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Comparison of Amniotic Membrane Grafts and Intraoperative Mitomycin C for Primary Pterygium Excision

Yıl 2008, Cilt: 35 Sayı: 1, 44 - 49, 01.03.2008

Öz

To evaluate and compare the effectiveness and safety of the human amniotic membrane graft with intraoperative application of Mitomycin C in primary pterygium surgery. In 60 consecutive patients, 60 eyes were included in the study. The patients were randomly divided into two groups, primary pterygium excision with intraoperative itomycin C (0.2 mg/ml) were applied to the 30 patients and amniotic membrane grafts were applied to the other 30 patients. Recurrence was detected in two patients (%6.66) who received amniotic membrane grafts, and in five patients (%16.66) who received primary pterygium excision with intraoperative Mitomycin C. No statistical difference was observed between groups according to the reccurence (p > 0.05). Suture lysis in early postoperative period was detected in one patient (%3.33) who received amniotic membrane grafts. Scleral melting was developed in one patient (%3.33) and punctate epitheliopathy was developed in one patient (%3.33) who received primary pterygium excision with intraoperative Mitomycin C. No statistical difference was observed between groups according to the complications (p > 0.05). Although no statistical difference was observed between two groups according to complication and reccurence, amniotic membrane graft method was safer than primary pterygium excision with intraoperative Mitomycin C.

