Öz
Multiple myeloma represents malignant disorder of plasma cells. Tumour extension is primarily seen within the bone and bone marrow, despite widespread distribution of plasma cells in the body. Metastatic deposits outside bone mar-row (extramedullary) are uncommon even in advanced multiple myeloma. Involvement of pulmonary parenchyma by myeloma cells either as plasmacytoma or as a pulmonary infiltrate is rare and is related to aggressive terminal phase of the disease. We are reporting a case of multiple myeloma with a pulmonary parenchymal mass as the initial pre-senting manifestation.
Anahtar Kelimeler
Pulmonary multiple myeloma extramedullary plasmacytoma (EMP).
Kaynakça
- Abdalla IA, Tabbara IA. Nonsecretory Multiple Myeloma. South Med J 2002;95(7):56-8.
- Sullivan PO, Müller NL. Pulmonary and nodal multiple my- eloma mimicking lymphoma. BJR 2006; 79: e25-e27.
- Shin MS, Carcelen MF, Ho KJ. Diverse roentgenographic manifestations of the rare pulmonary involvement in my- eloma. Chest 1992;102(8); 946-8.
- Duggal RK, Ramachandran KA. Multiple Myeloma with Extra-Medullary Dissemination in the Lung. JIACM 2002; 3(1): 93-5.
- Longo DL, Munshi NC. Plasma cell disorders. In: Fauci et al. Ed.: Harrison’s Principles of Internal Medicine:17th ed.: New York: McGraw Hill, 2008; 700-6.
- Pinto RGW Mandreker S, Verneker JA. Multiple Myeloma presenting a subcutaneous nodule on the chest wall: Di- agnosis by fine needle aspiration. Acta Cytologica 1997; 41(12): 1233-4.
- Kintzer JS, Rosenow EC, Kyle RA. Thoracic and pulmonary abnormalities in multiple myeloma:a review of 958 cases. Arch Intern Med 1978;138(6):727-30
- Grogan TM, Camp BV, Kyle RA, Muller HHK, Harris NL. Plasma cell neoplasms. In: Jaffe ES, Harris NL, Stein H, Vardiman JW. Ed. Pathology and genetics of tumours of Hemematopoietic and lymphoid tissues. Lyon:2001;142- 56.
- Galieni P, Cavo M, Pulsoni A, Avvisati G. Clinical out- come of extramedullary plasmacytoma. Haematologica 2000;85(1):47-51.
Öz
Multiple miyeloma plazma hücrelerinin malign hastalığıdır. Plazma hücreleri vücutta yaygın olarak bulunmakla birlikte, tümör genellikle kemik ve kimik iliği içine yayılır. İlerlemiş vakalarda bile ilik dışına metasazla yayılımı nadirdir. Akci-ğer parankiminin miyelom hücrelerei tarafından gerek plazmositoma olarak gerekse akciğer metastazı olarak tutulu-mu nadirdir ve hastalığın agresif terminal dönemi ile ilgilidir. Burada ilk olarak akciğer parankim kitlesi olarak belirti ve-ren bir multiple miyeloma olgusunu sunuyoruz.
Anahtar Kelimeler
Kaynakça
- Abdalla IA, Tabbara IA. Nonsecretory Multiple Myeloma. South Med J 2002;95(7):56-8.
- Sullivan PO, Müller NL. Pulmonary and nodal multiple my- eloma mimicking lymphoma. BJR 2006; 79: e25-e27.
- Shin MS, Carcelen MF, Ho KJ. Diverse roentgenographic manifestations of the rare pulmonary involvement in my- eloma. Chest 1992;102(8); 946-8.
- Duggal RK, Ramachandran KA. Multiple Myeloma with Extra-Medullary Dissemination in the Lung. JIACM 2002; 3(1): 93-5.
- Longo DL, Munshi NC. Plasma cell disorders. In: Fauci et al. Ed.: Harrison’s Principles of Internal Medicine:17th ed.: New York: McGraw Hill, 2008; 700-6.
- Pinto RGW Mandreker S, Verneker JA. Multiple Myeloma presenting a subcutaneous nodule on the chest wall: Di- agnosis by fine needle aspiration. Acta Cytologica 1997; 41(12): 1233-4.
- Kintzer JS, Rosenow EC, Kyle RA. Thoracic and pulmonary abnormalities in multiple myeloma:a review of 958 cases. Arch Intern Med 1978;138(6):727-30
- Grogan TM, Camp BV, Kyle RA, Muller HHK, Harris NL. Plasma cell neoplasms. In: Jaffe ES, Harris NL, Stein H, Vardiman JW. Ed. Pathology and genetics of tumours of Hemematopoietic and lymphoid tissues. Lyon:2001;142- 56.
- Galieni P, Cavo M, Pulsoni A, Avvisati G. Clinical out- come of extramedullary plasmacytoma. Haematologica 2000;85(1):47-51.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Olgu Sunumları |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2012 |
| Gönderilme Tarihi | 2 Mart 2015 |
| Yayımlandığı Sayı | Yıl 2012 Cilt: 39 Sayı: 1 |