Bibliometric Analysis of Studies on the Effects of Hyperthyroidism on Heart Health

Abstract

In recent years, the effects of hyperthyroidism on the cardiovascular system and other organs have become a growing area of research. Clinical conditions such as arrhythmia, increased cardiac output, hypertension, and atrial fibrillation have drawn considerable attention within the field of physiology. This study aims to identify and map the scientific literature published over the past two decades on the effects of hyperthyroidism on heart health through a bibliometric approach. A total of 485 articles indexed in the Scopus database between 2004 and 2024 were analyzed using R software and VOSviewer. According to the results, China had the highest number of publications, while the United States was identified as the most productive country. The United Kingdom stood out for its high level of international collaboration. Lip G.Y.H. was the most prolific author, contributing 18 publications. The most frequently used keywords were “atrial fibrillation” and “hyperthyroidism,” and the Journal of Clinical Endocrinology and Metabolism was the leading journal in terms of output. The findings reveal a clear upward trend in research interest regarding the cardiovascular effects of hyperthyroidism. This study provides a comprehensive overview of the existing literature and highlights key contributors, collaborative networks, and emerging themes offering valuable insights, especially for early-career researchers interested in this field.

Keywords

• Bibliometric analysis
• biblioshiny
• heart health
• hyperthyroid
• hyperthyroidism
• vosviewer

Hipertiroidizmin Kalp Sağlığına Etkisi Hakkında Yapılan Çalışmaların Bibliyometrik Analizi

Öz

Hipertiroidizmin kardiyovasküler sistem ve diğer organlar üzerindeki etkileri, son yıllarda önemli bir araştırma konusu haline gelmiştir. Aritmi, artmış kalp debisi, hipertansiyon ve atriyal fibrilasyon gibi klinik belirtiler, fizyoloji alanında da ilgi görmektedir. Bu çalışma, bibliyometrik analiz yöntemiyle hipertiroidizmin kalp sağlığına etkilerini inceleyen son 20 yıldaki araştırmaları belirlemeyi amaçlamaktadır. Scopus veri tabanında indekslenen, 2004-2024 yılları arasında yayımlanan 486 makale, R programı ve VOSviewer ile analiz edilmiştir. Sonuçlara göre, Çin bu alanda en fazla araştırma yapan ülke olurken, ABD en üretken, Birleşik Krallık ise en çok iş birliği yapan ülke olarak belirlenmiştir. Lip GYH, 18 makale ile en çok yayın yapan yazar olmuştur. En sık kullanılan anahtar kelimeler “atriyal fibrilasyon” ve “hipertiroidizm” olup, Journal of Clinical Endocrinology and Metabolism en üretken dergi olarak öne çıkmıştır. Son yıllarda hipertiroidizmin kalp sağlığı üzerindeki etkilerine yönelik ilginin arttığı görülmektedir. Bu çalışma, özellikle yeni araştırmacılar için önemli iş birliklerini ve öne çıkan araştırma alanlarını belirlemeye katkı sağlamaktadır.

Anahtar Kelimeler

• Biblioshiny
• bibliyometrik analiz
• hipertroid
• hipertiroidizm
• kalp sağlığı
• voswiever

Kaynakça

1. De Leo S, Lee, SY, Braverman LE (2016). Hyperthyroidism. Lancet., 388(10047):906-918.
2. Panagoulis C, Halapa A, Chariatis E, Driva P, Matsakas E (2008). Hyperthyroidism and the heart. Hellen J Cardiol., 49(3):169-175.
3. Kandan V, Sathyamurthy P, Rajkumar M, Narayanan L (2017). Cardiovascular manifestations in hyperthyroidism. Int J Res Med Sci., 4(7):3032-3038.
4. Bereda G (2022). Hyperthyroidism: Definition, causes, pathophysiology and management. Austin J Endocrinol Diabetes., 9(1):1091.
5. Dağlar G (2015). Subklinik hipertiroidi: Güncel yaklaşım. 6. Ulusal Endokrin Cerrahisi Kongresi Sunumları.
6. Ertek S, Cicero AF (2013). Hyperthyroidism and cardiovascular complications: a narrative review on the basis of pathophysiology. Arch Med Sci., 9(5):944-952.
7. Yamakawa H, Kato TS, Noh JY et al. (2021). Thyroid hormone plays an important role in cardiac function: from bench to bedside. Front. Physiol., 12:606931.
8. Dillmann WH (2002). Cellular action of thyroid hormone on the heart. Thyroid., 12(6):447-452.

