Doku Mühendisliğinde Diş Dokusundan Türetilmiş Mezenkimal Kök Hücreler

Yıl 2021, Cilt: 7 Sayı: 1, 1 - 15, 22.06.2021

Abdulkareem Almarrawı

Öz

Doku mühendisliğ, “Mühendislik ve yaşam bilimlerinin ilkelerini, doku işlevini veya bütün bir organı restore eden, koruyan veya geliştiren biyolojik ikamelerin gelişimine uygulayanan disiplinler arası bir alandır.” Doku mühendisliği hücreleri, iskele ve sinyal moleküllerini kullanarak yenilenmiş dokular oluşturur. Mezenkimal kök hücreler, doku mühendisliği uygulamalarında en çok kullanılan popülasyonlar arasındadır. Kök hücre multipotent bir hücre olup, spesifik hücreye çoğalabilir ve farklılaşabilir. Bu hücreler birçok farklı doku tipini oluşturma kapasitesine sahiptir. Kemik iliğinde multipoten mezenkimal kök hücrelerin keşfinden beri, diğer dokulardaki mezenkimal kök hücreler tanımlanmıştır. Diş dokuları, mezenkimal kök hücrelerin izolasyonu için potansiyel bir kaynak olarak kabul edilmiştir. Bugüne kadar, diş dokularından bircok mezenkimal kök hücre izole ve karakterize edilmiştir. Bu makale, mezenkimal kök hücrelerin dental kaynaklarını ve bu dental dokudan türetilmiş mezenkimal kök hücrelerin özelliklerini gözden geçirecektir.

Anahtar Kelimeler

Doku Mühendisliği, Diş Dokusu, Mezenkimal Kök Hücreler

Dental Tissue-Derived Mesenchymal Stem Cells in Tissue Engineering

Öz

Tissue engineering (TE) is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue or organ function. TE provides newly regenerated tissues by the appliance of cells, scaffold, and signaling molecules. In tissue engineering applications, mesenchymal stem cells are among the most-used populations. The stem cell is a multipotent cell, which can proliferate and differentiate to a specific cell. These cells can form many different tissue types. Since the discovery and characterization of multipotent mesenchymal stem cells (MSCs) from bone marrow (BM), MSC-like populations from other tissues have now been characterized based on the ‘gold standard’ criteria established for BMMSCs. Dental issues have been considered as a potential source for the isolation of MSC-like populations. To date, many unique populations of dental tissue-derived MSCs have been isolated and characterized. This article will review the current dental sources of MSCs, and the properties of these dental tissue-derived MSCs.

Anahtar Kelimeler

Tissue Engineering (TE), Dental Tissue, Mesenchymal Stem Cells (MSCs)

Kaynakça

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