INH Direnç Mekanizmaları

Yıl 2017, Cilt: 44 Sayı: 3, 287 - 292, 20.09.2017

Tanseli Gönlügür Ugur Gönlügür

https://doi.org/10.5798/dicletip.339020

Öz

Her ne kadar izoniazid (INH) ‘ın Mycobacterium tuberculosis üzerindeki etki mekanizması tam anlaşılamamış olsa da öncü ilaç olan INH sitoplazmaya
pasif difüzyon ile girmektedir. KatG geni tarafından kodlanan katalaz/peroksidaz
enzimi ile aktiflenmektedir.
INH
‘ın aktiflenmesi ile serbest metabolik radikaller oluşmakta, bunlar da mikolik asit
sentezi gibi pek çok hücresel fonksiyonu bozmaktadırlar.
KatG mutasyonları INH direncinin ana sebebidir. INH 'a dirençli klinik izolatların % 50 'den fazlasında katG 315. pozisyonda serin yerine treonin 'in değiştiği bir mutasyon vardır. İnhA, ndh ve pompa genleri gibi genler de INH direncine katkıda bulunabilirler. Bu derleme yazısı
Mycobacterium tuberculosis 'de INH etki mekanizmasını ve ilaç direncinin moleküler temellerini özetlemektedir.

Anahtar Kelimeler

İzoniazid, direnç, mekanizma, tüberküloz

Kaynakça

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