Kaynakça

  • Coroneo MT, Di Girolamo N, Wakefield D. The pathogenesis of pterygia. Curr Opin Ophthalmol. 1999;10:282-288.
  • Chowers I, Pe'er J, Zamir E, Livni N, Ilsar M, Frucht-Pery J. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology. 2001;108:985-988.
  • Oldenburg JB, Garbus J, McDonnell JM, McDonnell PJ. Conjunctival pterygia. Cornea. 2000; 9: 200–204
  • Chabner BA, Ryan DP, Paz-Ares L, et al. Antineoplastic agents. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw- Hill; 2001:1431.
  • Dua HS, Azuara-Blanco A. Amniotic membrane transplantation. Br J Ophthalmol 1999;83:748-752.
  • Azuara-Blanco A, Pillai CT, Dua HS. Amniotic membrane transplantation for ocular surface reconstruction. Br J Ophthalmol 1999;83:399-402.
  • Prabhasawat P, Barton K, Burkett G. Comparison of conjonctival autogrefts, amniotic membrane grefts and primary closure for pterygium excision. Ophthalmology 1997;104:974-985.
  • Shimazaki J, Shinozaki N, Tsubota K. Transplantation of amniotic membrane and limbal autogreft for patients with recurrent pterygium associated with symblepharon. Br J Ophthalmol 1998;82:235-240.
  • Kim JC, Tseng SCG. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 1995; 14: 473–484.
  • Kang DH, See LC, Liav SB, Tsai RTF. Amniotic membrane graft for primary pterygium comparison with conjunctival autograft and topical mitomycin C treatment. Br J Ophthalmol 2000; 84:973-978.
  • King JH, Joseph AC. An atlas ophthalmic surgery.3rd ed. Philadelphia: JB Lippincott, 1981:218-229.
  • Anduze AL, Merritt JC. Pterygium: clinical classification and management in Virgin Islands. Ann Ophthalmol 1985; 17:92-95.
  • Lewallen S. A randomized trial of conjunctival autografting for pterygium in the tropics. Ophthalmology 1989;96:1612-1614.
  • Fructh-Pery J, Siganos CS, Islar M. Intraoperative application of topical mitomycin C for pterygium surgery. Ophthalmology 1996;103:674-677.
  • Mastropasqua L, Carpineto P, Ciancaglini M, Gallenga PE. Long term results of intraoperative mitomycin C in the treatment of recurrent pterygium. Br J Ophthalmol 1996;80:288-291.
  • Jaros PA, Deluise VP. Pinguecula and pterygia. Surv Ophthalmol 1988;33:41.
  • Adamis AP, Starck T, Kenyon KR. The management of pterygium. Ophthalmol Clin North Am 1990;3:611.
  • Hueber A, Grisanti S, Diestelhorst M. Photodynamic therapy for wound-healing modulation in pterygium surgery A clinical pilot study. Graefe’s Arch Clin Exp Ophthalmol.2005;243:942–946.
  • Nakamura T, Inatomi T, Sekiyama E, et all. Novel clinical application of sterilized, freeze-dried amniotic membrane to treat patients with pterygium. Acta Ophthalmol Scand. 2006;84:401-405.
  • Gulkilik G, Kocabora S, Taskapili Ozsutcu M. M, Pterygium Excision: Air-Assisted Dissection. Ophthalmologica. 2006;220:307-10.
  • Wood TO, Williams EE, Hamilton DL, Williams BL. Pterygium surgery with mitomycin and tarsorrhaphy. Trans Am Ophthalmol Soc. 2005;103:108-114.
  • Atmaca P, Bekir NA, Bülbül M. Pterjium cerrahisinde farklı tekniklerin karşılaştırılması. T Klin Oftalmoloji. 2002; 11: 212-218.
  • Hayasaka S, Noda S, Yamamoto Y, Setogawa T. Postoperative instillation of low- dose mitomycin C in the treatment of primary pterygium. Am J Ophthalmol. 1988;106:715- 718.
  • Katircioglu YA, Altiparmak UE, Duman S. Comparison of Three Methods for the Treatment of Pterygium: Amniotic Membrane Graft, Conjunctival Autograft and Conjunctival Autograft plus Mitomycin C. Orbit. 2007;26:5-13.
  • Tseng SCG, Prabhasawata P, Lee SH. Amniotic membrane trasplantation for conjunctival surface reconstruction. Am J Ophthalmol 1997; 124:765-774.
  • Tseng SCG, Dequen L, Xiang MA. Suppression of transforming growth factor beta isoforms,TGF receptor type II and myofibroblast differentiation in cultured human corneal and limbal fibroblast by amniotic membrane matrix. J Cell Physiol 1999;179:325-335.
  • Tseng SCG, Di Pascuale MA, Liu DT, Gao YY, Baradaran-Rafii A. Intraoperative mitomycin C and amniotic membrane transplantation for fornix reconstruction in severe cicatricial ocular surface diseases. Ophthalmology. 2005;112:896-903.
  • Rubinfeld RS, Pfister RR, Stein RM, et al. Serious complications of topical mitomycin-C after pterygium surgery. Ophthalmology. 1992; 99:1647-1654.

Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması

Yıl 2008, Cilt: 35 Sayı: 1, 44 - 49, 01.03.2008

Öz

Primer pterjium tedavisinde insan amnion membranı uygulanmasının etkinlik ve güvenilirliğinin, Mitomisin C uygulanması ile karşılaştırılması amaçlandı. Primer pterjium tanısı konan 60 hastanın 60 gözü çalışmaya dahil edildi. Hastalar rastgele iki gruba ayrılarak, 30 hastanın 30 gözüne, pterjium eksizyonu ile intraoperatif 0.2 mg/ml Mitomisin C uygulandı. Diğer 30 göze ise pterjium eksizyonu ve amnion membranı uygulandı. Amnion membran uygulanan grupta %6.66, Mitomisin C grubunda ise %16.66 nüks gelişti. İki grup nüks açısından karşılaştırıldığında istatiksel olarak anlamlı fark saptanmadı (p > 0.05). Komplikasyon olarak, amnion membran grubunda bir hastada (%3.33) postoperatif erken dönemde sütür açılması saptanırken, Mitomisin C grubunda bir hastada (%3.33) skleral erime, bir hastada da (%3.33) punktat epiteliyopati saptandı. Gruplar komplikasyon yönünden karşılaştırıldıklarında aralarında istatistiksel olarak anlamlı fark bulunmadı (p > 0.05). Her ne kadar iki grup arasında komplikasyon ve nüks açısından istatistiksel olarak anlamlı fark görülmese de; primer pterjium cerrahisinde amnion membran kullanımının intraoperatif Mitomisin C kullanımından daha güvenilir olduğu kanatine varıldı.

