Total antioxidant and oxidant status in obese children without insulin resistance

Yıl 2014, Cilt: 41 Sayı: 2, 257 - 261, 01.06.2014

Ayşegül Doğan Demir Ufuk Erenberk İlker Tolga Özgen Emin Özkaya Aysel Vahapoğlu Türkmen Mehmet Ruşen Dündaröz Özcan Erel

https://doi.org/10.5798/diclemedj.0921.2014.02.0412

Cited By: 2

Öz

Objective: Oxidative stress in obese children may lead in adulthood serious conditions such as coronary heart diseases or type 2 diabetes mellitus. In childhood oxidative stress is associated with insulin resistance or extreme obesity. In this study, we aimed to evaluate oxidative stress status in moderately obese children without insulin resistance. Methods: A total of 38 obese children (21 male, 17 female) without insulin resistance, mean aged 9.4±3.8 years) and 51 normal weight children (25 male, 26 female) as the control group, mean aged 9.3±3.9 years) were enrolled to the study. Total oxidative status (TOS), total antioxidant capacity (TAC) were measured and oxidative stress index (OSI) was calculated. Results: The results reveal that obese children had lower TAC than normal weight children (2,27±0,28 vs. 2.76±0.35 mmol Trolox Eq./L; p

Anahtar Kelimeler

children, obesity, oxidative stress

İnsülin direnci olmayan obez çocuklarda total antioksidan ve oksidanların durumu

Öz

Amaç: Obez çocuklardaki oksidatif stres, erişkin dönemde koroner kalp hastalıkları veya tip 2 diyabet gibi ciddi durumlara öncülük edebilir. Çocukluktaki oksidatif stres insülin direnci veya ileri derece obezite ile ilişkilidir. Biz bu çalışmada, insulin direnci olmayan orta düzeyde obez çocuklarda oksidatif stres durumunu değerlendirmeyi amaçladık. Yöntemler: İnsülin direnci olmayan 38 obez çocuk (21 erkek,17 kız, ortalama yaş 9,4±3,8 yıl) ve kontrol grubu olarak 51 normal ağırlıklı çocuk (25 erkek, 26 kız, ortalama yaş 9,3±3,9 yıl) çalışmaya alındı. Total oksidatif durum (TOD), total antioksidan kapasite (TAK) ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Sonuçlar obez çocukların normal ağırlıklı çocuklardan daha düşük TAK\'a sahip olduğunu ortaya koydu (2,27±0,28 ve 2,76±0,35 mmol Trolox Eq./L; p

Anahtar Kelimeler

çocuk, obezite, oksidatif stres

Kaynakça

• Centers for Disease Control and Prevention (CDC). CDC grand rounds: childhood obesity in the United States. MMWR Morb Mortal Wkly Rep 2011;21:42-46.
• Maffeis C, Tatò L. Long-term effects of childhood obesity on morbidity and mortality. Horm Res 2001; 55:42-45.
• Pitocco D, Zaccardi F, Di Stasio E, et al. Oxidative stress, nitric oxide, and diabetes. Rev Diabet Stud 2010;7:15-25.
• Norris AL, Steinberger J, Steffen LM, Metzig AM, Schwar- zenberg SJ, Kelly AS. Circulating oxidized LDL and in- flammation in extreme pediatric obesity. Obesity (Silver Spring) 2011;19:1415-1419.
• Karamouzis I, Pervanidou P, Berardelli et al. Enhanced oxi- dative stress and platelet activation combined with reduced antioxidant capacity in obese prepubertal and adolescent girls with full or partial metabolic syndrome. Horm Metab Res 2011;43:607-613.
• Ozgen IT, Tascilar ME, Bilir P, et al . Oxidative stress in obese children and its relation with insulin resistance. J Pe- diatr Endocrinol Metab 2012;25:261-266.
• Jones DP. Redefining oxidative stress. Antioxid Redox Sig- nal 2006;8:1865-1879
• Ozcan E. A novel automated direct measurement method for total antioxidant capacity using a new generation more sta- ble ABTS radical cation. Clin Biochem 2004;37:277-285.
• Aydın M, Selçok Y, Nazlı Y, et al. Relationship between total antioxidant capacity and the severity of coronary artery dis- ease. J Clin Exp Invest 2012;3:22-28.
• Bundak R, Furman A, Gunoz H, et al. Body mass index references for Turkish children. Acta Paediatr 2006;95:194- 198.
• Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity world- wide: international survey. BMJ 2000;320:1240-1243.
• Marcus MD, Foster GD, El Ghormi L. Stability of rela- tive weight category and cardiomegalic risk factors among moderately and severe obese middle school youth. Obesity (Silver Spring) 2014;22:1118-1125.
• Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
• Valerio G, Licenziati MR, Iannuzzi A, et al. Insulin resis- tance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis 2006;16:279-284.
• Erel O. A new automated colorimetric method for measur- ing total oxidant status. Clin Biochem 2005;38:1103-1111.
• Demirbag R, Gur M, Yilmaz R, et al. Influence of oxidative stress on the development of collateral circulation in total coronary occlusions. Int J Cardiol 2007;116:14-19.
• Molnár D, Decsi T, Koletzko B. Reduced antioxidant status in obese children with multimetabolic syndrome. Int J Obes Relat Metab Disord 2004;28:1197-202.
• Miller SA, Taveras EM, Rifas-Shiman SL, et al. Association between television viewing and poor diet quality in young children. Int J Pediatr Obes 2008;3:168-176.
• Tascilar ME, Ozgen IT, Abaci A, et al. Trace elements in obese Turkish children. Biol Trace Elem Res 2011;143:188- 195.
• Puchau B, Ochoa MC, Zulet MA, et al. Dietary total anti- oxidant capacity and obesity in children and adolescents. Int J Food Sci Nutr 2010;61:713-721.
• Hassimotto NM, Pinto MD, Lajolo FM: Antioxidant status in humans after consumption of blackberry (Rubus frutico- sus L.) juices with and without defatted milk. J Agric Food Chem 2008 ;56:11727-11733.
• Potter AS, Foroudi S, Stamatikos A, et al. Drinking carrot juice increases total antioxidant status and decreases lipid peroxidation in adults. Nutr J 2011 24;10:96.
• Modun D, Music I, Vukovic J, et al. The increase in human plasma antioxidant capacity after red wine consumption is due to both plasma urate and wine polyphenols. Atheroscle- rosis 2008;197:250-256.
• Pitsavos C, Panagiotakos DB, Tzima N, et al. Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Am J Clin Nutr 2005;82:694-699.
• Lavine JE. Relative antioxidant deficiency in obese chil- dren: A weighty contributor to morbidity? J Pediatr 1999;13:132-133.
• Codoñer-Franch P, Boix-García L, Simó-Jordá R, et al. Is obesity associated with oxidative stress in children? Int J Pediatr Obes. 2010;5:56-63.
• Karamouzis I, Pervanidou P, Berardelli R, et al. Enhanced oxidative stress and platelet activation combined with re- duced antioxidant capacity in obese prepubertal and ado- lescent girls with full or partial metabolic syndrome. Horm Metab Res 2011;43:607-613.
• Oliver SR, Rosa JS, Milne GL, et al. Increased oxidative stress and altered substrate metabolism in obese children. Int J Pediatr Obes 2010;5:436-444.
• Kelly AS, Jacobs DR Jr, Sinaiko AR, et al. Relation of cir- culating oxidized LDL to obesity and insulin resistance in children. Pediatr Diabetes 2010;11:552-525.