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Effect of Irradiation Dose and Storage Time on the EPR Signal Intensities of Gamma Irradiated Sulfapyridine

Yıl 2016, Cilt: 3 Sayı: 3, 0 - 0, 30.09.2016
https://doi.org/10.31202/ecjse.258565

Öz

Abstract:The interest in sterilizing the medicine using gamma energy is increasing. However, radiation may cause molecular degradation in the sample and thus may lead to the formation of free radicals due to high energy. This study aims to determine the radiation sensitivity of sulfapyridine (SU) irradiated with a predetermined dose using EPR spectroscopy. In the EPR spectra recorded at room temperature prior to radiation process, no EPR signal was observed. However, after the irradiation with gamma rays, EPR signal intensity increased significantly based on the irradiation dose.Mathematical functions and correlation coefficients were calculated determining the relation between the increasing radiation doses on the signal intensities of the sample. The stability of the free radicals created after the irradiation in time was investigated by recording the spectra of the sample irradiated with a dose value of 15 kGy in certain intervals. The results were found to be in good agreement with the existing literature data.

Kaynakça

  • Gopal, N.G.S., 1978, Radiation sterilization of pharmaceuticals and polymers. Radiation Physics and Chemistry, 12, 35-50.
  • Diehl, J.F., 2002, Food irradiation—past, present and future. Radiation Physics and Chemistry. 63, 211–215.
  • Bhat, R., Sridhar, K.R. 2011, Influence of ionizing radiation and conventional food processing treatments on the status of free radicals in lotus seeds: an EPR study. Journal of Food Composition and Analysis, 24, 563-567.
  • Ambroz, H.M., Kornacka, E.M., Marciniec, B., Przybytniak, G., 2002, Radical decay in irradiated drugs: Flutamide, ifosamide and aminglutethimide. Journal of Radioanalytical and Nuclear Chemistry, 254, 293-298.
  • Basly, J.P., Basly, I., Bernard, M., 1998a, Electron spin resonance detection of radiosterilization of pharmaceuticals: application to four nitrofurans. The Analyst, 123, 1753-1756.
  • Basly, J.P., Bernard, M., 1997, Radiosterilization dosimetry by ESR spectroscopy: ritodrine hydrochloride and comparison with other sympathomimetics. International Journal of Pharmaceutics, 149, 85-91.
  • Delincee, H., 2002. Analytical methods to identify irradiated food—a review.Radiation Physics and Chemistry, 63, 455–458.
  • Murrieta, H., Munoz, E., Adem, E., Burillo, G., Vazquez, M., Cabrera, E., 1996. Effect of irradiation dose, storage time and temperature on the ESR signal in irradiated oat, corn and wheat.Applied Radiation and Isotopes, 47, 1657-1661.
  • Ambroz, H.B., Kornacka, E.M., Marciniec, B., Ogrodowczyk, M., Przybytniak, G.K., 2000, EPR study of free radicals in some drugs γ-irradiated in the solid state. Radiation Physics and Chemistry, 58, 357-366.
  • Rajendiran, N., Siva, S., Saravanan,J., 2013, Inclusion complexation of sulfapyridine with a- and b-cyclodextrins:Spectral and molecular modeling study. Journal of Molecular Structure, 1054-1055, 215-222.
  • Challis, J.K., Carlson, J.C., Friesen, K. J., Hanson, M.K., Wong, C.S.,2013, Aquatic photochemistry of the sulfonamide antibiotic sulfapyridine. Journal of Photochemistry and Photobiology A: Chemistry, 262, 14-21.
  • Damian, G., 2003, EPR investigation of γ-irradiated anti-emetic drugs. Talanta, 60, 923-927
  • Polat, M, Korkmaz, M (2006), Journal of Pharmaceutical and Biomedical Analysis, 40: 882-888.
  • Basly, J.P., Basly, I., Bernard, M., 1998b, Electron spin resonance identification of irradiated ascorbic acid: Dosimetry and influence of powder fineness. AnalyticaChimicaActa, 372, 373-378.
  • Marralle, M., Longo, A., Panzeca, S., Gallo, S., Principato, F., Tomarchio, E., Parlato, A., Buttafava, A., Dondi, D., Zeffiro, A., 2014, ESR response of phenol compounds for dosimetry of gamma photon beams. Nuclear Instruments and Methods in Physics Research B, 339,15-19.
  • Yurus, S., Ozbey, T., Korkmaz, M., 2004, ESR investigation of gamma irradiated sulbactam sodium. Journal of Pharmaceuitcal and Biomedical Analysis, 35, 971-978.
  • Tuner, H., Korkmaz, M., 2007, Radiostability of butylated hydroxytoluene (BHT): an ESR study. Beam Interactions with Materials and Atoms, 258, 388-394.
  • Basly, J.P., Longy, I., Bernard, M., 1998c, Radiosterilization dosimetry by electron-spin resonance spectroscopy: Cefotetan. AnalyticaChimicaActa, 359, 107-113.

