INH Direnç Mekanizmaları

Tanseli Gönlügür; Ugur Gönlügür

doi:10.5798/dicletip.339020

INH Direnç Mekanizmaları

Öz

Her ne kadar izoniazid (INH) ‘ın Mycobacterium tuberculosis üzerindeki etki mekanizması tam anlaşılamamış olsa da öncü ilaç olan INH sitoplazmaya pasif difüzyon ile girmektedir. KatG geni tarafından kodlanan katalaz/peroksidaz enzimi ile aktiflenmektedir. INH ‘ın aktiflenmesi ile serbest metabolik radikaller oluşmakta, bunlar da mikolik asit sentezi gibi pek çok hücresel fonksiyonu bozmaktadırlar. KatG mutasyonları INH direncinin ana sebebidir. INH 'a dirençli klinik izolatların % 50 'den fazlasında katG 315. pozisyonda serin yerine treonin 'in değiştiği bir mutasyon vardır. İnhA, ndh ve pompa genleri gibi genler de INH direncine katkıda bulunabilirler. Bu derleme yazısı Mycobacterium tuberculosis 'de INH etki mekanizmasını ve ilaç direncinin moleküler temellerini özetlemektedir.

Anahtar Kelimeler

İzoniazid,direnç,mekanizma,tüberküloz

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Derleme

Yazarlar

Tanseli Gönlügür Bu kişi benim
0000-0003-0751-6184
Türkiye

Ugur Gönlügür
0000-0001-8720-2788
Türkiye

Yayımlanma Tarihi

20 Eylül 2017

Gönderilme Tarihi

20 Eylül 2017

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2017 Cilt: 44 Sayı: 3

DOI

https://doi.org/10.5798/dicletip.339020

IZ

https://izlik.org/JA82HA22GC

Kaynak Göster

RIS / Bibtex

APA

Gönlügür, T., & Gönlügür, U. (2017). INH Direnç Mekanizmaları. Dicle Medical Journal, 44(3), 287-292. https://doi.org/10.5798/dicletip.339020

AMA

1.Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. 2017;44(3):287-292. doi:10.5798/dicletip.339020

Chicago

Gönlügür, Tanseli, ve Ugur Gönlügür. 2017. “INH Direnç Mekanizmaları”. Dicle Medical Journal 44 (3): 287-92. https://doi.org/10.5798/dicletip.339020.

EndNote

Gönlügür T, Gönlügür U (01 Eylül 2017) INH Direnç Mekanizmaları. Dicle Medical Journal 44 3 287–292.

IEEE

[1]T. Gönlügür ve U. Gönlügür, “INH Direnç Mekanizmaları”, diclemedj, c. 44, sy 3, ss. 287–292, Eyl. 2017, doi: 10.5798/dicletip.339020.

ISNAD

Gönlügür, Tanseli - Gönlügür, Ugur. “INH Direnç Mekanizmaları”. Dicle Medical Journal 44/3 (01 Eylül 2017): 287-292. https://doi.org/10.5798/dicletip.339020.

JAMA

1.Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. 2017;44:287–292.

MLA

Gönlügür, Tanseli, ve Ugur Gönlügür. “INH Direnç Mekanizmaları”. Dicle Medical Journal, c. 44, sy 3, Eylül 2017, ss. 287-92, doi:10.5798/dicletip.339020.

Vancouver

1.Tanseli Gönlügür, Ugur Gönlügür. INH Direnç Mekanizmaları. diclemedj. 01 Eylül 2017;44(3):287-92. doi:10.5798/dicletip.339020