Öz
Objective: Susceptibility weighted imaging (SWI) is a novel magnetic resonance technique which uses tissue magnetic susceptibility differences to generate a unique contrast, different from that of spin density, T1, T2, and T2*. The subject of this study is to display the usability and the lesion detection sensitivity of the susceptibility weighted imaging sequence at the various clinic condition in neuroradiology.Methods: Between February 2009 - May 2009 in Taksim Education and Research Hospital 180 patients, 93 (51.7%) females and 87 (48.3%) males and mean age is 51,6 , are included to this study. T2* and SWI sequences were applied to all patients additional to conventional magnetic resonance imaging (MRI) sequences by using 1,5 Tesla MRI device (Magnetom Avanto; Siemens, Erlangen, Germany). Patients were compared with conventional and T2 * sequences in terms of visibility and appearance characteristics of lesions.Results: In our study, we found out that, 12 patients have traumatic and 10 patients have non-traumatic bleeding, 17 patients have mass, 14 patients have micro bleeding spots, 18 patients have vascular malformations, 19 patients have ischemic cerebral infarct, 5 patients have cerebral mineral depositions which is related to systemic or neurodegenerative disorders, 8 patients have multiple sclerosis and 48 patients have nonspecific findings. In 30 patients no pathologic findings have been found.Conclusion: SWI sequence is a new MRI imaging sequence which is sensitive in detection of pathologies like macro-micro bleeding, mineral depositions, low-flow vascular lesions, internal architecture of the cranial masses, and also showing hemorrhagic transformations in cerebral infarcts without anatomical detail loss
Anahtar Kelimeler
Susceptibility weighted imaging neuroradiology magnetic resonance imaging
Kaynakça
- Haacke EM, Mittal S, Wu Z, et al. Susceptibility-weighted
- imaging: technical aspects and clinical applications, Part I.
- AJNR Am J Neuroradiol. 2009;30:19-30.
- Reichenbach JR, Haacke EM. High-resolution BOLD venographic imaging: a window into brain function. NMR
- Biomed 2001;14:453-467.
- Wycliffe ND, Choe J, Holshouser B, et al. Reliability in
- detection of hemorrhage in acute stroke by a new threedimensional gradient recalled echo susceptibility-weighted
- imaging technique compared to computed tomography: a
- retrospective study. J Magn Reson Imaging 2004;20:372-377.
- Nighoghossian N, Hermier M, Adeleine P, et al. Old microbleeds are a potential risk factor for cerebral bleeding after
- ischemic stroke: a gradient-echo T2*-weighted brain MRI
- study. Stroke 2002;33:735-742.
- Hermier M, Nighoghossian N, Derex L, et al. MRI of acute
- post-ischemic cerebral hemorrhage in stroke patients: diagnosis with T2*-weighted gradientecho sequences. Neuroradiology 2001;43:809-815.
- Thomas B, Somasundaram S, Thamburaj K, et al. Clinical
- applications of susceptibility weighted MR imaging of the
- brain: a pictorial review. Neuroradiology 2008;50:105-116.
- Lee BCP, Vo KD, Kido DK et al MR high resolution
- blood oxygenation level dependent venography of occult (low-flow) vascular lesions. AJNR Am J Neuroradiol 1999;20:1239-1242.
- Reichenbach JR, Jonetz-Mentzel L, Fitzek C, et al. High
- resolution blood oxygen level dependent MR venography
- (HRBV): a new technique. Neuroradiology 2001;43:364-369.
- Won Seo S, Hwa Lee B, Kim EJ, et al. Clinical significance
- of microbleeds in subcortical vascular dementia. Stroke
- ;38:1949e51.
- Haacke EM, DelProposto ZS, Chaturvedi S, et al. Imaging
- cerebral amyloid angiopathy with susceptibility-weighted
- imaging. AJNR Am J Neuroradiol 2007;28:316-17.
- Larsen JP, Britt W, Kido D, et al. Susceptibility weighted
- magnetic resonance imaging in evaluation of dementia. Radiology Case Reports 2007;2:102.
- Tong KA, Ashwal S, Holshouser BA, et al. Hemorrhagi
- shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology 2003;227:332e9.
- Tong KA, Ashwal S, Holshouser BA, et al. Diffuse axonal
- injury in children: clinical correlation with hemorrhagic lesions. Ann Neurol 2004;56:36-50.
