Romatoid Artritte Nötrofil/ Lenfosit ve Platelet/ Lenfosit Oranlarının Değerlendirilmesi

Yıl 2016, Cilt: 43 Sayı: 2, 241 - 247, 01.06.2016

Elif Kılıç Aylin Rezvani Aybala Erek Toprak Hayriye Erman Sıddıka Kesgin Ayhan Emine Poyraz Nihal Özaras

Öz

Amaç: Bu çalışmanın amacı, romatoid artrit (RA), hastalık
aktivitesi ile hematolojik parametrelerden nötrofil-lenfosit
oranı (NLO), platelet lenfosit oranı (PLO) ve eritrosit dağılım
genişliği (RDW) arasındaki ilişkiyi incelemektir.
Yöntemler: Yetmiş yedi romatoid artrit hastası ve 97 sağlıklı
bireyden oluşmuş kontrol grubu bu retrospektif çalışmaya
dâhil edildi. Kontrol grubuna sistemik ve kronik herhangi
bir hastalığı olan kişiler dâhil edilmedi. Hastaların hastalık
aktivite skorları (DAS 28) ve her iki grubun hematolojik parametreleri
ve inflamasyon parametreleri istatistiksel olarak
Student-t testi ve Spearman korelasyon testiyle karşılaştırıldı.
Bulgular: Yaş ve cinsiyet açısından gruplar arasında fark
yoktu. C-reaktif protein (CRP) ve eritrosit sedimentasyon
hızı (ESH) seviyeleri RA hasta grubunda anlamlı olarak
yüksekti (p<0,001). RA hasta grubunda hemoglobin ve ortalama
platelet hacmi (MPV) düzeyleri anlamlı olarak düşük
bulunurken (sırasıyla; p<0,001, p=0,022) , trombosit,
RDW, NLO ve PLO ise anlamlı olarak yüksek bulundu (sırasıyla;
p<0.001, p<0.001, p<0,001, p<0,001). Hasta grubunda
farklı hastalık aktivitesi seviyelerinde (DAS 28) ESH
(p<0,001), mutlak nötrofil (p=0,04), trombosit (p=0,019)
seviyeleri anlamlı olarak yüksekken, lenfosit (%) (p=0.042)
seviyeleri anlamlı olarak düşüktü. PLO düzeyleri ile MPV
düzeyleri (r=-0,386) negatif anlamlı korelasyon gösterirken,
RDW seviyeleri (r=0,354) ve NLO düzeyleri (r=0,618) ile anlamlı
pozitif korelasyon göstermekteydi.
Sonuç: Romatoid artrit hastalık aktivitesinin değerlendirilmesinde
NLO ve PLO doğru sonuçlar verirken, klinik pratikte
kullanışlı bir parametre olabilirler. Geniş katılımlı çalışmalarla
bu parametreler ile hastalık şiddetinin belirlenmesinde
daha özgül endeksler geliştirilebilir.

Anahtar Kelimeler

Nötrofil lenfosit oranı (NLO), platelet lenfosit oranı (PLO), eritrosit dağılım genişliği (RDW), romatoid artrit (RA), enflamasyon

Evaluation of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Rheumatoid Arthritis

Öz

Objective: The purpose of this study is to investigate the relationship of disease activity with Neutrophil-Lympho­cyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) and red blood cell distribution width (RDW). Methods: Seventy seven RA patients and 97 healthy sub­jects were examined retrospectively. People with chronic and systemic diseases were excluded from control group of the study. The disease activity scores (DAS 28) of pa­tient group, hematologic parameters and inflammation parameters of both groups were analyzed statistically us­ing independent t-test and spearman correlation test. Results: Age and gender was not found different be­tween groups. CRP and ESR levels were significantly higher in RA group (p<0.001). Hemoglobin and platelet count were lower (p<0.001 and p=0.022), while RDW, NLR, PLR and MPV levels were significantly higher in RA group (p<0.001, p<0.001. p<0.001, p<0.001, respec­tively). In patient group, ESR (p<0.001), lymphocytes (%) (p= 0.042), absolute neutrophil (p=0.047), and platelets (p= 0.019) were positively, whereas lymphocytes were negatively affected by improvement disease activity (DAS 28) scores. PLR levels significantly negatively correlated with MPV levels (r= -0.386) but showed a significant posi­tive correlation with RDW (r= 0.354) and NLR levels (r= 0.618). Conclusion: NLR and PLR are important and promising factors for disease activity estimation of rheumatoid ar­thritis and may be used in clinical practice. In our opinion, larger studies consisting larger group will help determina­tion of disease activity of RA by more specific indices us­ing these parameters.

Anahtar Kelimeler

Neutrophil-lymphocyte ratio (NLR), Platelet Lymphocyte Ratio (PLR), Red blood cell distribution width (RDW), Rheumatoid arthritis (RA), İnflammation

Kaynakça

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