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Approach to Adnexal Masses

Yıl 2019, Cilt: 9 Sayı: 1, 25 - 30, 31.01.2019
https://doi.org/10.33631/duzcesbed.450500

Öz

Adnexal mass is
a common gynecologic problem. Most of them are benign and arise from ovary.
But, determination of adnexal mass if it has high risk of malignancy
preoperatively defining operative procedure and information of patient
appropriately is essential for preventing unnecessary procedures. In evaluation
of adnexal mass preoperatively it is necessary to use detailed history of
patient, physical examination, imaging methods and suitable tumor markers.
Recently, in order to discriminate the adnexal mass benign or malign, some
malignancy risk indexes based on ultrasound and doppler findings, tumor markers
and menopausal status of patient. International Ovarian Tumor Analysis (IOTA)
models based on ultrasound findings (septation, papillary projections, presence
of acoustic shadows, ascites), doppler imaging of adnexal mass, menopausal
status, age, family history, current hormonal therapy, presence of pain; risk
of malignancy index (RMI) including multilocularity of adnexal mass, presence
of solid component, bilaterality, presence of ascites and evidence of
metastasis, menopausal status of patient, serum CA 125 level; and De Priest
Morphological Index (MI) based on tumor volume, wall structure of cyst and
septa structure are some of these malignancy indexes. As a result of studies
that comparing scoring systems it was seen that adnexal masses could be
diagnosed with higher sensitivity and specificity by using IOTA scoring system.
Thanks to this, with more accurate evaluation of patients preoperatively, optimal
surgical method could be planned.

