Solunum Cihazına Bağlı Pnömonili Hastalarda Soluk Havasındaki Nitrik Oksit ve Hidrojen Peroksitin Tanısal Değerleri

Öz

Serbest radikallerin özellikle nitrik oksitin (NO), akciğer hastalıklarının takibinde önemi giderek artmaktadır. Çalışmada, hasta için herhangi bir risk taşımayan, örneklemesi kolay bir yöntemle, enflamatuvar parametrelerin ölçülmesi planlandı. Solunum cihazına bağlı 37 olgu alındı ( 27 hasta, 10 kontrol). Olguların birinci ve üçüncü günlerde soluk hava yoğunlaştırıcısı ile ekspiryum hava numunesi alınarak, NO, hidrojen peroksit (H2O2) ayrıca serumdan C-reaktif protein (CRP) düzeyleri ölçüldü. Birinci gün; pnömoni grubunun NO düzeyi kontrol grubundan istatistiksel olarak daha yüksekti (p <0,0001). Birinci gün H2O2 düzeyi açısından gruplar arasında anlamlı bir farklılık yoktu (p> 0,05). Pnömoni grubunun birinci ve üçüncü gün arasındaki NO düzeyindeki düşüş istatistiksel olarak anlamlı bulundu. (p<0,05). Birinci gün bakılan serum CRP ve ekspiryum hava NO düzeyleri pnömoni grubunda anlamlı derecede yüksekti, ancak H2O2 düzeyleri arasında fark bulunmadı. Yapılan çalışmada, enflamasyonu göstermede NO ölçümünün oldukça anlamlı olduğu, özellikle solunum cihazına bağlı pnömonide erken tanıda değerli olabileceği düşünülmektedir.

Anahtar Kelimeler

• Soluk havası
• H2O2
• Solunum cihazı
• Nitrik oksit
• Pnömoni

Dıagnostıc Values of Nıtrıc Oxıde and Hydrogen Peroxıde Content ın Inspıred Aır ın Patıents wıth Pneumonıa Under Respıratory Device

Öz

Free radicals, especially nitric oxide (NO), are of increasing importance in the management of lung diseases. In this study, we aimed to measure the inflammatory parameters with a method that is easy to sample and does not carry any risk to the patient. 37 cases connected to ventilator were included (27 patients, 10 controls). The first day and the third day, expiratory air was removed with an exhaled breath condenser and NO, hydrogen peroxide (H2O2) and serum C-reactive protein (CRP) were examined. First day; The NO level of the pneumonia group was statistically higher than the control group (p <0,0001). No significant difference was found between the patients in terms of hydrogen peroxide level at the first day (p> 0,05).The decrease in NO level between the first and third days of the pneumonia group was found to be statistically significant. (p<0,05). Serum CRP and exhaled air NO levels were significantly higher in the pneumonia group on the first day compared to the control group, but no difference was found between the H2O2 values. In our study, it is thought that NO is very significant in showing inflammation and may be valuable in early diagnosis, especially in respiratory device-associated pneumonia.

Anahtar Kelimeler

• Exhaled air
• H2O2
• Mechanical ventilation
• Nitric oxide
• Pneumonia

Kaynakça

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