Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Yıl 2017, Cilt: 44 Sayı: 1, 35 - 42, 17.03.2017

Zahide Yalaki , H. Mustafa Ozdemir Tugba Zengin Metin Işik

https://doi.org/10.5798/dicletip.298579

Öz

Objective: The purpose of this study was to investigate the serum levels of selenium, zinc and copper on the etiology
of idiopathic scoliosis in adolescents.
Methods: Forty four idiopathic scoliosis patients between 10 and 17 years of age were considered in this study. The
vertebra curvature degrees of the patients were between 28° and 82°. The idiopathic scoliosis patients were assigned
to two groups based on their vertebra curvature degrees. Curvature degree of 45° and lower was labeled as group 1
and curvature of upper 45° was labeled as group 2. Total blood count, serum levels of selenium, zinc and copper were
studied.
Results: Thirty three of the idiopathic scoliosis patients (75%) were female. There was no statistically significant
difference in serum zinc and copper levels between idiopathic scoliosis patients and the control group (p> 0.05).
Serum selenium levels in idiopathic scoliosis patients were lower than that of the control group and the difference
was statistically significant (p< 0.05). In terms of vertebra curvature degree and demographic characteristics of the
patients, group 2 age average was significantly higher than that of the group 1 (p< 0.05). When serum selenium, zinc,
and copper levels were compared based on the vertebra curvature degrees of the IS patients, no statistically
significant difference was observed between group 1 and 2 in laboratory measurements (p > 0.05).
Conclusion: Among the measured trace elements, selenium was lower in the serum of the IS patients. This is the first
study in Turkey that we know of about this subject and we think that further studies are needed.

Anahtar Kelimeler

idiopathic scoliosis, selenium, zinc, copper

Adolesan İdiyopatik Skolyozda Serum Selenyum, Çinko ve Bakır Düzeylerinin Araştırılması

Öz

Amaç: Bu çalışmada adolesanlardaki idiyopatik skolyozun etiyolojisinde serum selenium, çinko ve bakır düzeylerinin
araştırılması amaçlanmıştır.
Yöntemler: Çalışmaya 10-17 yaş arası idiyopatik skolyozu olan 44 hasta alınmıştır. Hastaların vertebra eğrilik
dereceleri 280 ile 820 arasında değişiklik göstermiştir. İdiopatik skolyozlu hastalar vertebra eğrilik derecelerine göre
450 altı (grup 1) ve 450 üstü (grup 2) eğrilikler olarak 2 gruba ayrılmıştır. Çocuklarda tam kan sayımı, serum
selenyum, çinko, bakır düzeyleri çalışılmıştır.
Bulgular: İdiyopatik skolyozlu hastaların 33’ü (%75) kızdır. İdiopatik skolyozlu hastalar ve kontrol grupları arasında
serum çinko ve bakır düzeylerinde istatistiksel olarak anlamlı farklılık görülmemiştir (p>0,05). İdiyopatik skolyozlu
hastalarda kontrol grubuna göre serum selenyum düzeyi düşüktür ve istatistiksel olarak anlamlı bulunmuştur
(p<0,05). Hastaların eğrilik dereceleri ve demografik özelliklerine bakıldığında, grup 2’nin yaş ortalaması, grup 1’e
göre istatistiksel anlamlı olarak daha yüksektir (p<0,05). İdiopatik skolyozlu hastaların eğrilik derecelerine göre
serum selenyum, çinko ve bakır düzeyleri karşılaştırıldığında grup 1 ile grup 2 arasında laboratuvar ölçümlerinde
istatistiksel olarak anlamlı bir fark görülmemiştir (p> 0,05).
Sonuç: Eser elementlerden olan selenyum idiopatik skolyozlu hastaların serumunda daha düşük bulunmuştur.
Çalışmamız bu konuda Türkiye’de yapılan ilk çalışmalardan biridir ve daha geniş çaplı çalışmalara ihtiyaç olduğu
düşünülmüştür.