Kaynakça

  • 1. Ayhan A, Durukan T, Günalp S. Temel Kadın Hastalıkları ve Doğum Bilgisi. 2. Baskı. Ankara: Güneş Tıp Kitabevi; 2008. s. 943-4.
  • 2. Yüce K, Dursun P. Adneksiyal Kitle ve Erken Ovaryan Kanser. Ayhan A, çeviri editör. Klinik Jinekolojik Onkoloji. 6. Baskı. Ankara: Güneş Kitabevi; 2003. s. 259-88.
  • 3. Hillard PA. Kadın Genital Traktus Malign Hastalıkları: Semptom ve Bulgular. Berek JS, Adashi EY, Hillard PA, editörler. Novak Jinekoloji. Erk A, çeviri editör. 13. Baskı. İstanbul: Nobel Tıp Kitabevi; 2007. s. 443-541.
  • 4. Scully RE. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. In: Young RH, Clement PB. Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology; 1998. p. 51-79.
  • 5. Penson RT, Wenzel LB, Vergote I, Cella D. Quality of life considerations in gynecologic cancer. FIGO 6th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet. 2006; 95(Suppl 1): S247-57.
  • 6. Webb PM, Purdie DM, Grover S, Jordan S, Dick ML, Green AC. Symptoms and diagnosis of borderline, early and advanced epithelial ovarian cancer. Gynecol Oncol. 2004; 92(1): 232-9.
  • 7. Ayhan A, Yapar E. Overin Malign Hastalıkları. Atasü T, Aydınlı K, editörler. Jinekolojik Onkoloji. İstanbul: Logos Tıp Yayıncılık; 1997. s. 198-243.
  • 8. Le T, Krepart GV, Lotocki RJ, Heywood MS. Does debulking surgery improve survival in biologically aggressive ovarian carcinoma? Gynecol Oncol. 1997; 67(2): 208-14.
  • 9. Tingulstad S, Hagen B, Skjeldestad FE, Onsrud M, Kiserud T. Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre-operative diagnosis of pelvic masses. Br J Obstet Gynaecol. 1996; 103(8): 826-31.
  • 10. Manjunath AP, Pratapkumar, Sujatha K, Vani R. Comparison of three risk of malignancy indices in evaluation of pelvic masses. Gynecol Oncol .2001; 81(2): 225-9.
  • 11. Jacobs IJ, Oram D, Fairbanks J, Turner J, Frost C, Grudzinskas JG. A risk of malignancy index incorporating CA125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Br J Obstet Gynaecol. 1990; 97(10): 922-9.
  • 12. Yavuzcan A, Çağlar M, Özgü E. Should cut-off values of the risk of malignancy index be changed for evaluation of adnexal masses in Asian and Pacific Populations? Asian Pac J Cancer. 2013; 14(9): 5455-9. 13. Yavuzcan A, Çağlar M, Özgü E. Addition of parity to the risk of malignancy index score in evaluating adnexal mass. TJOG. 2014; 53(4): 518-22.
  • 14. Lerner JP, Timor-Tritsch IE, Federman A, Abramovich G. Transvaginal ultrasonographic characterization of ovarian masses with an improved, weighted scoring system. Am J Obstet Gynecol. 1994; 170(1): 81-5.
  • 15. DePriest PD, Varner E, Powell J, Fried A, Puls L, Higgins R. The efficacy of a sonographic morphology index in identifying ovarian cancer: A multi-institutional investigation. Gynecol Oncol. 1994; 55(2): 174-8.
  • 16. Ueland FR, DePriest PD, Pavlik EJ, Kryscio RJ, van Nagell JR. Preoperative differentiation of malignant from benign ovarian tumors: The efficacy of morphology indexing and Doppler flow sonography. Gynecol Oncol. 2003; 91(1): 46-50. 17. Sassone AM, Timor-Tritsch IE, Artner A, Westhoff C, Warren WB. Transvaginal sonographic characterization of ovarian disease: Evaluation of a new scoring system to predict ovarian malignancy. Obstet Gynecol. 1991; 78(1): 70-6.
  • 18. Geomini P, Kruitwagen R, Bremer GL, Cnossen J, Mol BW. The accuracy of risk scores in predicting ovarian malignancy: A systematic review. Obstet Gynecol. 2009; 113(2): 384-94.
  • 19. Ries LA, Miller BA, Hankey BF, Kosary CL, Edwards BK. SEER Cancer Statistics Review, 1973-1995. Bethesda, Maryland: National Cancer Institute; 1998.
  • 20. Timmerman D, Testa AC, Bourne T, Ferrazzi E, Ameye L. Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: A multicenter study by the International Ovarian Tumor Analysis Group. J Clin Oncol. 2005; 23(34): 8794-801.
  • 21. Van Holsbeke C, Van Calster B, Testa AC. Ovarian cancer screening. Clin Cancer Res. 2009; 15(2): 684-91.
  • 22. Timmerman D. Lack of standardization in gynecological ultrasonography. Ultrasound Obstet Gynecol. 2000; 16(5): 395-8.
  • 23. Granberg S, Wikland M, Jansson I. Macroscopic characterization of ovarian tumors and the relation to the histological diagnosis: Criteria to be used for ultrasound evaluation. Gynecol Oncol. 1989; 35(2): 139-44.
  • 24. Timmerman D, Schwarzler P, Collins WP. Subjective assessment of adnexal masses with the use of ultrasonography: An analysis of interobserver variability and experience. Ultrasound Obstet Gynecol. 1999; 13(1): 11-6.
  • 25. Twickler DM, Forte TB, Santos-Ramos R, McIntire D, Harris P, Miller DS. The ovarian tumor index predicts risk for malignancy. Cancer. 1999; 86(11): 2280-90.
  • 26. Menon U, Gentry-Maharaj A, Hallett R. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: Results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol. 2009; 10(4): 327-40.
  • 27. Twickler M, Moschos E. Ultrasound and assessment of ovarian cancer risk. AJR Women’s Imaging. 2010; 194(2): 322-9.
  • 28. Lu C, Van Gestel T, Suykens JAK, Van Huffel S, Vergote I, Timmerman D. Preoperative prediction of malignancy of ovarian tumor using least squares support vector machines. Artif Intell Med. 2003; 28(3): 281-306.
  • 29. Van Holsbeke C, Van Calster B, Bourne T, Ajossa S. External validation of diagnostic models to estimate the risk of malignancy in adnexal masses. Clin Cancer Res. 2012; 18(3): 815-25.
  • 30. Van Calster B, Timmerman D, Valentin L. Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol. BJOG. 2012; 119(6): 662-71.

Adneksiyal Kitlelere Yaklaşım

Yıl 2019, Cilt: 9 Sayı: 1, 25 - 30, 31.01.2019
https://doi.org/10.33631/duzcesbed.450500

Öz

Adneksiyal
kitle sık karşılaşılan jinekolojik bir problemdir. Çoğunluğu over orijinlidir
ve benigndir. Ancak adneksiyal kitlelerin preoperatif olarak ovarian bir
malignansi açısından yüksek riskli olup olmadığının tespiti, uygulanacak
operatif prosedürün belirlenmesi, hastanın uygun şekilde bilgilendirilmesi
gereksiz işlem yapılmasını önlemek için çok önemlidir. Adneksiyal kitlelerin
preoperatif değerlendirilmesinde ayrıntılı anamnez, fizik muayene, görüntüleme
yöntemleri ve uygun tümör belirteçlerinin kullanımı gerekmektedir. Adneksiyal
kitlelerin malign-benign ayrımında kullanılmak üzere son yıllarda ultrasonografi
ve doppler bulguları, tümör markırları ve hastanın menopozal durumuna dayanan
çeşitli malignite risk indeksleri geliştirilmiştir. Ultrasonografi bulguları,
adneksiyal kitlenin doppler incelemesi, menopozal durum, yaş, aile öyküsü,
hormonal terapi alınıp alınmadığı ve ağrı durumunun birlikte değerlendirildiği
Uluslararası Over Tümörü Analizi (International Ovarin Tumour Analysis-IOTA)
kriterleri, kitlede multilokülasyon olup olmadığı, solid komponentlerin olup
olmadığı, bilateralite, asit ve metastaz bulgularının olup olmadığı, hastanın
menopozal durumu, serum CA-125 düzeyinin baz alındığı malignite risk indeksi,
tümör hacmi, kist duvar yapısı ve septa yapısının değerlendirildiği morfolojik
indeks bunlardan bazılarıdır. Skorlama sistemleri arasında yapılan
karşılaştırılmalı çalışmalar sonucunda IOTA skorlaması ile daha yüksek
sensitivite ve spesifite ile adneksiyal kitleye tanı koyulabileceği
görülmüştür. Bu sayede hastaların preoperatif olarak daha doğru bir şekilde
değerlendirilmesiyle optimal cerrahi yöntem planlanabilecektir.

