters such as HRV in patients with RA. Materials and methods: 49 patients with RA and age-matched 28 healthy subjects as control group were en­rolled to this study. Clinical and laboratory parameters of all subjects were assessed and 24-hour electrocardio­graphic Holter monitoring were performed to all of them. Results: Minimum, maximum and mean heart rate were significantly higher while mean RR interval were signifi­cantly lower in patients with RA when compared with con­trols. In addition, among time domain HRV parameters, SDNN, SDANN ve triangular index were significantly low­er in patients with RA (p

Anahtar Kelimeler

• Rheumatoid arthritis, cardiac sempatovagal activity, heart rate variability

Romatoid artritli hastalarda kardiyak sempatovagal aktivitenin kalp hızı değişkenliği ile değerlendirilmesi

Öz

Amaç: Romatoid artritte (RA) inflamatuar strese bağlı sempatik sinir sistemi aktivitesinde artış ve buna bağlı kalp hızı değişkenliğinde bozulma olduğu bildirilmiştir. Bu çalışmada RA\'lı hastalarda kalp hızı değişkenliği (KHD) gibi noninvaziv elektrofizyolojik parametreler aracılığıyla kardiyak sempatovagal aktivite değerlendirildi. Gereç ve yöntem: Bu çalışmaya 49 RA\'lı hasta ve ben­zer yaşta 28 sağlıklı birey kontrol grubu olarak alındı. Tüm bireylerin klinik ve laboratuar parametreleri değerlendirildi ve hepsine 24 saatlik Holter elektrokardiografik monitori­zasyon yapıldı. Bulgular: Hasta grubunda minimal, maksimal ve ortala­ma kalp hızları kontrol grubuna kıyasla oldukça anlamlı düzeyde yüksek ve ortalama RR intervali de anlamlı dü­zeyde düşük bulundu. Ek olarak, zaman bağımlı KHD parametreleri arasında SDNN, SDANN ve triangular in­deks anlamlı düzeyde düşük saptandı. (sırasıyla p

Anahtar Kelimeler

• Romatoid artrit, kardiyak sempatova­gal aktivite, kalp hızı değişkenliği

Kaynakça

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