9. Barreto-Chaves MLM, Senger N, Fevereiro MR et al. (2020). Impact of hyperthyroidism on cardiac hypertrophy. Endocr. Connect., 9(3):R59-R69.
10. Osuna PM, Udovcic M, Sharma MD (2017). Hyperthyroidism and the heart. Methodist Debakey Cardiovasc J., 13(2):60-63.
11. Arai M, Otsu K, MacLennan DH, Alpert NR, Periasamy M et al. (1991). Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins. Circ. Res., 69(2):266-276.
12. Iordanidou A, Hadzopoulou-Cladaras M, Lazou A (2010). Non-genomic effects of thyroid hormone in adult cardiac myocytes: relevance to gene expression and cell growth. Mol Cell Biochem., 340(1-2):291-300.
13. Vargas Uricoechea H, Bonelo Perdomo A, Sierra Torres CH (2014). Effects of thyroid hormones on the heart. Clin Investig Arterioscler., 26(6):296-309.
14. Klein, I, Danzi S (2007). Thyroid disease and the heart. Circulation., 116(15):1725-1735.
15. Nabbout LA, Robbins RJ (2010). The cardiovascular effects of hyperthyroidism. Methodist Debakey Cardiovasc J., 6(2):3-8.
16. Łacka K, Fraczek MM (2014). Podział i etiopatogeneza nadczynności tarczycy. Pol Merk Lek., 36(213):206-221.
17. Biondi B, Cooper DS (2018). Subclinical Hyperthyroidism. N Engl J Med., 378(25):2411-2419.
18. Donangelo I, Suh SY (2017). Subclinical hyperthyroidism: When to consider treatment. Am Fam Physician., 95(11):710-716.
19. Kim HJ, McLeod DSA (2024). Subclinical hyperthyroidism and cardiovascular disease. Thyroid., 34(11):1335-1345.
20. Liu J, Wu G, Li S, Cheng, L, Ye X (2024). The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study. Front Endocrinol., 15:1344282.
21. Muddasir U, Jahanger R (2024). The role of thyroid hormone in heart disease. Pak J Med Cardiol., 2(1):33-54.
22. Badridinova BK, Sh G (2024). Influence of thyroid hormonal disorders on heart remodeling. J Pedagogy Psychol Soc Res., 3(3):1-8.
23. Liu L, Cai S, Chen A et al (2024). Long-term prognostic value of thyroid hormones in left ventricular noncompaction. J Endocrinol Invest., 47(9):2185-2200.
24. Chen Y, Xiao X, He Q et al. (2024). Knowledge mapping of digital medicine in cardiovascular diseases from 2004 to 2022: A Bibliometric analysis. Heliyon., 10(3):e25318.
25. Song JL, Hu JW, Li LR et al. (2024). Association of thyroid autoimmunity with extra-thyroid diseases and the risk of mortality among adults: evidence from the NHANES. Front Endocrinol., 15:1323994.
26. Singh H, Shahid MZ, Harrison SL, Lane DA, Lip GYH, Logantha SJRJ (2024). Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: A systematic review and meta-analysis. PloS One., 19(1):e0296413.
27. Collet TH, Gussekloo J, Bauer DC et al. (2012). Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med., 172(10):799-809.
28. Selmer C, Olesen JB, Hansen ML et al. (2012). Subclinical and overt thyroid dysfunction and risk of all-cause mortality and cardiovascular events: a large population study. J Clin Endocrinol Metab., 97(7):2372-2379.
29. Tecer T, Demir G, Suner-keklik S (2024). The role of exercise in lymphedema management: a Bibliometric analysis. Izm Dem Univ Health Sci J., 7(2):144-161.
30. Demir G, Arslan R (2022). Sensitivity analysis in multi-criterion decision-making problems. AHBVÜ İktisadi ve İdari Bilimler Dergisi., 24(3):1025-1056.
31. Eralp İnan O (2024). A bibliometric analysis of thromboelastography in veterinary clinical use. Harran Univ Vet Fak Derg., 13(1):34-41.
