The Relationship Between MicroRNAs And Congenital Kidney Anomalies

Kenan Yılmaz; Zubeyde Gunduz; Mehmet Serdar Kutuk; Ruhan Dusunsel; İsmail Dursun; Sibel Yel

doi:10.5798/dicletip.706048

The Relationship Between MicroRNAs And Congenital Kidney Anomalies

Öz

Objective: The purpose of this study was to identify diagnostic microRNAs (miRNAs) associated with congenital kidney anomalies. Methods: Twenty-five healthy pregnant women who were found to have fetal kidney anomaly in the second trimester of their pregnancy at Department of Perinatology, were included in the study. Serum samples were taken from the pregnant women at the moment of diagnosis in the antenatal 20th gestational week, whereas serum samples were taken from the cord blood of babies during birth. There were 11 multicystic dysplastic kidney patients, 6 autosomal recessive polycystic kidney patients, and 8 unilateral hypoplastic kidney patients. Expression of specific miRNAs was monitored using specific primer assays in Real-Time PCR. The expression of the following miRNAs was quantified: miR-17, miR-192, miR-194, miR-204, miR-215, and miR-216. Results: mir-17 expression was significantly lower in children with congenital kidney anomalies than in the control group. ROC curve analysis showed that the area under the curve was 0.700 for miR-17 in the prediction of congenital kidney anomalies. Conclusions: In children with congenital kidney anomalies, miR-17 expression was significantly different than in the control group. Thus, this miRNA may be used in the antenatal early detection of these congenital kidney anomalies.

Anahtar Kelimeler

microRNAs; kidney development; biomarker; prenatal diagnosis; children

Kaynakça

1. Vivante A, Kohl S, Hwang DY, Dworschak GC, Hildebrandt F. Single-genecauses of congenital anomalies of the kidney and urinary tract (CAKUT) in humans. PediatrNephrol. 2014; 29: 695-704.
2. Ho J, Kreidberg JA. MicroRNAs in renal development. PediatrNephrol. 2013; 28: 219-25.
3. Dias T, Sairam S, Kumarasiri S. Ultrasound diagnosis of fetal renal abnormalities. Best Pract Res ClinObstetGynaecol. 2014; 28: 403-15.
4. van de Hoek G, Nicolaou N, Giles RH, Knoers NV, Renkema KY, Bongers EM. Functional models for congenital anomalies of the kidney and urinary tract. Nephron. 2015; 129: 62-7.
5. dos Santos Junior AC, de Miranda DM, Simões e Silva AC. Congenital anomalies of the kidney and urinary tract: an embryogenetic review. Birth Defects Res C Embryo Today. 2014; 102: 374-81.
6. Caruana G, Bertram JF. Congenital anomalies of the kidney and urinary tract genetics in mice and men. Nephrology (Carlton). 2015; 20: 309-11.
7. Baldassarre A, Felli C, Prantera G, Masotti A. Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases. Genes (Basel). 2017; 8: 234.
8. Makarova JA, Shkurnikov MU, Turchinovich AA, Tonevitsky AG, Grigoriev AI. Circulating microRNAs. Biochemistry (Mosc). 2015; 80: 1117-26.

