The Relationship Between IgA Vasculitis and Antioxidant Activity In Children

Yıl 2021, Cilt: 48 Sayı: 2, 212 - 219, 01.06.2021

Hayrettin Temel

https://doi.org/10.5798/dicletip.944308

Öz

Objective: Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis seen in children. The aim of this study is to investigate the relationship between malondialdehyde-induced oxidative stress, antioxidant system and organ involvement in IgAV patients.
Method: 32 patients and 28 healthy children were included in the study. Serum malondialdehyde, reduced glutathione, vitamin E, vitamin C, retinol, and beta-carotene levels were measured in patients (separately in both the active and remission phases) and healthy children.
Results: MDA levels were significantly higher in patients with active phase while reduced glutathione and vitamin C levels were markedly lower in both the active and the remission phases. Retinol and beta-carotene levels were lower in the active phase. It was found that retinol levels were significantly lower in patients with gastrointestinal system involvement compared to those without. Vitamin C levels were significantly lower in those with kidney involvement compared to those without. Also, a negative correlation was observed between retinol levels and the number of organs involved.
Conclusion: We consider that especially vitamin C and vitamin A may be used in the treatment of IgAV. However, whether the derangements of the oxidant/antioxidant balance in the direction of increased oxidative stress are consequences or causes of the events occurring in the active phase of IgAV are open to further investigation.

Anahtar Kelimeler

IgA vasculitis, malondialdehyde, vitamin E, vitamin C, vitamin A, IgA vasculitis, malondialdehyde, vitamin E, vitamin C, vitamin A

Kaynakça

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