32. Chen SQ, Gou RQ, Zhang Q (2024). The evolution and hotspots of radioactive iodine therapy in hyperthyroidism: a Bibliometric analysis. Nucl Med Comm., 46(3):204-217.
33. Chen Z, Wan H, Min T, Su S, Yang DG (2024). Thyroid dysfunction in nonvalvular atrial fibrillation and clinical outcomes. Endocrine.,86(1):239-245.
34. Yang Y, Li P, Zhou C et al. (2024). Global research landscape and emerging trends in Graves' disease: a Bibliometric analysis. Medicine., 103(24):e37963.
35. Wu Y, Cai T, Tao Y, Zhao J, Zhang J (2024). Emerging insights and global trends in the relationship between selenium and thyroid diseases: a Bibliometric analysis. Endocr Metab Immune Disord Drug Targets.,24(7):808-819.
36. Yao W, Peng X, Guan Y, Du X, Xia C, Liu F (2024). Thyroid nodules: emerging trends in detection and visualization based on citespace. Endocr Metab Immune Disord Drug Targets., 24(1):130-141.
37. Li H, Wu P (2024). Epigenetics in thyroid cancer: a Bibliometric analysis. Endocrine connections., 13(9):e240087.
38. Zhang Q, Xin X, Wang L (2022). A bibliometric analysis of 8271 publications on thyroid nodules from 2000 to 2021. Front Endocrinol., 13:845776.
39. Chen P, Feng C, Huang L, Chen H, Feng Y, Chang S (2023). Exploring the research landscape of the past, present, and future of thyroid nodules. Front Med., 9:831346.
40. Demir G, Chatterjee P, Zakeri S, Pamucar D (2024). Mapping the evolution of multi-attributive border approximation area comparison method: a Bibliometric analysis. Decis. Mak. Appl. Manag. Eng., 7(1):290-314.
41. Demir G, Chatterjee P, Pamucar D (2024). Sensitivity analysis in multi-criteria decision making: a state-of-the-art research perspective using bibliometric analysis. Expert Syst. Appl., 237:121660.
42. John J, Joseph J, Mathew L, James S, Jose J (2024). Exploring the predictive analytics Frontier in business: a Bibliometric journey. J Scientometric Res., 13(2):365-338.
43. Mahi M, Mobin MA, Habib M, Akter S (2021). A bibliometric analysis of pandemic and epidemic studies in economics: future agenda for COVID-19 research. Soc. Sci. Humanit. Open., 4(1):100165.
44. Brahmer JR, Lacchetti C, Schneider BJ et al. (2018). National comprehensive cancer network. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol., 10:36(17):1714-1768.
45. Alexander EK, Pearce EN, Brent GA et al. (2017). Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid., 27(3):315-389.
46. Demir G, Moslem S, Duleba S (2024). Artificial intelligence in aviation safety: Systematic review and biometric analysis. Int. J. Comput. Intell. Syst., 17(279):1-30.
47. Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R, Reginster JY (2013). Scientific advisory board of The European Society for Clinical and Economic Aspects of osteoporosis and osteoarthritis (ESCEO) and The Committee of Scientific Advisors of The International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int., 24(1):23-57.
48. Alkhammash R (2023). Bibliometric, network, and thematic mapping analyses of metaphor and discourse in COVID-19 publications from 2020 to 2022. Front. Psychol., 13:1062943.
49. Sarma D, Sharma D (2024). AI and robotics in education: A systematic literature review and bibliometric analysis. EAI Endorsed Trans. Scal. Inf. Syst., 11(43):e6.
50. Xie H, Liu W, Yang M (2024). A bibliometric study of the nasopharyngeal cancer immunotherapy knowledge map. Medicine., 103(16):e37763.