Kaynakça

  • Coroneo MT, Di Girolamo N, Wakefield D. The pathogenesis of pterygia. Curr Opin Ophthalmol. 1999;10:282-288.
  • Chowers I, Pe'er J, Zamir E, Livni N, Ilsar M, Frucht-Pery J. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology. 2001;108:985-988.
  • Oldenburg JB, Garbus J, McDonnell JM, McDonnell PJ. Conjunctival pterygia. Cornea. 2000; 9: 200–204
  • Chabner BA, Ryan DP, Paz-Ares L, et al. Antineoplastic agents. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw- Hill; 2001:1431.
  • Dua HS, Azuara-Blanco A. Amniotic membrane transplantation. Br J Ophthalmol 1999;83:748-752.
  • Azuara-Blanco A, Pillai CT, Dua HS. Amniotic membrane transplantation for ocular surface reconstruction. Br J Ophthalmol 1999;83:399-402.
  • Prabhasawat P, Barton K, Burkett G. Comparison of conjonctival autogrefts, amniotic membrane grefts and primary closure for pterygium excision. Ophthalmology 1997;104:974-985.
  • Shimazaki J, Shinozaki N, Tsubota K. Transplantation of amniotic membrane and limbal autogreft for patients with recurrent pterygium associated with symblepharon. Br J Ophthalmol 1998;82:235-240.
  • Kim JC, Tseng SCG. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 1995; 14: 473–484.
  • Kang DH, See LC, Liav SB, Tsai RTF. Amniotic membrane graft for primary pterygium comparison with conjunctival autograft and topical mitomycin C treatment. Br J Ophthalmol 2000; 84:973-978.
  • King JH, Joseph AC. An atlas ophthalmic surgery.3rd ed. Philadelphia: JB Lippincott, 1981:218-229.
  • Anduze AL, Merritt JC. Pterygium: clinical classification and management in Virgin Islands. Ann Ophthalmol 1985; 17:92-95.
  • Lewallen S. A randomized trial of conjunctival autografting for pterygium in the tropics. Ophthalmology 1989;96:1612-1614.
  • Fructh-Pery J, Siganos CS, Islar M. Intraoperative application of topical mitomycin C for pterygium surgery. Ophthalmology 1996;103:674-677.
  • Mastropasqua L, Carpineto P, Ciancaglini M, Gallenga PE. Long term results of intraoperative mitomycin C in the treatment of recurrent pterygium. Br J Ophthalmol 1996;80:288-291.
  • Jaros PA, Deluise VP. Pinguecula and pterygia. Surv Ophthalmol 1988;33:41.
  • Adamis AP, Starck T, Kenyon KR. The management of pterygium. Ophthalmol Clin North Am 1990;3:611.
  • Hueber A, Grisanti S, Diestelhorst M. Photodynamic therapy for wound-healing modulation in pterygium surgery A clinical pilot study. Graefe’s Arch Clin Exp Ophthalmol.2005;243:942–946.
  • Nakamura T, Inatomi T, Sekiyama E, et all. Novel clinical application of sterilized, freeze-dried amniotic membrane to treat patients with pterygium. Acta Ophthalmol Scand. 2006;84:401-405.
  • Gulkilik G, Kocabora S, Taskapili Ozsutcu M. M, Pterygium Excision: Air-Assisted Dissection. Ophthalmologica. 2006;220:307-10.
  • Wood TO, Williams EE, Hamilton DL, Williams BL. Pterygium surgery with mitomycin and tarsorrhaphy. Trans Am Ophthalmol Soc. 2005;103:108-114.
  • Atmaca P, Bekir NA, Bülbül M. Pterjium cerrahisinde farklı tekniklerin karşılaştırılması. T Klin Oftalmoloji. 2002; 11: 212-218.
  • Hayasaka S, Noda S, Yamamoto Y, Setogawa T. Postoperative instillation of low- dose mitomycin C in the treatment of primary pterygium. Am J Ophthalmol. 1988;106:715- 718.
  • Katircioglu YA, Altiparmak UE, Duman S. Comparison of Three Methods for the Treatment of Pterygium: Amniotic Membrane Graft, Conjunctival Autograft and Conjunctival Autograft plus Mitomycin C. Orbit. 2007;26:5-13.
  • Tseng SCG, Prabhasawata P, Lee SH. Amniotic membrane trasplantation for conjunctival surface reconstruction. Am J Ophthalmol 1997; 124:765-774.
  • Tseng SCG, Dequen L, Xiang MA. Suppression of transforming growth factor beta isoforms,TGF receptor type II and myofibroblast differentiation in cultured human corneal and limbal fibroblast by amniotic membrane matrix. J Cell Physiol 1999;179:325-335.
  • Tseng SCG, Di Pascuale MA, Liu DT, Gao YY, Baradaran-Rafii A. Intraoperative mitomycin C and amniotic membrane transplantation for fornix reconstruction in severe cicatricial ocular surface diseases. Ophthalmology. 2005;112:896-903.
  • Rubinfeld RS, Pfister RR, Stein RM, et al. Serious complications of topical mitomycin-C after pterygium surgery. Ophthalmology. 1992; 99:1647-1654.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazıları
Yazarlar