- Babikian T, Freier MC, Tong KA, et al. Susceptibility
- weighted imaging: neuropsychologic outcome and pediatric head injury. Pediatr Neurol 2005; 33:184-194.
- Haacke EM, Mittal S, Wu Z, et al. Susceptibility-weighted
- imaging: technical aspects and clinical applications, Part 2.
- AJNR Am J Neuroradiol. 2009;30:232-252.
- Seghal V, Delproposto Z, Haacke EM et al Clinical applications of neuroimaging with susceptibility-weighted imaging. J Magn Reson Imaging 2005;22:439-450.
- Lin W, Mukherjee P, An H et al. Improving high resolution
- MR bold venographic imaging using a T1 reducing contrast
- agent. J Magn Reson Imaging 1999;10:118-123.
- Oot RF, New PF, Pile-Spellman J, et al. The detection of
- intracranial calcifications by MR. AJNR Am J Neuroradiol
- ;7:801-809.
- Avrahami E, Cohn DF, Feibel M, et al. MRI demonstration
- and CT correlation of the brain in patients with idiopathic
- intracerebral calcification. J Neurol 1994;241:381-384.
- Tsuchiya K, Makita K, Furui S, et al. MRI appearances of
- calcified regions within intracranial tumors. Neuroradiology 1993;35:341-344.
- Wu Z, Mittal S, Kish K, et al. Identification of calcification with magnetic resonance imaging using susceptibilityweighted imaging: a case study. J Magn Reson Imaging 2009;29:177-182.
- Harder SL, Hopp KM, Ward H, et al. Mineralization of the
- deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging. AJNR Am J Neuroradiol
- ;29:176-183.
- Qian ZM, Shen X. Brain iron transport and neurodegeneration. Trends Mol Med 2001;7:103-108.
Öz
Amaç: Klinik uygulamaya yakın zamanda giren Susceptibility Weighted Imaging (SWI) sekansı dokuların manyetik yatkınlık farklarını kullanarak kontrast oluşturan, T1, T2, T2* ve proton dansitesinden farklı yeni bir sekanstır. Çalışmamızda, nöroradyolojide susceptibility weighted imaging sekansının kullanılabilirliği ve lezyon saptamadaki duyarlılığının ortaya konması amaçlandı.
Yöntemler: Şubat 2009- Mayıs 2009 tarihleri arasında S.B. Taksim Eğitim ve Araştırma Hastanesinde klinisyen tarafından magnetik rezonans (MR) istemi yapılmış ortalama 51,6 yaşında (Aralık: 5-86) ,93’ü (%51,7) kadın ve 87’si (%48,3) erkek 180 hasta çalışmaya dahil edildi. Tüm hastalara 1,5-T MR cihazı (Magnetom Avanto; Siemens, Erlangen, Almanya) kullanılarak konvansiyonel sekanslara ek olarak aksiyal T2* ve SWI sekansları ile görüntüler alındı. Hastalar lezyon görülebilirliği ve görünüm özellikleri açısından konvansiyonel ve T2* sekans ile karşılaştırıldı.
Bulgular: Çalışmamızda 12 hastada travmatik, 10 hastada notravmatik kanama, 17 hastada kitle, 14 hastada mikrokanama odakları, 18 hastada vasküler malformasyon, 19 hastada iskemik serebral enfarkt, 5 hastada sistemik veya nörodejeneratif hastalığa bağlı serebral minereal birikimi, 8 hastada multiple skleroz ve 48 hastada nonpesifik bulgular saptanmıştır. Toplam 30 hastada ise herhangi bir patolojik bulgu saptanmamıştır.
Sonuç: SWI sekansı, anatomik detay kaybı olmaksızın yavaş akımlı vasküler lezyonlar, mikro-makro kanamalar, mineral birikimini saptamada, kranial kitlelerin iç yapısını anlamada ve serebral enfarktlarda hemorajik transformasyonu saptamada duyarlı yeni bir MR sekansıdır.
Anahtar kelimeler: Susceptibility weighted imaging, nöroradyoloji, manyetik rezonans görüntüleme
Anahtar Kelimeler
Susceptibility weighted imaging nöroradyoloji manyetik rezonans görüntüleme
Kaynakça
- Haacke EM, Mittal S, Wu Z, et al. Susceptibility-weighted
- imaging: technical aspects and clinical applications, Part I.
- AJNR Am J Neuroradiol. 2009;30:19-30.
