Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control

Yıl 2018, Cilt: 45 Sayı: 2, 113 - 120, 15.06.2018

Muhammed Kizilgul Erkam Sencar Bekir Ucan Selvihan Beysel Ozgur Ozcelik Mustafa Ozbek Erman Cakal

https://doi.org/10.5798/dicletip.410811

Cited By: 8

Öz

Objective:
Inadequate control of glycemia in diabetic patients is the primary cause of
both micro- and macrovascular complications. Several components of complete
blood count were investigated and have found to be higher in diabetic patients.
We aimed to evaluate white blood cell (WBC), neutrophil, lymphocyte and
platelet counts and, red cell distribution width (RDW), mean platelet volume
(MPV) and platelet distribution width (PDW) in type 2 diabetes mellitus (T2DM)
patients with inappropriorate glycemic management (HbAlc >7%) despite using insulin
therapy.

Methods: 135
type 2 diabetic patients with inappropriorate blood glucose management (HbAlc
value >7 %) despite using insulin therapy for at least 3-month period (only
insulin or insulin plus oral hypoglycemic agents) and 121 healthy subjects were
included in the study. Demographic, anthropometric and laboratory data were
recorded.

Results:
WBC, neutrophil, lymphocyte and monocyte counts were higher in DM group
(p<0.0001). WBC counts were positively correlated with diastolic blood
pressure (DBP), body mass index (BMI), waist circumference (WC) and
high-sensitive C- reactive protein (hsCRP), fasting plasma glucose (FPG), post-prandial
glucose (PPG), HbA1c and triglyceride levels (p<0.05). Neutrophil counts
were positively correlated with hsCRP, FPG, HbA1c, BMI, PPG, LDL-Cholesterol
(LDL-C) and microalbumin levels (p<0.05). Lymphocyte counts were positively
correlated with systolic blood pressure (SBP), DBP, BMI, WC and FPG, HbA1c,
LDL-C and triglyceride levels (p<0.05). WBC, neutrophil and lymphocyte
counts were negatively correlated with HDL-Cholesterol (HDL-C) levels
(p<0.05). PDW was higher in DM group (16.65±0.59 to 16.51±0.51, p:0.043).
PDW was positively correlated with age, DBP, FPG, PPG, HbA1c, LDL-C and
triglyceride levels (p<0.05). Monocyte to HDL-C ratio was higher in DM group
(13.50 ± 5.34 to 10.54 ± 4.29, p<0.0001).

Conclusions:
In this study white blood cell, neutrophil and lymphocyte counts and PDW were higher
in type 2 diabetic patients with inappropriorate glycemic management despite
insulin therapy and they were correlated wıth cardio-metabolic risk factors. Leukocyte
subtypes and PDW may be used as a marker for cardiovascular diseases in these
patients.

Anahtar Kelimeler

Type 2 diabetes mellitus, complete blood count indices

Kaynakça

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