Bağdagül Bilek Bu kişi benim

Uğur Keklikçi Bu kişi benim

Yıldırım Bayazıt Şakalar Bu kişi benim

M. Kaan Ünlü Bu kişi benim

İhsan Çaça Bu kişi benim

Yayımlanma Tarihi 1 Mart 2008
Gönderilme Tarihi 2 Mart 2015
Yayımlandığı Sayı Yıl 2008 Cilt: 35 Sayı: 1

Kaynak Göster

APA Bilek, B., Keklikçi, U., Şakalar, Y. B., Ünlü, M. K., vd. (2008). Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması. Dicle Tıp Dergisi, 35(1), 44-49.
AMA Bilek B, Keklikçi U, Şakalar YB, Ünlü MK, Çaça İ. Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması. diclemedj. Mart 2008;35(1):44-49.
Chicago Bilek, Bağdagül, Uğur Keklikçi, Yıldırım Bayazıt Şakalar, M. Kaan Ünlü, ve İhsan Çaça. “Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması”. Dicle Tıp Dergisi 35, sy. 1 (Mart 2008): 44-49.
EndNote Bilek B, Keklikçi U, Şakalar YB, Ünlü MK, Çaça İ (01 Mart 2008) Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması. Dicle Tıp Dergisi 35 1 44–49.
IEEE B. Bilek, U. Keklikçi, Y. B. Şakalar, M. K. Ünlü, ve İ. Çaça, “Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması”, diclemedj, c. 35, sy. 1, ss. 44–49, 2008.
ISNAD Bilek, Bağdagül vd. “Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması”. Dicle Tıp Dergisi 35/1 (Mart 2008), 44-49.
JAMA Bilek B, Keklikçi U, Şakalar YB, Ünlü MK, Çaça İ. Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması. diclemedj. 2008;35:44–49.
MLA Bilek, Bağdagül vd. “Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması”. Dicle Tıp Dergisi, c. 35, sy. 1, 2008, ss. 44-49.
Vancouver Bilek B, Keklikçi U, Şakalar YB, Ünlü MK, Çaça İ. Primer Pterjium Eksizyonunda Amnion Membran Grefti Ve İntraoperatif Mitomisin C Yöntemlerinin Karşılaştırılması. diclemedj. 2008;35(1):44-9.