Kaynakça

  • 1. Ayhan A, Durukan T, Günalp S. Temel Kadın Hastalıkları ve Doğum Bilgisi. 2. Baskı. Ankara: Güneş Tıp Kitabevi; 2008. s. 943-4.
  • 2. Yüce K, Dursun P. Adneksiyal Kitle ve Erken Ovaryan Kanser. Ayhan A, çeviri editör. Klinik Jinekolojik Onkoloji. 6. Baskı. Ankara: Güneş Kitabevi; 2003. s. 259-88.
  • 3. Hillard PA. Kadın Genital Traktus Malign Hastalıkları: Semptom ve Bulgular. Berek JS, Adashi EY, Hillard PA, editörler. Novak Jinekoloji. Erk A, çeviri editör. 13. Baskı. İstanbul: Nobel Tıp Kitabevi; 2007. s. 443-541.
  • 4. Scully RE. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. In: Young RH, Clement PB. Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology; 1998. p. 51-79.
  • 5. Penson RT, Wenzel LB, Vergote I, Cella D. Quality of life considerations in gynecologic cancer. FIGO 6th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet. 2006; 95(Suppl 1): S247-57.
  • 6. Webb PM, Purdie DM, Grover S, Jordan S, Dick ML, Green AC. Symptoms and diagnosis of borderline, early and advanced epithelial ovarian cancer. Gynecol Oncol. 2004; 92(1): 232-9.
  • 7. Ayhan A, Yapar E. Overin Malign Hastalıkları. Atasü T, Aydınlı K, editörler. Jinekolojik Onkoloji. İstanbul: Logos Tıp Yayıncılık; 1997. s. 198-243.
  • 8. Le T, Krepart GV, Lotocki RJ, Heywood MS. Does debulking surgery improve survival in biologically aggressive ovarian carcinoma? Gynecol Oncol. 1997; 67(2): 208-14.
  • 9. Tingulstad S, Hagen B, Skjeldestad FE, Onsrud M, Kiserud T. Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre-operative diagnosis of pelvic masses. Br J Obstet Gynaecol. 1996; 103(8): 826-31.
  • 10. Manjunath AP, Pratapkumar, Sujatha K, Vani R. Comparison of three risk of malignancy indices in evaluation of pelvic masses. Gynecol Oncol .2001; 81(2): 225-9.
  • 11. Jacobs IJ, Oram D, Fairbanks J, Turner J, Frost C, Grudzinskas JG. A risk of malignancy index incorporating CA125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Br J Obstet Gynaecol. 1990; 97(10): 922-9.
  • 12. Yavuzcan A, Çağlar M, Özgü E. Should cut-off values of the risk of malignancy index be changed for evaluation of adnexal masses in Asian and Pacific Populations? Asian Pac J Cancer. 2013; 14(9): 5455-9. 13. Yavuzcan A, Çağlar M, Özgü E. Addition of parity to the risk of malignancy index score in evaluating adnexal mass. TJOG. 2014; 53(4): 518-22.
  • 14. Lerner JP, Timor-Tritsch IE, Federman A, Abramovich G. Transvaginal ultrasonographic characterization of ovarian masses with an improved, weighted scoring system. Am J Obstet Gynecol. 1994; 170(1): 81-5.
  • 15. DePriest PD, Varner E, Powell J, Fried A, Puls L, Higgins R. The efficacy of a sonographic morphology index in identifying ovarian cancer: A multi-institutional investigation. Gynecol Oncol. 1994; 55(2): 174-8.
  • 16. Ueland FR, DePriest PD, Pavlik EJ, Kryscio RJ, van Nagell JR. Preoperative differentiation of malignant from benign ovarian tumors: The efficacy of morphology indexing and Doppler flow sonography. Gynecol Oncol. 2003; 91(1): 46-50. 17. Sassone AM, Timor-Tritsch IE, Artner A, Westhoff C, Warren WB. Transvaginal sonographic characterization of ovarian disease: Evaluation of a new scoring system to predict ovarian malignancy. Obstet Gynecol. 1991; 78(1): 70-6.
  • 18. Geomini P, Kruitwagen R, Bremer GL, Cnossen J, Mol BW. The accuracy of risk scores in predicting ovarian malignancy: A systematic review. Obstet Gynecol. 2009; 113(2): 384-94.
  • 19. Ries LA, Miller BA, Hankey BF, Kosary CL, Edwards BK. SEER Cancer Statistics Review, 1973-1995. Bethesda, Maryland: National Cancer Institute; 1998.
  • 20. Timmerman D, Testa AC, Bourne T, Ferrazzi E, Ameye L. Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: A multicenter study by the International Ovarian Tumor Analysis Group. J Clin Oncol. 2005; 23(34): 8794-801.
  • 21. Van Holsbeke C, Van Calster B, Testa AC. Ovarian cancer screening. Clin Cancer Res. 2009; 15(2): 684-91.
  • 22. Timmerman D. Lack of standardization in gynecological ultrasonography. Ultrasound Obstet Gynecol. 2000; 16(5): 395-8.
  • 23. Granberg S, Wikland M, Jansson I. Macroscopic characterization of ovarian tumors and the relation to the histological diagnosis: Criteria to be used for ultrasound evaluation. Gynecol Oncol. 1989; 35(2): 139-44.
  • 24. Timmerman D, Schwarzler P, Collins WP. Subjective assessment of adnexal masses with the use of ultrasonography: An analysis of interobserver variability and experience. Ultrasound Obstet Gynecol. 1999; 13(1): 11-6.
  • 25. Twickler DM, Forte TB, Santos-Ramos R, McIntire D, Harris P, Miller DS. The ovarian tumor index predicts risk for malignancy. Cancer. 1999; 86(11): 2280-90.
  • 26. Menon U, Gentry-Maharaj A, Hallett R. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: Results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol. 2009; 10(4): 327-40.
  • 27. Twickler M, Moschos E. Ultrasound and assessment of ovarian cancer risk. AJR Women’s Imaging. 2010; 194(2): 322-9.
  • 28. Lu C, Van Gestel T, Suykens JAK, Van Huffel S, Vergote I, Timmerman D. Preoperative prediction of malignancy of ovarian tumor using least squares support vector machines. Artif Intell Med. 2003; 28(3): 281-306.
  • 29. Van Holsbeke C, Van Calster B, Bourne T, Ajossa S. External validation of diagnostic models to estimate the risk of malignancy in adnexal masses. Clin Cancer Res. 2012; 18(3): 815-25.
  • 30. Van Calster B, Timmerman D, Valentin L. Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol. BJOG. 2012; 119(6): 662-71.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derlemeler
Yazarlar

