Prognostic Significance of Monocyte to High-density Lipoprotein Ratio in Patients With Chronic Coronary Artery Occlusion

Yıl 2022, Cilt: 49 Sayı: 1, 12 - 20, 11.03.2022

Muhammed Demir Mehmet Özbek Adem Aktan Tuncay Güzel Burhan Aslan Hakkı Şimşek

https://doi.org/10.5798/dicletip.1085926

Öz

Prognostic Significance of Monocyte to High-density Lipoprotein Ratio in Patients With Chronic Coronary Artery Occlusion

Öz

Objective: Monocyte to high-density lipoprotein ratio (MHR) is a biomarker of inflammatory response. In this study, we investigated the relationship between MHR and mortality in patients with chronic coronary artery occlusion (CTO).
Method: Retrospective observational study including 493 patients over a follow up period of 73 months. Blood samples were taken before cardiac catheterization for coronary angiography.
Results: Median follow-up was 48 months(26-73) . Patients were seperated into two groups: (I) MHR <17.68 (n=278, 95 females) and (II) MHR ≥17.68 (n=215, 45 females). Mortality was considerably higher in MHR II than in MHR I (n=70 vs. n=43; p<0,001). MHR was an independent predictor of mortality (OR: 1.089, 95% [CI]: 1.055-1.124, p<0,001). Lower survival rates were found in MHR II on Kaplan-Meier analyses when compared to that of MHR I (75.223±2.670 vs. 89.220±2.102, p<0,001).
Conclusions: As a simple, easy applicable and universal marker, MHR may be a parameter that predicts mortality risk and survival time in CTO patients.

Anahtar Kelimeler

Prognosis, inflammation, mortality, atherosclerosis, Prognosis, inflammation, mortality, atherosclerosis

Kaynakça

• 1.Fefer P, Knudtson ML, Cheema AN, et all. Currentperspectives on coronary chronic total occlusions:the Canadian Multicenter Chronic Total OcclusionsRegistry. J Am Coll Cardiol 2012; 59: 991–7.
• 2.Jeroudi OM, Alomar ME, Michael TT, et all.Prevalence and management of coronary chronictotal occlusions in a tertiary Veterans Affairshospital. Catheter Cardiovasc Interv 2014; 84:637–43.
• 3.Stone GW, Kandzari DE, Mehran R, et all.Percutaneous recanalization of chronically occludedcoronary arteries: a consensus document: part I.Circulation 2005; 112:2364–72.