Metabolik sendromlu hastalarda aortun elastik özellikleri ve aort sertliğini etkileyen faktörler [Elastic properties of the aorta and factors affecting aortic stiffness in patients with metabolic syndrome]

Öz

Objectives: In this study, we evaluated aortic stiffness and echocardiographic and laboratory factors affecting aortic stiffness in patients with metabolic syndrome (MetS). Materials and methods: Forty-six patients (25 male, mean age 47.3±6.5 years) with the diagnosis of MetS according to the Adult Treatment Panel III Final Report criteria were included. Forty-four age and gender matched healthy subjects (18 male, mean age 46.0±6.1 years) were recruited as the control group. Aortic strain, distensibility and stiffness index were calculated by M-mode echocardiography and diastolic parameters were measured. Results: Left ventricular mass index (LVMI), deceleration time (DT), isovolumic relaxation time (IVRT) were increased and mitral E/A ratio was decreased in patients with MetS compared to controls. In the MetS patients, aortic distensibility was significantly decreased (10.4±3.5 cm2.dyn-1.10-6 vs. 12.7±3.4 cm2.dyn-1.10-6, p=0.002), and ASI was significantly increased (6.5±2.0 vs. 3.2±0.8, p

Anahtar Kelimeler

• Metabolic syndrome, Echocardiography, elastic properties of aorta, hsCRP

Metabolik sendromlu hastalarda aortun elastik özellikleri ve aort sertliğini etkileyen faktörler

Öz

Amaç: Metabolik sendromda aortik sertlikte artış olması beklenmektedir. Çalışmamızda metabolik sendrom (MetS)\'lu hastalarda aortik sertlik ve bununla ilişkili ekokardiyografik ve biyokimyasal parametreleri saptamayı amaçladık. Gereç ve yöntem: Çalışmaya güncellenmiş ATP III kriterlerine göre MetS tanısı alan ardışık 46 hasta (25 erkek, ortalama yaş 47.3±6.6 yıl) ve 44 kontrol (18 erkek, ortalama yaş 46.0±6.1yıl) hastası alındı. M-mode ekokardiyografi ile aortik strain, distensibilite ve sertlik indeksi hesaplandı. Ekokardiyografik olarak diastolik parametrelerin ölçümü yapıldı. Bulgular: Ekokardiyografik parametrelerden sol ventrikül kitle indeksi, deselerasyon zamanı (DZ), izovolümetrik relaksasyon zamanı (İVRZ) MetS\'lu hastalarda kontrol grubuna kıyasla yüksek ve mitral E/A oranı ise düşük saptandı. MetS\'lu hastalarda kontrol grubuna kıyasla aortik distensibilite anlamlı düşük (10.4±3.5\'e cm2.dyn-1.10-6 karşılık 12.7±3.4 cm2.dyn-1.10-6, p=0.002), sertlik indeksi ise anlamlı yüksek saptandı (6.5±2.0\'e karşılık 3.2±0.8, p

Anahtar Kelimeler

• Metabolik sendrom, Ekokardiyografi, Aortun elastik özellikleri, C-reaktif protein

Kaynakça

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