9. Ivey KN, Srivastava D. microRNAs as Developmental Regulators. Cold Spring HarbPerspect Biol. 2015; 7: a008144.
10. Van der Hauwaert C, Savary G, Hennino MF, Pottier N, Glowacki F, Cauffiez C. MicroRNAs in kidney fibrosis. NephrolTher. 2015; 11: 474-82.
11. Kito N, Endo K, Ikesue M, Weng H, Iwai N. miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury. Biomed Res Int. 2015; 2015: 465479.
12. Akkina S, Becker BN. MicroRNAs in kidney function and disease. Transl Res. 2011; 157: 236-40.
13. Badal SS, Danesh FR. MicroRNAs and their applications in kidney diseases. PediatrNephrol. 2015; 30: 727-40.
14. Trionfini P, Benigni A, Remuzzi G. MicroRNAs in kidney physiology and disease. Nat Rev Nephrol. 2015; 11: 23-33.
15. Bhatt K, Kato M, Natarajan R. Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases. Am J Physiol Renal Physiol. 2016; 310: 109-18.
16. Ho J, Pandey P, Schatton T, et al. The pro-apoptotic protein Bim is a MicroRNA target in kidney progenitors. J Am SocNephrol. 2011; 22: 1053–63.
17. Nagalakshmi VK, Ren Q, Pugh MM, Valerius MT, McMahon AP, Yu J. Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2011; 79: 317-30.
18. Zhao H, Ma SX, Shang YQ, Zhang HQ, Su W. micro RNAs in chronic kidney disease. ClinChimActa. 2019; 491: 59-65.
19. Hartung EA, Guay-Woodford LM. Autosomal recessive polycystic kidney disease: a hepatorenal fibrocystic disorder with pleiotropic effects. Pediatrics. 2014; 134: 833-45.
20. Pandey P, Brors B, Srivastava PK, et al. Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease. BMC Genomics. 2008; 9: 624.
21. Sun H, Li QW, Lv XY, et al. MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation. MolBiol Rep. 2010; 37: 2951–8.
22. Lee SO, Masyuk T, Splinter P, et al. MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest. 2008; 118: 3714–24.
23. Ho J, Pandey P, Schatton T, et al. The pro-apoptotic protein Bim is a MicroRNA target in kidney progenitors. J Am SocNephrol. 2011; 22: 1053–63.
24. Zhu S, Cao L, Zhu J, et al. Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects. ClinChimActa. 2013; 424: 66-72.
25. Song Y, Higgins H, Guo J, et al. Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children. J Transl Med. 2018; 2: 42.
26. Wojciechowska A, Braniewska A, Kozar-Kamińska K. MicroRNA in cardiovascular biology and disease. AdvClinExp Med. 2017; 26: 865-74.
27. Weber DG, Casjens S, Rozynek P, et al. Assessment of mRNA and microRNA Stabilization in Peripheral Human Blood for Multicenter Studies and Biobanks. Biomark Insights. 2010; 5: 95-102.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Kenan Yılmaz ^* Bu kişi benim
Türkiye

Zubeyde Gunduz Bu kişi benim
Türkiye

Mehmet Serdar Kutuk Bu kişi benim
Türkiye

Ruhan Dusunsel Bu kişi benim
Türkiye

İsmail Dursun Bu kişi benim
Türkiye

Sibel Yel Bu kişi benim
Türkiye

Yayımlanma Tarihi

17 Mart 2020

Gönderilme Tarihi

20 Aralık 2019

Kabul Tarihi

11 Şubat 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 47 Sayı: 1

DOI

https://doi.org/10.5798/dicletip.706048

IZ

https://izlik.org/JA75PK33GS

Kaynak Göster

RIS / Bibtex

APA

Yılmaz, K., Gunduz, Z., Kutuk, M. S., Dusunsel, R., Dursun, İ., & Yel, S. (2020). The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal, 47(1), 89-96. https://doi.org/10.5798/dicletip.706048

AMA

1.Yılmaz K, Gunduz Z, Kutuk MS, Dusunsel R, Dursun İ, Yel S. The Relationship Between MicroRNAs And Congenital Kidney Anomalies. diclemedj. 2020;47(1):89-96. doi:10.5798/dicletip.706048

Chicago

Yılmaz, Kenan, Zubeyde Gunduz, Mehmet Serdar Kutuk, Ruhan Dusunsel, İsmail Dursun, ve Sibel Yel. 2020. “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”. Dicle Medical Journal 47 (1): 89-96. https://doi.org/10.5798/dicletip.706048.

EndNote

Yılmaz K, Gunduz Z, Kutuk MS, Dusunsel R, Dursun İ, Yel S (01 Mart 2020) The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal 47 1 89–96.

IEEE

[1]K. Yılmaz, Z. Gunduz, M. S. Kutuk, R. Dusunsel, İ. Dursun, ve S. Yel, “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”, diclemedj, c. 47, sy 1, ss. 89–96, Mar. 2020, doi: 10.5798/dicletip.706048.

ISNAD

Yılmaz, Kenan - Gunduz, Zubeyde - Kutuk, Mehmet Serdar - Dusunsel, Ruhan - Dursun, İsmail - Yel, Sibel. “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”. Dicle Medical Journal 47/1 (01 Mart 2020): 89-96. https://doi.org/10.5798/dicletip.706048.

JAMA

1.Yılmaz K, Gunduz Z, Kutuk MS, Dusunsel R, Dursun İ, Yel S. The Relationship Between MicroRNAs And Congenital Kidney Anomalies. diclemedj. 2020;47:89–96.

MLA

Yılmaz, Kenan, vd. “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”. Dicle Medical Journal, c. 47, sy 1, Mart 2020, ss. 89-96, doi:10.5798/dicletip.706048.

Vancouver

1.Kenan Yılmaz, Zubeyde Gunduz, Mehmet Serdar Kutuk, Ruhan Dusunsel, İsmail Dursun, Sibel Yel. The Relationship Between MicroRNAs And Congenital Kidney Anomalies. diclemedj. 01 Mart 2020;47(1):89-96. doi:10.5798/dicletip.706048