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Effects of Rhodiola rosea on indomethacin-induced gastric injury

Yıl 2021, Cilt: 48 Sayı: 4, 732 - 739, 01.12.2021
https://doi.org/10.5798/dicletip.1037590

Öz

Kaynakça

  • 1.Tytgat GN. Etiopathogenetic principles and pepticulcer disease classification. Dig Dis. 2011; 29: 454-8.
  • 2.Xiao X, Nakatsu G, Jin Y, et al. Gut MicrobiotaMediates Protection Against Enteropathy Induced byIndomethacin. Sci Rep. 2017; 7: 40317.
  • 3.McRorie JW, Kirby JA, Miner PB. Histamine2-receptor antagonists: Rapid development oftachyphylaxis with repeat dosing. World J GastrointestPharmacol Ther. 2014; 5: 57-62.

Effects of Rhodiola rosea on indomethacin-induced gastric injury

Yıl 2021, Cilt: 48 Sayı: 4, 732 - 739, 01.12.2021
https://doi.org/10.5798/dicletip.1037590

Öz

Objective: The objective of the present study was to evaluate the effects of Rhodiola rosea in the indomethacin-induced ulcer model in rats and to clarify the underlying mechanisms of action.
Methods: Rats in treatment groups were treated with Rhodiola rosea (RR) 14 days. Peptic ulcer was induced by indomethacin (IND) injection (100 mg/kg, p.o.). The groups (n = 6) were designed as; Group I (control); Group II (IND): After 24h of food starvation, rats were given only 100 mg/kg IND by oral gavage to induce gastric mucosal injury. Group III (ESO): Rats were pretreated with 20 mg/kg of ESO for 14 consecutive days by oral gavage. Group IV (RR): Rats were pretreated with 500 mg/kg RR for 14 consecutive days with oral gavage.
Results: Rhodiola rosea effectively alleviated indomethacin-induced ulcer via reduction in oxidative stress (decreased MDA and increased SOD, and GSH). Moreover, Rhodiola rosea alleviated indomethacin-induced damage by regulating expressions of COX enzymes, prostaglandin E2, proliferating cell nuclear antigen (PCNA), cell proliferation, apoptosis and regulated the NF-κB signaling pathway. Rhodiola rosea also attenuated inflammatory injury by suppressing TNF-𝛼𝛼, IL-1β, and NF-κB. The caspase-3 expression was also down-regulated in stomach tissues.
Conclusions: In conclusion, Rhodiola rosea protected the gastric mucosa from harmful effects of indomethacin and as a natural medicinal herb, Rhodiola rosea might be a potential therapeutic agent for preventing and treating indomethacin-induced gastric damage.

Kaynakça

  • 1.Tytgat GN. Etiopathogenetic principles and pepticulcer disease classification. Dig Dis. 2011; 29: 454-8.
  • 2.Xiao X, Nakatsu G, Jin Y, et al. Gut MicrobiotaMediates Protection Against Enteropathy Induced byIndomethacin. Sci Rep. 2017; 7: 40317.
  • 3.McRorie JW, Kirby JA, Miner PB. Histamine2-receptor antagonists: Rapid development oftachyphylaxis with repeat dosing. World J GastrointestPharmacol Ther. 2014; 5: 57-62.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Articles
Yazarlar

Irmak Ferah OKKAY Bu kişi benim

Ufuk OKKAY Bu kişi benim

Ozhan KARATAS Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2021
Gönderilme Tarihi 10 Temmuz 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 48 Sayı: 4

Kaynak Göster

APA OKKAY, I. F., OKKAY, U., & KARATAS, O. (2021). Effects of Rhodiola rosea on indomethacin-induced gastric injury. Dicle Tıp Dergisi, 48(4), 732-739. https://doi.org/10.5798/dicletip.1037590
AMA OKKAY IF, OKKAY U, KARATAS O. Effects of Rhodiola rosea on indomethacin-induced gastric injury. diclemedj. Aralık 2021;48(4):732-739. doi:10.5798/dicletip.1037590
Chicago OKKAY, Irmak Ferah, Ufuk OKKAY, ve Ozhan KARATAS. “Effects of Rhodiola Rosea on Indomethacin-Induced Gastric Injury”. Dicle Tıp Dergisi 48, sy. 4 (Aralık 2021): 732-39. https://doi.org/10.5798/dicletip.1037590.
EndNote OKKAY IF, OKKAY U, KARATAS O (01 Aralık 2021) Effects of Rhodiola rosea on indomethacin-induced gastric injury. Dicle Tıp Dergisi 48 4 732–739.
IEEE I. F. OKKAY, U. OKKAY, ve O. KARATAS, “Effects of Rhodiola rosea on indomethacin-induced gastric injury”, diclemedj, c. 48, sy. 4, ss. 732–739, 2021, doi: 10.5798/dicletip.1037590.
ISNAD OKKAY, Irmak Ferah vd. “Effects of Rhodiola Rosea on Indomethacin-Induced Gastric Injury”. Dicle Tıp Dergisi 48/4 (Aralık 2021), 732-739. https://doi.org/10.5798/dicletip.1037590.
JAMA OKKAY IF, OKKAY U, KARATAS O. Effects of Rhodiola rosea on indomethacin-induced gastric injury. diclemedj. 2021;48:732–739.
MLA OKKAY, Irmak Ferah vd. “Effects of Rhodiola Rosea on Indomethacin-Induced Gastric Injury”. Dicle Tıp Dergisi, c. 48, sy. 4, 2021, ss. 732-9, doi:10.5798/dicletip.1037590.
Vancouver OKKAY IF, OKKAY U, KARATAS O. Effects of Rhodiola rosea on indomethacin-induced gastric injury. diclemedj. 2021;48(4):732-9.