Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis

Melahat Coban; Ustun Yilmaz; Suleyman Dolu; Emre Asilturk; Yıldızkilar Sozer; Bekir Erol; Hamit Yasar Ellidag

doi:10.5798/dicletip.706013

Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis

Öz

Objective: Peripheral vascular complications frequently seen in hemodialysis patients are associated with mortality. Fibroblast growth factor 23 (FGF23) is thought to be a phosphaturic hormone that causes mortality in hemodialysis patients. The purpose of our study was to determine the association of intact FGF23 (I-FGF23) with atherosclerotic peripheral vascular complications in patients on hemodialysis. Methods: This cross-sectional study was performed with 50 [28 (56%) male, 22 (44%) female] hemodialysis patients. Patient characteristics were compared with an age +- and sex-matched control group of 40 healthy volunteers. Atherosclerosis development was measured by carotid intima media thickness (CIMT) and arterial stiffness development was measured by brachial ankle pulse wave velocity (PWV) device. Results: Increased atherosclerosis and arterial stiffness were observed in patients with high I-FGF23 and low alpha klotho (α-KL) levels compared to healthy subjects. I-FGF23 showed an inverse and independent relationship between lipid profile. There was no relationship between I-FGF23 and atherosclerosis and arterial stiffness. Conclusion: There was no association between serum I-FGF23 and atherosclerotic peripheral vascular complications. The association between I-FGF23 and mortality may be due to cardiovascular events other than peripheral vascular complications in patients on hemodialysis.

Anahtar Kelimeler

Atherosclerosis,arterial stiffness

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Melahat Coban ^* Bu kişi benim
Türkiye

Ustun Yilmaz Bu kişi benim
Türkiye

Suleyman Dolu Bu kişi benim
Türkiye

Emre Asilturk Bu kişi benim
Türkiye

Yıldızkilar Sozer Bu kişi benim
Türkiye

Bekir Erol Bu kişi benim
Türkiye

Hamit Yasar Ellidag Bu kişi benim
Türkiye

Yayımlanma Tarihi

17 Mart 2020

Gönderilme Tarihi

22 Ekim 2019

Kabul Tarihi

7 Ocak 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 47 Sayı: 1

DOI

https://doi.org/10.5798/dicletip.706013

IZ

https://izlik.org/JA99GC66DU

Kaynak Göster

RIS / Bibtex

APA

Coban, M., Yilmaz, U., Dolu, S., Asilturk, E., Sozer, Y., Erol, B., & Ellidag, H. Y. (2020). Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis. Dicle Medical Journal, 47(1), 66-73. https://doi.org/10.5798/dicletip.706013

AMA

1.Coban M, Yilmaz U, Dolu S, vd. Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis. diclemedj. 2020;47(1):66-73. doi:10.5798/dicletip.706013

Chicago

Coban, Melahat, Ustun Yilmaz, Suleyman Dolu, vd. 2020. “Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis”. Dicle Medical Journal 47 (1): 66-73. https://doi.org/10.5798/dicletip.706013.

EndNote

Coban M, Yilmaz U, Dolu S, Asilturk E, Sozer Y, Erol B, Ellidag HY (01 Mart 2020) Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis. Dicle Medical Journal 47 1 66–73.

IEEE

[1]M. Coban vd., “Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis”, diclemedj, c. 47, sy 1, ss. 66–73, Mar. 2020, doi: 10.5798/dicletip.706013.

ISNAD

Coban, Melahat - Yilmaz, Ustun - Dolu, Suleyman - Asilturk, Emre - Sozer, Yıldızkilar - Erol, Bekir - Ellidag, Hamit Yasar. “Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis”. Dicle Medical Journal 47/1 (01 Mart 2020): 66-73. https://doi.org/10.5798/dicletip.706013.

JAMA

1.Coban M, Yilmaz U, Dolu S, Asilturk E, Sozer Y, Erol B, Ellidag HY. Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis. diclemedj. 2020;47:66–73.

MLA

Coban, Melahat, vd. “Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis”. Dicle Medical Journal, c. 47, sy 1, Mart 2020, ss. 66-73, doi:10.5798/dicletip.706013.

Vancouver

1.Melahat Coban, Ustun Yilmaz, Suleyman Dolu, Emre Asilturk, Yıldızkilar Sozer, Bekir Erol, Hamit Yasar Ellidag. Intact Fibroblast Growth Factor 23 and Peripheral Vascular Complications in Patients on Hemodialysis. diclemedj. 01 Mart 2020;47(1):66-73. doi:10.5798/dicletip.706013

Cited By

The Severity of Carotid Calcifications, but Not Fibroblast Growth Factor 23, Is Associated with Mortality in Hemodialysis: A Single Center Experience

Diseases

https://doi.org/10.3390/diseases13030073