Analysis of The Relationship between Blood Groups and Lung Cancer Risk Depending on Histology

Öz

Aim: Blood group antigens are the first genetic markers discovered. ABO blood groups which are expressed on red blood cell membranes are reported to be associated with malignancy risk. The present study aimed to investigate whether there is an association between blood groups and patients with lung cancer. Material and Methods: In our study, ıt was reviewed 587 patients with lung cancer whose ABO/Rh blood types were serologically confirmed. Patients were classified according to blood groups (O, A, B, AB), Rh factor (+, −) and histological types of lung cancer as Non-small cell lung carcinoma (NSCLC) and Small cell lung carcinoma (SCLC). The adenocarcinoma (AC) and squamous carcinoma (SC) as subtypes of NSCLC were recorded. The relationship of ABO/Rh blood groups with clinical features, such as age, sex and histological subtype were evaluated. Results: There was no significant association between pathological results and blood groups O, A, B and AB. SCLC patients had significantly higher frequency of blood type B Rh (-) when compared to NSCLC patients. Conclusion: We observed an association between risk of lung cancer and ABO blood groups. Although the Rh factor is not effective by itself, patients with the B Rh (-) blood group may have a higher risk than SCLC. Examining the relationship of blood group subtypes with lung cancer cells at the molecular level would be useful to clarify the relationship between lung cancer and blood groups.

Anahtar Kelimeler

• blood group
• lung cancer
• antigen

Kan Grupları İle Akciğer Kanseri Riski Arasındaki İlişkilerin Histolojiye Bağlı Analizi

Öz

Amaç: Kan grubu antijenleri, keşfedilen ilk genetik belirteçlerdir. Kırmızı kan hücre zarlarından eksprese edilen ABO kan gruplarının çeşitli çalışmalarda malignite riski ile ilişkili olduğu gösterilmiştir. Bu çalışmanın amacı, kan grupları ile akciğer kanseri arasında bir ilişki olup olmadığını araştırmaktır. Gereç Yöntemler: Çalışmamızda ABO ve Rh kan grubu serolojik olarak doğrulanmış 587 akciğer kanserli hasta gözden geçirildi. Hastalar kan gruplarına (O, A, B, AB), Rh faktörü (+, -) ve histolojik akciğer kanseri tiplerine göre [Küçük Hücreli Dışı Akciğer kanseri (KHDAK) ve Küçük Hücreli Akciğer Kanseri (KHAK)] sınıflandırıldı. KHDAK’nin adenokarsinom (AK) ve skuamöz karsinom (SK) alt tipleri kaydedildi. ABO / Rh kan gruplarının yaş, cinsiyet ve histolojik alt tip gibi klinik özelliklerle ilişkisi değerlendirildi. Bulgular: Patolojik analiz sonucu ile O, A, B ve AB kan grupları arasında anlamlı bir ilişki bulunmadı. Çalışmada KHAK'li olgularda B Rh (-) kan grubuna sahip olan hastaların oranı, KHDAK'li olanlardan daha yüksek bulundu. Sonuç: Akciğer kanseri riski ile ABO kan grupları arasında bir ilişki olduğu görüldü. Rh faktörü tek başına etkili olmamakla beraber B Rh (-) kan grubuna sahip olan hastalar KHAK açısından daha fazla riske sahip olabilir. Kan grubu alt tiplerinin akciğer kanseri hücreleriyle moleküler düzeyde ilişkisinin incelenmesi, akciğer kanseri ve kan grupları arasındaki ilişkiyi açıklığa kavuşturmak için yararlı olacaktır.

Anahtar Kelimeler

• kan grubu
• akciğer kanseri
• antijen

Destekleyen Kurum

yok

Kaynakça

1. 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. 2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 5: E359-386.
3. 3. Dela Cruz Cs, Toune LT, Matthay RA. Lung Cancer: epidemilogy, etiology, and prevention. Clin Chest Med 2011; 32: 605-44.
4. 4. Couraud S, Zalcman G, Milleron B, Morin F, Souquet PJ. Lung cancer in never smokers--a review. Eur J Cancer 2012; 48: 1299-311.
5. 5. Hakomori S.Tumor-associated carbohydrate antigens defining tumor malignancy:basis for development of anticancer vaccines. Adv Exp Med Biol 2001; 491: 369-402.
6. 6. Urun Y, Utkan G, Cangir AK, Oksuzoglu OB, Ozdemir N, et al. Asian Pac J Cancer Prev 2013; 14 (5): 2801-3.
7. 7. Alvarez-Fernandez E, Carretero-Albinana L. Expression of blood group antigens by normal bronchopulmonary tissues and common forms of pulmonary carcinomas. Arch Pathol Lab Med 1991; 115: 42-9.
8. 8. Lee JS, Ro JY, Sahin AA, et al. Expression of blood-group antigen A-a favorable prognostic factor in non-small-cell lung cancer. N Engl J Med 1991; 324: 1084-90.