Huri Güvey

Yayımlanma Tarihi 31 Ocak 2019
Gönderilme Tarihi 2 Ağustos 2018
Yayımlandığı Sayı Yıl 2019 Cilt: 9 Sayı: 1

Kaynak Göster

APA Güvey, H. (2019). Adneksiyal Kitlelere Yaklaşım. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 9(1), 25-30. https://doi.org/10.33631/duzcesbed.450500
AMA Güvey H. Adneksiyal Kitlelere Yaklaşım. DÜ Sağlık Bil Enst Derg. Ocak 2019;9(1):25-30. doi:10.33631/duzcesbed.450500
Chicago Güvey, Huri. “Adneksiyal Kitlelere Yaklaşım”. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 9, sy. 1 (Ocak 2019): 25-30. https://doi.org/10.33631/duzcesbed.450500.
EndNote Güvey H (01 Ocak 2019) Adneksiyal Kitlelere Yaklaşım. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 9 1 25–30.
IEEE H. Güvey, “Adneksiyal Kitlelere Yaklaşım”, DÜ Sağlık Bil Enst Derg, c. 9, sy. 1, ss. 25–30, 2019, doi: 10.33631/duzcesbed.450500.
ISNAD Güvey, Huri. “Adneksiyal Kitlelere Yaklaşım”. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 9/1 (Ocak 2019), 25-30. https://doi.org/10.33631/duzcesbed.450500.
JAMA Güvey H. Adneksiyal Kitlelere Yaklaşım. DÜ Sağlık Bil Enst Derg. 2019;9:25–30.
MLA Güvey, Huri. “Adneksiyal Kitlelere Yaklaşım”. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 9, sy. 1, 2019, ss. 25-30, doi:10.33631/duzcesbed.450500.
Vancouver Güvey H. Adneksiyal Kitlelere Yaklaşım. DÜ Sağlık Bil Enst Derg. 2019;9(1):25-30.