Biological activities of some transition metal complexes derived from N,N -bis salicylidene -1,2-bis- o - and p - aminophenoxy ethan

Yıl 2013, Cilt: 2 Sayı: 1, 16 - 19, 01.06.2013

Hamdi Temel Hasan Uçmak Salih Paşa Mustafa A. Yılmaz Salih Hoşoğlu

Öz

The Schiff base ligands N,N -bis salicylidene -1,2-bis- o-aminophenoxy ethane L1 and N,N -bis salicylidene 1,2-bis- p-aminophenoxy ethane L2 were synthesized for this study. The Cu II , Ni II , Zn II complexesof L1 and the Cu II , Co II , Zn II complexes of L2 were obtained with various transition metal salts.These compounds were evaluated against to the common infectious bacteria in human such as E. coli,Pseudomonas, Acinetobacter and Staphylococcus strains. The copper complexes of both L1 and L2 were foundeffective against Staphylococcus strains. Staphylococcus strains are common pathogens in hospital environment.Thus, their copper complexes L1-Cu and L2-Cu may be useful in hospital hygiene

Anahtar Kelimeler

Transition metal complex, Antimicrobial activity, transition metal

N,N-Bis(salisiliden)-1,2-bis -(o - ve p - aminofenoksi)etandan elde edilen bazı geçişli metal komplekslerinin biyolojik aktiviteleri

Öz

Bu çal›flma için N,N -bis(salisiliden)-1,2-bis-(o-aminofenoksi)etan (L1) ve N,N -bis(salisiliden)-1,2-bis-(paminofenoksi)etan (L2) Schiff bazlar› sentezlendi. Bu ligandlardan da L1’in Cu(II), Ni(II), Zn(II) kompleksleri, L2’nin Cu(II), Co(II), Zn(II) kompleksleri elde edildi. Sentez sonras› elde edilen bu bileflikler, insanlarda yayg›n olarak görülen bulafl›c› bakteriler E. coli, Pseudomonas, Acinetobacter ve Staphylococcus’a karfl› etkinlikleri incelenmifltir. Her iki ligand›n da bak›r kompleksleri Staphylococcus’a karfl› etkili oldu¤u bulunmufltur. Staphylococcus, hastane çevresinde yayg›n olarak görülen patojenlerdendir. Bu yüzden bu ligandlar›n bak›r kompleksleri (L1-Cu ve L2-Cu) hastane hijyeninde kullan›fll› olabilece¤i düflünülmektedir.

Anahtar Kelimeler

salisiliden, aminofenoksi, metal kompleksler

Kaynakça

• 1. H. Temel, Ü. Çak›r, B. Otludil, H. ‹. U¤rafl, Synthesis, Synth. React. Inorg. Met.-Org. Chem., 31 (8) (2001) 1323-1337.
• 2. H. Temel, S. ‹lhan, M. fiekerci, R. Ziyadano¤ullar›, Spectrosc. Letters, 35 (2) (2002) 219-228.
• 3. M. R. Mahmoud, M. T. El-Haty, Inorg. Nucl. Chem., 42 (1980) 349-353.
• 4. H. Temel, MBCAC III 3rd Mediterranean Basin Conference on Analytical Chemistry, Antalya, Turkey, (2000) pp. 138.
• 5. H. Temel, M. fiekerci, Synth. React. Inorg. Met.-Org. Chem. 31 (5) (2001) 849-857.
• 6. H. Temel, S. ‹lhan, M. fiekerci, M. Synth. React. Inorg. Met.-Org. Chem. 32 (9) (2002) 1625-1634.
• 7. H. Temel, H. Hoflgoren, Transition Met. Chem. 27 (6) (2002) 609-612.
• 8. H. Temel, Ü. Çak›r, H. ‹. U¤rafl, M. Sekerci, J. Coord. Chem., 56 (11) (2003) 943-951.
• 9. D. F. Spooner, G. Sykes, Methods in Microbiology, J. R. Norris; D. W. Ribbons, (Ed.) Academic, Press Inc., London, 7B (1972) 277.
• 10. A. Scozzafava, L. Menabuoni, F. Mincione, G. Mincione, C.T. Supuran, Bioorg. Med. Chem. Lett, 11 (2001) 575-582.
• 11. A. Scozzafava and C. T. Supuran J. Med. Chem, 43 (2000) 3677-3687.
• 12. G. Alzuet, J. Casanova, J. Borras, S. Garcia-Granda, A. Gutierrez-Rodriguez, C. T. Supuran, Inorganica Chimica Acta, 273 (1998) 334-338.
• 13. C. T. Supuran, A. Scozzafava Eur. J. Med. Chem, 35 (2000) 867-874.
• 14. D. R. Williams, The Metals of Life, Van Nostrand, London (1971).
• 15. R. J. P. William, Quart. Rev, 24 (1970) 331-340.
• 16. R. J. P. William, Bioinorganic Chemistry, American Chemical Society, Washington (1971).
• 17. C.T. Supuran, A. Scozzafava, L. Menabuoni, F. Mincione, F. Briganti and G. Mincione, Metal-Based Drugs 6 (1999) 67-76.
• 18. J. M. Pratt, Inorganic Chemistry of Vitamin B, Academic Press, London (1970).
• 19. S. K. Shapiro and F. Schlenk, Transmethylation and Methionine Biosynthesis, University of Chicago Press, Chicago (1965).
• 20. J. M. Walshe, Brit. J. Hospit. Med. 6 (1970) 45-52.
• 21. E. Ochial, Coord. Chem. Rev. 3 (1968) 49-60.
• 22. F. Frieden, Sci. Amer 2 (1968) 1021.
• 23. R. J. P. William, Chem. Rev. 1 (1968) 13-34.
• 24. E.Sinn, C. M. Harris, Coord. Chem. Rev. 4 (1969) 391-403