9. 9. Cerny T, Fey M, Oppliger R, Castiglione M, Nachbur B, Gertsch M, et al. Prevalence of the rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC). Int J Cancer 1992; 52: 504-6.
10. 10. Miyake M, Taki T, Hitomi S, Hakomori S. Correlation of expression of H/Le(y)/Le(b) antigens with survival in patients with carcinoma of the lung. N Engl J Med 1992; 327: 14-8.
11. 11. Gwin JL, Klein-Szanto AJ, Zhang SY, et al. Loss of blood group antigen A in non-small cell lung cancer. Ann Surg Oncol 1994;1:423-7.
12. 12. Ulger AF, Keklik T, Kumbasar OO, et al. Prognostic significance of blood group antigen expression of tumor tissue in lung cancer patients. Tumori 2002; 88: 395-9.
13. 13. Sanchez-Mora N, Cebollero PM, Monroy V, et al. Expression of histo-blood group antigens in bronchial squamous metaplasia. Eur Respir J 2007; 29: 268-72.
14. 14. Suadicani P, Hein HO, Gyntelberg F. ABO phenotypes and inflammation-related predictors of lung cancer mortality: the Copenhagen male study-a 16-year follow-up. Eur Respir J 2007; 30: 13-20.
15. 15. Leon-Atance P, Moreno-Mata N, Gonzalez-Aragoneses F, et al. Prognostic influence of loss of blood group A antigenexpression in pathologic stage I non-small-cell lung cancer. Arch Bronconeumol 2012;48:49-54.
16. 16. Chrysanthakopoulos NA, Dareioti NS. ABO blood group and the risk of lung cancer in Greek adults: a case-control study experimental oncology. Exp Oncol 2018; 40: 249-50.
17. 17. Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, et al. The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer. J Epidemiol 2015; 2: 110-6.
18. 18. Oguz A, Unal D, Tasdemir A, Karahan S, Aykas F, et al. Lack of any association between blood groups and lung cancer, independent of histology. Asian Pac J Cancer Prev 2013; 1: 453-6.
19. 19. Alqudah M, Allouh M, Hamouri S, Zaitoun A, Al Ghamdi N, et al. Is Rh positivity a possible risk factor for lung cancer? JJBS 2018; 11: 3: 281-4.
20. 20. Humphray SJ, Oliver K, Hunt AR, et al. DNA sequence and analysis of human chromosome 9. Nature 2004; 429: 369-74.
21. 21. Dall’olio F. Protein glycosylation in cancer biology: An overview. Clin Mol Pathol 1996; 49: 126-35.
22. 22. Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst 2009; 6: 424-31.
23. 23. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol, 2010; 11: 1280-5.
24. 24. Joh HK, Cho E, Choueiri TK. ABO blood group and risk of renal cell cancer. Cancer Epidemiol 2012; 36: 528-32.
25. 25. Urun Y, Utkan G, Yalcin S, Coskun HS, Kocer M, et al. Lack of any relationship between ABO and Rh blood groups and clinicopathological features in patients with gastrointestinal stromal tumors: Turkish Oncology Group. Asian Pac J Cancer Prev 2012; 8: 4129-31.
26. 26. Vasan SK, Hwang J, Rostgaard K, et al. ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors. Cancer Epidemiol 2016; 44: 40.
27. 27. Biswas A, Jiang Y, Li D, Mehta HJ, Kaye F. The prevalence of rhesus-negative blood group among patient with small cell lung cancer and analysis of its effect on overall survival. Front Oncol 2018; 8: 358: 1-4.
28. 28. Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A, et al. ABO blood groups are not associated with treatment response and prognosis in patients with local advanced non- small cell lung cancer. Asian Pac J Cancer Prev 2013; 6: 3945-8.
29. 29. Graziano SL, Tatum AH, Gonchoroff NJ, Newman NB, Kohman LJ. Blood group antigen A and flow cytometric analysis in resected early-stage non-small cell lung cancer. Clin Cancer Res 1997; 1: 87-93.
30. 30. Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfus 2016; 5: 434-40.