Melatonin and Antioxidant Effects

Yıl 2019, Cilt: 9 Sayı: 3, 196 - 201, 30.09.2019

Nurhayat Atasoy

https://doi.org/10.33631/duzcesbed.492547

Cited By: 4

Öz

Biosynthesis and chemical structure of melatonin,
the main hormone secreted from the pineal gland, although its existence has
been known since ancient times it appeared in 1958 by Lerner. Melatonin is
responsible for circadian regulation and sleep control in the organism at the
highest concentration throughout the night. In blood shows a circadian rhythm
and night values are much higher than day levels. The other important function
of melatonin is thought to be a strong free radical scavenger at extreme level.
Melatonin can extinguish both reactive oxygen species and reactive nitrogen
species. It is known that melatonin also catches the very toxic hydroxyl
radical, peroxy nitrite anion and peroxyl radical. Melatonin also inhibits
nitric oxide synthetase, a prooxidative enzyme in some places. It is also known
that for the superoxide dismutase enzyme, also stimulate the mRNA level for the
superoxide dismutase enzyme and glucose-6 phosphate dehydrogenase are
activated. The aim of the review is to emphasize once again the importance that
melatonin is a very powerful antioxidant as a result of both in vivo and in
vitro experiments.

Anahtar Kelimeler

Melatonin, antioxidant, free radical, photoperiodism, sleep

Melatonin ve Antioksidan Etkileri

Öz

Çok
eski zamanlardan beri varlığı bilinmesine rağmen pineal bezden salgılanan temel
hormon olan melatoninin biyosentezi ve kimyasal yapısı ancak 1958’de Lerner
tarafından ortaya konulabilmiştir. Melatonin gece boyunca en yüksek
konsantrasyonda organizmada karşılaşılan sirkadiyen düzenleme ve uyku
kontrolünden sorumludur. Kanda sirkadiyen bir ritim gösterir, gece değerleri
ise gündüz seviyelerinden oldukça yüksektir. Melatoninin diğer önemli
fonksiyonunun son derece güçlü serbest bir radikal temizleyici olduğu
düşünülmektedir. Melatonin hem reaktif oksijen türlerini hem de reaktif azot
türlerini etkisiz hale getirebilir. Melatoninin aynı zamanda çok toksik olan
hidroksil radikalini, peroksi nitrit anyonu ve peroksil radikalini yakaladığı
bilinmektedir. Melatonin bazı yerlerde bir prooksidatif enzim olan nitrik oksit
sentetazı da inhibe etmektedir. Ayrıca süperoksit dismutaz enzimi için mRNA
düzeyini sitümüle etmekte ve glutatyon peroksidaz, glutatyon redüktaz ve
glukoz-6 fosfat dehidrojenazı aktive ettiği de bilinmektedir. Derlemenin amacı
hem in vivo hem de in vitro yapılan deneyler sonucunda melatoninin çok güçlü
bir antioksidan olduğunun önemini bir kez daha vurgulamaktır.

Anahtar Kelimeler

Melatonin, Antioksidan Madde, Serbest Radikal, Fotoperiyodizm, uyku

Kaynakça

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