Anahtar Kelimeler

idiyopatik skolyoz, selenyum, çinko, bakır

Kaynakça

• 1. Moreau A, Akoumé Ndong MY, Azeddine B, et al. Molecular and genetic aspects of idiopathic scoliosis. Blood test for idiopathic scoliosis. Orthopade. 2009; 38:114-6.
• 2. Grivas TB, Vasiliadis E, Savvidou OD, Triantafyllopoulos G. What a school screening program could contribute in clinical research of idiopathic scoliosis etiology. Disabil Rehabil. 2008; 30:752-62.
• 3. Ciftci T, Guneri A, Daskaya H. General anesthesia for acute appendicitis operation in a patient with kyphoscoliosis. Dicle Medical J. 2014; 41:391-3.
• 4. de Sèze M, Cugy E. Pathogenesis of idiopathic scoliosis: a review. Ann Phys Rehabil Med. 2012;55:128-38.
• 5. Ibisoglu YU, Calıs F, On A. Scoliosis prevalence in the 12-14 years old children in elementary schools in Bornova, İzmir. Türk Fiz Tıp Rehab Derg. 2012; 58:109-13.
• 6. Sud A, Tsirikos AI. Current concepts and controversies on adolescent idiopathic scoliosis: Part I. Indian J Orthop. 2013; 47:117-28.
• 7. Saikia K C, Duggal A, Bhattacharya P K, Borgohain M. Scoliosis: An epidemiological study of school children in lower Assam. Indian J Orthop. 2002; 36:243-5.
• 8. Cilli K, Tezeren G, Tas T, et al. School screening for scoliosis in Sivas, Turkey. Acta Orthop Traumatol Turc.2009; 43:426-30.
• 9. Bridwell KH. Surgical treatment of idiopathic adolescent scoliosis. Spine. 1999; 24:2607-16.
• 10. Dastych M, Cienciala J. Idiopathic scoliosis and concentrations of zinc, copper, and selenium in blood plasma. Biol Trace Elem Res. 2002; 89:105-10.
• 11. Lombardi G, Akoume MY, Colombini A, Moreau A, Banfi G. Biochemistry of adolescent idiopathic scoliosis. Adv Clin Chem. 2011; 54:165-82.
• 12. Kouwenhoven JW, Castelein RM. The pathogenesis of adolescent idiopathic scoliosis: review of the literature. Spine. 2008; 33:2898-908.
• 13. Dayer R, Haumont T, Belaieff W, Lascombes P. Idiopathic scoliosis: Etiological concepts and hypotheses. J Child Orthop. 2013; 7:11-6.
• 14. Dastych M, Cienciala J, Krbec M. Changes of selenium, copper, and zinc content in hair and serum of patients with idiopathic scoliosis. J Orthop Res. 2008; 26:1279-82.
• 15. Yang C, Niu C, Bodo M, et al. Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease. Biochem J. 1993; 289:829-35.
• 16. Ren FL, Guo X, Zhang RJ, et al. Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthritis Cartilage. 2007;15:1171-7.
• 17. Yang Z, Xie Y, Chen J, et al. High selenium may be a risk factor of adolescent idiopathic scoliosis. Med Hypotheses. 2010; 75:126-7.
• 18. Ji XR, Yang ZD, Yang XH, et al. Change of selenium in environment and risk of adolescent idiopathic scoliosis: a retrospective cohort study. Eur Rev Med Pharmacol Sci. 2013; 17:2499-503.
• 19. Oguz E, Ekinci S, Ersen O. Investigation of the radiologic evaluation and classification scheme in adolescence idiopatic scoliosis. TOTBID Dergisi. 2013; 12:73-82.
• 20. Basu TK, Donaldson D. Intestinal absorption in health and disease: micronutrients. Best Pract Res Clin Gastroenterol. 2003;17:957-79.
• 21. Ohyoshi E, Hamada Y, Nakata K, Kohata S. The interaction between human and bovine serum albumin and zinc studied by a competitive spectrophotometry. J Inorg Biochem. 1999; 75:213-8.
• 22. August D, Janghorbani M, Young VR. Determination of zinc and copper absorption at three dietary Zn-Cu ratios by using stable isotope methods in young adult and elderly subjects. Am J Clin Nutr. 1989; 50:1457-63.
• 23. Guo CH, Chen PC, Yeh MS, et al. Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis. Clin Biochem. 2011; 44:275-80.
• 24. Yang C, Wolf E, Röser K, et al. Selenium deficiency and fulvic acid supplementation induces fibrosis of cartilage and disturbs subchondral ossification in knee joints of mice: an animal model study of Kashin-Beck disease. Virchows Arch A Pathol Anat Histopathol. 1993; 423:483-91.
• 25. Lemly AD. Teratogenic effects of selenium in natural populations of freshwater fish. Ecotox Environ Safe. 1993; 26:181-204.
• 26. Dastych M, Vlach O. Zinc status in patients with idiopathic scoliosis. Spine. 1990; 15:65-6.