Pulmoner Tromboemboli hastalarında d-Dimer/ troponin T oranının klinik önemi

Öz

Amaç: d-Dimer ve hsTT, pulmoner tromboembolizm (PTE) için kullanılan biyokimyasal belirteçlerdir. Bu iki parametre arasındaki oranın klinik önemi üzerine çok az çalışma vardır. Amacımız, PTE için yeni parametre d-Dimer / hsTT oranı bulmaktır. Dolayısıyla bu yeni oran, diğer tromboembolik olaylardan PTE’yi ayırt etmek için önemli olabilir. Gereç ve Yöntem: Çalışmaya 2014-2017 yılları arasında Ankara Numune Eğitim ve Araştırma Hastanesi Acil Servisi'ne başvuran ve PTE ön tanısıyla BT pulmoner anjiyografi (BTPA) çekilen hastalar dahil edildi. Hastaların bilgisayarlı tomografi raporları değerlendirildi. Saptanan patolojiler ve pulmoner tromboembolizm varlığı kaydedildi. Hastaların d-dimer ve hsTT değerlerinin oranı hesaplandı ve mortalite durumu kaydedildi. Sonuçlar: İki grup arasında d-Dimer ve hsTT açısından istatistiksel olarak anlamlı fark varken (sırasıyla p = 0,001 ve p <0,001), d-Dimer / hsTT oranı açısından fark yoktu (p = 0,199). Tartışma: Literatür ile karşılaştırıldığında, farklı kardiyak troponinlerin d-Dimer / Troponin oranı için incelendiğini ve bir standart olmadığını bulduk. Bununla birlikte, çalışmaların çoğu kötü prognoz açısından kardiyak enzim sonuçlarının önemini vurgulamıştır.

Anahtar Kelimeler

• d-Dimer,
• troponin
• pulmoner tromboemboli

The clinical significance of D-dimer/troponin T ratio in patients with pulmonary thromboembolism

Öz

Purpose: d-Dimer and hsTT are biochemical markers used for pulmonary thromboembolism (PTE). There are very few studies on the clinical significance of the ratio between these two parameters. Our aim is finding new parameter d-Dimer/hsTT ratio for PTE. So this new ratio can be important to distinguish from other thromboembolic events. Materials and Methods: The study included patients who were admitted to the Emergency Department of Ankara Numune Training and Research Hospital and underwent CT pulmonary angiogram (CTPA) with pre-diagnosis of PTE between 2014-2017. The computed tomography reports of the patients were also evaluated. The detected pathologies and pulmonary thromboembolism presence were recorded. The ratio of d-dimer and hsTT values of the patients were calculated and mortality were recorded. Results: While there was a statistically significant difference between the two groups in terms of d-Dimer and hsTT (p = 0.001 and p <0.001, respectively), there was no difference in terms of d-Dimer/hsTT (p = 0.199). Conclusion: Compared with the literature, we have found that different cardiac troponins are examined for d-Dimer/Troponin ratio and that there is no standard. However, most of the studies have emphasized the significance of cardiac enzyme results in terms of poor prognosis.

Anahtar Kelimeler

• d-Dimer
• troponin
• pulmonary thromboembolism

Kaynakça

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