Comparison of prostate biopsy pathology and radical prostatectomy pathologies

Yıl 2019, Cilt: 46 Sayı: 1, 133 - 139, 03.03.2019

Ahmet Camtosun Hasan Gökçe

https://doi.org/10.5798/dicletip.534851

Cited By: 2

Öz

Objectives:
The rate of prostate cancer has increased with the identification of the
prostate-specific antigen; however, data on biopsy pathologies determined by
transrectal ultrasonography may be incompatible with the pathology indicated in
radical prostatectomy specimens. This situation puts patients in need of
curative treatment at risk while in some patients they are overtreatment. The
aim of this study was to compare Gleason scores in radical prostatectomy
specimens with the Gleason scores determined by transrectal ultrasound-guided
biopsy pathologies.

Methods:
The data of patients who underwent radical prostatectomy in our clinic between
January 2007 and November 2018 were evaluated retrospectively. Data included
preoperative biopsy values, biopsy cores, biopsy percentage, Gleason scores
from transrectal ultrasound-guided pre-biopsy biopsy cores, Gleason scores
after radical prostatectomy, tissue cancer rates, surgical margins, and pathological
stage. The ISUP-WHO (Society of Urological Pathology: ISUP-World Health
Organization) 2014 classification was used for the pathological classification.

Results: A
total of 159 patients were evaluated. Transrectal ultrasonography-guided biopsy
pathology revealed that 82 (75.9%) patients with Gleason scores <7 had
radical prostate pathology with Gleason scores of <7. Transrectal
ultrasonography-guided biopsy pathology revealed a Gleason score of 7 in 10
(38.4%) patients. The Gleason score was > 7 in 24 (48.9%) of the patients
who had a Gleason score> 7 based on transrectal ultrasonography-guided
pathology. The radical pathology of 109 patients with biopsy pathology was ISUP
1 in 83 (76.1%) patients. The radical pathology was ISUP 3 in 5 of 16 patients
with biopsy pathology ISUP 3 (31.2%). Six patients with biopsy pathology ISUP 4
and 2 patients with ISUP 5 was reported at different stages.

Conclusions:
Differences occur between the Gleason scores reported in transrectal
ultrasonography-guided biopsy and radical prostatectomy pathologies. These
differences become more evident as age increases, as PSA level increases and as
prostate volume decreases.

Anahtar Kelimeler

Prostate cancer, biopsy

Kaynakça

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