Yeni Benzimidazol Bileşiklerinin Sentezi, Antioksidan ve Antiüreaz Aktiviteleri

Yıl 2023, Cilt: 2 Sayı: 2, 60 - 76, 31.07.2023

Hakan Akgün , Taner İlker Gümrükçüoğlu , Hakan Bektaş , Bahar Bilgin Sökmen

https://doi.org/10.59312/ebshealth.1326437

Cited By: 1

Öz

Bu çalışmada, yeni bir seri benzimidazol türevi (1-5) sentezlenerek antioksidan ve antiüreaz aktiviteleri spektrofotometrik metotlarla incelendi. Sentezlenen yeni benzimidazol bileşiklerinin antioksidan aktiviteleri, DPPH (1,1-difenil-2-pikrilhidrazil) serbest radikal süpürme aktivitesi, ABTS (2,2'-azino-bis(3-etilbenzotiazolin-6-sülfonik asit) diamonyum tuzu) radikal süpürme aktivitesi, antiüreaz aktivite tayini ve demir indirgeme gücü gibi metodlarla tayin edildi. Antioksidanlar, reaktif oksijen çeşitlerinin meydana gelmesinin önlemek ve bunların oluşturmuş olduğu tahribatı engellemek için vücutta var olan bir tür savunma mekanizmalarıdır. Serbest radikalleri nötralize etmek amacıyla kullanılırlar. Antioksidan aktivitesinin kanıtı açıkça bizlere vücutta oluşabilecek hastalıklara karşı savunma mekanizmasının varlığını sergilemektedir. Elde edilen deneysel bulgulardan, benzimidazol bileşiklerinden özellikle 4 numaralı bileşiğin antioksidan aktivite değerlerinin diğer bileşiklere oranla daha yüksek olduğu saptandı. Tüm test bileşikleri, standart üreaz inhibitöründen (tiyoüre) daha yüksek aktivite gösterdi. En yüksek ve en düşük antiüreaz aktivite gösteren bileşikler sırasıyla 1 ve 5 numaralı bileşikler olarak belirlendi.

Anahtar Kelimeler

ABTS aktivitesi, Antioksidan aktivite, Antiüreaz aktivite, Benzimidazol türevleri, Demir indirgeme gücü, DPPH aktivitesi

Destekleyen Kurum

Giresun Üniversitesi BAP

Proje Numarası

FEN-230123-03

Teşekkür

Makalenin tüm aşamalarında yapmış oldukları katkılardan dolayı editör kurulu ve hakemlere teşekkür ederiz.

Synthesis, Antioxidant and Antiurease Activities of Novel Benzimidazole Compounds

Öz

In this study, a new series of benzimidazole derivatives (1-5) were synthesized and their antioxidant and antiurease activities were investigated by spectrophotometric methods. Antioxidant activities of synthesized new benzimidazole compounds, DPPH (1,1-diphenyl-2-picrylhydrazil) free radical scavenging activity, ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) radical scavenging activity were determined by methods such as antiurease activity assay and iron reducing power. Antioxidants are a kind of defense mechanism in the body to prevent the formation of reactive oxygen species and to prevent the damage they have caused. They are used to neutralize free radicals. Evidence of antioxidant activity clearly shows us that there is a defense mechanism against diseases that may occur in the body. From the experimental findings obtained, the antioxidant activity values of benzimidazole compounds, especially the number 4 compound, were found to be higher than the other compounds. All test compounds showed higher activity than the standard urease inhibitor (thiourea). Compounds with the highest and lowest antiurease activity were determined as compounds 1 and 5, respectively

Anahtar Kelimeler

ABTS activity, Antioxidant activity, Antiurease activity, Benzimidazole derivatives, Iron reducing power, DPPH activity

Proje Numarası

FEN-230123-03

Kaynakça

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