Blood vitamin D levels in patients with fibromyalgia and the effectiveness of vitamin D treatment

Öz

Objective: The aim of this study was determination the level of vitamin D in patients diagnosed with fibromyalgia and investigation the relationship with etiopathogenesis of the disease. Methods: In this study, between the months of June and December in 2012, Metin Sabancı Bone Diseases Training and Research Hospital, Physical Therapy Outpatient Clinics, 141 patients diagnosed with fibromyalgia were included. The patients were diagnosed according to American College of Rheumatology criteria. Levels of C-reactive protein (CRP), serum calcium (Ca), phosphor (P), alkaline phosphatase (ALP), PTH, T3, T4, TSH, and vitamin D were analyzed in the blood of patients, for exclusion of a systemic illness. Deficiency of vitamin D is determined as ≤20 ng/ml and insufficiency of vitamin D is determined 21-29 ng/ml. Normal level of vitamin D is accepted as equal or ≥30 ng/ml. Results: The mean age of patients was found as 45.70±14.10 years old. Mean vitamin D level was 17.51±18.02 ng/ml. 76.6% (n=108) of all patients with fibromyalgia had vitamin D deficiency and their mean vitamin D level was detected as 12.23±10.24 ng/ml. Twenty (14.2%) of all patients had vitamin D insufficiency and their mean vitamin D level was found as 23.83±2.76 ng/ml. The lower vitamin D level was seen in patients with age less than 45 years-old and their mean vitamin D level was 14.91±10.75 ng/ml. Conclusion: Vitamin D deficiency is frequently seen in patients diagnosed with fibromyalgia and treatment with vitamin D may cause regression of the disease.

Anahtar Kelimeler

• D vitamin, fibromyalgia, calcium

Fibromiyalji hastalarında kan vitamin D düzeyleri ve D vitamini tedavisinin etkinliği

Öz

Amaç: Fibromiyalji hastalarında D vitamini düzeyini ölçmek, etyopatogenez ile olan ilişkisini belirlemek. Yöntemler: Bu çalışmaya; 2012 yılında Haziran ve Aralık ayları arasında Metin Sabancı Baltalimanı Kemik Hastalıkları Eğitim ve Araştırma Hastanesi Fizik Tedavi Polikliniğine başvuran 141 hasta alındı. Hastalarda fibromiyalji tanısı, American Collage of Rheumatology kriterlerine göre konuldu. Sistemik ve diğer romatolojik hastalıkların elimine edilebilmesi için, C-reaktif protein (CRP), eritrosit sedimentasyon hızı, serum kalsiyum (Ca), fosfor (P), alkalen fosfataz (ALP), parathormon (PTH), T3, T4, TSH düzeylerine bakıldı. Serumda D vitamini düzeyi ölçüldü. 20 ng/ml ve altındaki D vitamini değerleri, D vitamini eksikliği olarak kabul edildi. 21-29 ng/ml arasındaki değerler D vitamini yetersizliği, 30 ng/ml ve üzerindeki değerler normal kabul edildi. Bulgular: Hastaların yaş ortalaması 45.70±14.10 bulundu. Ortalama D vitamini düzeyi 17,52±18,02 ng/ml idi. Hastaların %76,6\'sında (n=108) D vitamini eksikliği olup bu hastalardaki ortalama D vitamini düzeyi 12,23±10,24 ng/ml olarak saptandı. Hastaların %14,2\'sinde (n=20) D vitamini yetersizliği mevcut olup, ortalama D vitamini düzeyi 23,83±2,76 ng/ml olarak bulundu. En düşük D vitamini düzeyi, 45 yaş altındaki hastalarımızda görüldü. Bu hastaların ortalama D vitamini düzeyi 14,91±10,75 ng/ml idi. Sonuç: Fibromiyalji hastalarında sıklıkla D vitamini eksikliği görülmektedir ve D vitamini tedavisi ile hastaların semptomlarında gerileme olmaktadır.

Anahtar Kelimeler

• D vitamini, fibromiyalji, kalsiyum

Kaynakça

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