Tissue necrosis following intramuscular diclofenac injection

Öz

Following intramuscular drug injections, livedoid dermatitis (also known as embolia cutis medicamentosa or Nicolau Syndrome), characterized by pain, skin discoloration, and cutaneous necrosis, may rarely be observed. In the present study, we present a 32-year-old male patient who developed Nicolau Syndrome after intramuscular injection of single-dose diclofenac sodium 75 mg due to renal colic pain. The physical examination revealed skin discoloration in his left gluteal region, and a skin necrosis. Case is very interesting because of rarely.

Anahtar Kelimeler

• diclofenac sodium; Nicolau syndrome; intramuscular injection.

Kas içi diklofenak enjeksiyonunu takiben gelisen doku nekrozu

Öz

İntramüsküler ilaç enjeksiyonları sonrasında ağrı, deride renk değişikliği ve deri nekrozu ile karakterizedir. Nadiren görülen bu sendrom, livedoid dermatitis veya embolia kutis medikamentosa (Nicolau Sendromu) adıyla anılır. Bu yazıda renal kolik ağrısı sebebi ile tek doz 75 mg. intramüsküler diklofenak sodyum enjeksiyonu yapılmış 32 yaşındaki erkek olguda gözlenen Nicolau Sendromu sunuldu. Olgunun Ş zik incelemesinde sol gluteal bölge derisinde renk değişikliği ve nekroz mevcuttu. Olgu, nadir görülmesi nedeniyle oldukça ilgi çekicidir

Anahtar Kelimeler

• Diklofenak sodyum, Nicolau sendromu, intramüsküler enjeksiyon

Kaynakça

1. Uday PK. Nicolau syndrome. In: Valia RG, ed. What is new in Dermatology, Sexually Transmitted Diseases and Lep- rosy. Bombay: 2000:22-30.
2. Muller-Vahl H, Adverse reaction after intramuscular injec- tions. Lancet 1983;1:1050.
3. Lie C, Leung F, Chow SP. Nicolau syndrome following intra- muscular diclofenac administration: a case report. J Orthop Surg 2006;14:104-7.
4. Hamilton B, Fowler P, Galloway H, Popovic N. Nicolau syndrome in an athlete following intra-muscular diclofenac injection. Acta Orthop Belg 2008;74:860-4.
5. De Sousa R, Dang A, Rataboli PV. Nicolau syndrome fol- lowing intramuscular benzathine penicilin. J Postgrad Med 2008;54:332-4.
6. Brethnach SM. Drug reactions, In: Champion RH, Burton JL, Burns DA, Brethnach S, eds. Textbook of Dermatology, 6th edn. London: Blackwell Science Ltd, 1998;3497.