- Reichenbach JR, Haacke EM. High-resolution BOLD venographic imaging: a window into brain function. NMR
- Biomed 2001;14:453-467.
- Wycliffe ND, Choe J, Holshouser B, et al. Reliability in
- detection of hemorrhage in acute stroke by a new threedimensional gradient recalled echo susceptibility-weighted
- imaging technique compared to computed tomography: a
- retrospective study. J Magn Reson Imaging 2004;20:372-377.
- Nighoghossian N, Hermier M, Adeleine P, et al. Old microbleeds are a potential risk factor for cerebral bleeding after
- ischemic stroke: a gradient-echo T2*-weighted brain MRI
- study. Stroke 2002;33:735-742.
- Hermier M, Nighoghossian N, Derex L, et al. MRI of acute
- post-ischemic cerebral hemorrhage in stroke patients: diagnosis with T2*-weighted gradientecho sequences. Neuroradiology 2001;43:809-815.
- Thomas B, Somasundaram S, Thamburaj K, et al. Clinical
- applications of susceptibility weighted MR imaging of the
- brain: a pictorial review. Neuroradiology 2008;50:105-116.
- Lee BCP, Vo KD, Kido DK et al MR high resolution
- blood oxygenation level dependent venography of occult (low-flow) vascular lesions. AJNR Am J Neuroradiol 1999;20:1239-1242.
- Reichenbach JR, Jonetz-Mentzel L, Fitzek C, et al. High
- resolution blood oxygen level dependent MR venography
- (HRBV): a new technique. Neuroradiology 2001;43:364-369.
- Won Seo S, Hwa Lee B, Kim EJ, et al. Clinical significance
- of microbleeds in subcortical vascular dementia. Stroke
- ;38:1949e51.
- Haacke EM, DelProposto ZS, Chaturvedi S, et al. Imaging
- cerebral amyloid angiopathy with susceptibility-weighted
- imaging. AJNR Am J Neuroradiol 2007;28:316-17.
- Larsen JP, Britt W, Kido D, et al. Susceptibility weighted
- magnetic resonance imaging in evaluation of dementia. Radiology Case Reports 2007;2:102.
- Tong KA, Ashwal S, Holshouser BA, et al. Hemorrhagi
- shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology 2003;227:332e9.
- Tong KA, Ashwal S, Holshouser BA, et al. Diffuse axonal
- injury in children: clinical correlation with hemorrhagic lesions. Ann Neurol 2004;56:36-50.
- Babikian T, Freier MC, Tong KA, et al. Susceptibility
- weighted imaging: neuropsychologic outcome and pediatric head injury. Pediatr Neurol 2005; 33:184-194.
- Haacke EM, Mittal S, Wu Z, et al. Susceptibility-weighted
- imaging: technical aspects and clinical applications, Part 2.
- AJNR Am J Neuroradiol. 2009;30:232-252.
- Seghal V, Delproposto Z, Haacke EM et al Clinical applications of neuroimaging with susceptibility-weighted imaging. J Magn Reson Imaging 2005;22:439-450.
- Lin W, Mukherjee P, An H et al. Improving high resolution
- MR bold venographic imaging using a T1 reducing contrast
- agent. J Magn Reson Imaging 1999;10:118-123.
- Oot RF, New PF, Pile-Spellman J, et al. The detection of
- intracranial calcifications by MR. AJNR Am J Neuroradiol
- ;7:801-809.
- Avrahami E, Cohn DF, Feibel M, et al. MRI demonstration
- and CT correlation of the brain in patients with idiopathic
- intracerebral calcification. J Neurol 1994;241:381-384.
- Tsuchiya K, Makita K, Furui S, et al. MRI appearances of
- calcified regions within intracranial tumors. Neuroradiology 1993;35:341-344.
- Wu Z, Mittal S, Kish K, et al. Identification of calcification with magnetic resonance imaging using susceptibilityweighted imaging: a case study. J Magn Reson Imaging 2009;29:177-182.
- Harder SL, Hopp KM, Ward H, et al. Mineralization of the
- deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging. AJNR Am J Neuroradiol
- ;29:176-183.
- Qian ZM, Shen X. Brain iron transport and neurodegeneration. Trends Mol Med 2001;7:103-108.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 8 Temmuz 2015 |
| Gönderilme Tarihi | 8 Temmuz 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 42 Sayı: 2 |