Işınlama Dozunun ve Depolama Süresinin Gama ile Işınlanmış Sülfapridinin Sinyal Şiddeti Üzerine Etkisi

Yıl 2016, Cilt: 3 Sayı: 3, 0 - 0, 30.09.2016
https://doi.org/10.31202/ecjse.258565

Öz

İlaçların gama enerjisi kullanılarak sterilizasyonuna olan ilgi artmaktadır. Ancak radyasyon yüksek
enerjisinden dolayı örnekte moleküler yıkımlara sebep olabilmekte ve bu durum örnekte serbest radikaller
oluşturabilmektedir. Bu çalışmanın amacı; belirli dozlarda ışınlanan sülfapridinin (SU) radyasyon duyarlılığını
EPR spektroskopisi kullanarak belirlemektir. Işınlanmamış örneğin elde edilen EPR spektrumlarında hiç bir EPR
sinyali gözlenmezken; gama ışınları ile ışınlanmanın ardından, artan ışınlama dozuna bağlı olarak belirgin EPR
sinyalleri elde edildi. Örneğin artan radyasyon dozuna bağlı sinyal şiddetindeki artışı tanımlayan matematiksel
denklemler ve korelasyon katsayıları hesaplandı. 15 kGy ışınlanmış örneğin belirli aralıklarla spektrumları
kaydedilerek ışınlama işleminden sonra oluşan serbest radikallerin kararlılığı incelendi. Sonuçların mevcut
literatür verileri ile uyum içinde olduğu tespit edildi.

Kaynakça

  • Gopal, N.G.S., 1978, Radiation sterilization of pharmaceuticals and polymers. Radiation Physics and Chemistry, 12, 35-50.
  • Diehl, J.F., 2002, Food irradiation—past, present and future. Radiation Physics and Chemistry. 63, 211–215.
  • Bhat, R., Sridhar, K.R. 2011, Influence of ionizing radiation and conventional food processing treatments on the status of free radicals in lotus seeds: an EPR study. Journal of Food Composition and Analysis, 24, 563-567.
  • Ambroz, H.M., Kornacka, E.M., Marciniec, B., Przybytniak, G., 2002, Radical decay in irradiated drugs: Flutamide, ifosamide and aminglutethimide. Journal of Radioanalytical and Nuclear Chemistry, 254, 293-298.
  • Basly, J.P., Basly, I., Bernard, M., 1998a, Electron spin resonance detection of radiosterilization of pharmaceuticals: application to four nitrofurans. The Analyst, 123, 1753-1756.
  • Basly, J.P., Bernard, M., 1997, Radiosterilization dosimetry by ESR spectroscopy: ritodrine hydrochloride and comparison with other sympathomimetics. International Journal of Pharmaceutics, 149, 85-91.
  • Delincee, H., 2002. Analytical methods to identify irradiated food—a review.Radiation Physics and Chemistry, 63, 455–458.
  • Murrieta, H., Munoz, E., Adem, E., Burillo, G., Vazquez, M., Cabrera, E., 1996. Effect of irradiation dose, storage time and temperature on the ESR signal in irradiated oat, corn and wheat.Applied Radiation and Isotopes, 47, 1657-1661.
  • Ambroz, H.B., Kornacka, E.M., Marciniec, B., Ogrodowczyk, M., Przybytniak, G.K., 2000, EPR study of free radicals in some drugs γ-irradiated in the solid state. Radiation Physics and Chemistry, 58, 357-366.
  • Rajendiran, N., Siva, S., Saravanan,J., 2013, Inclusion complexation of sulfapyridine with a- and b-cyclodextrins:Spectral and molecular modeling study. Journal of Molecular Structure, 1054-1055, 215-222.
  • Challis, J.K., Carlson, J.C., Friesen, K. J., Hanson, M.K., Wong, C.S.,2013, Aquatic photochemistry of the sulfonamide antibiotic sulfapyridine. Journal of Photochemistry and Photobiology A: Chemistry, 262, 14-21.
  • Damian, G., 2003, EPR investigation of γ-irradiated anti-emetic drugs. Talanta, 60, 923-927
  • Polat, M, Korkmaz, M (2006), Journal of Pharmaceutical and Biomedical Analysis, 40: 882-888.
  • Basly, J.P., Basly, I., Bernard, M., 1998b, Electron spin resonance identification of irradiated ascorbic acid: Dosimetry and influence of powder fineness. AnalyticaChimicaActa, 372, 373-378.
  • Marralle, M., Longo, A., Panzeca, S., Gallo, S., Principato, F., Tomarchio, E., Parlato, A., Buttafava, A., Dondi, D., Zeffiro, A., 2014, ESR response of phenol compounds for dosimetry of gamma photon beams. Nuclear Instruments and Methods in Physics Research B, 339,15-19.
  • Yurus, S., Ozbey, T., Korkmaz, M., 2004, ESR investigation of gamma irradiated sulbactam sodium. Journal of Pharmaceuitcal and Biomedical Analysis, 35, 971-978.
  • Tuner, H., Korkmaz, M., 2007, Radiostability of butylated hydroxytoluene (BHT): an ESR study. Beam Interactions with Materials and Atoms, 258, 388-394.
  • Basly, J.P., Longy, I., Bernard, M., 1998c, Radiosterilization dosimetry by electron-spin resonance spectroscopy: Cefotetan. AnalyticaChimicaActa, 359, 107-113.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Kerem Sütçü

Yayımlanma Tarihi 30 Eylül 2016
Gönderilme Tarihi 27 Nisan 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 3 Sayı: 3

Kaynak Göster

IEEE K. Sütçü, “Effect of Irradiation Dose and Storage Time on the EPR Signal Intensities of Gamma Irradiated Sulfapyridine”, El-Cezeri Journal of Science and Engineering, c. 3, sy. 3, 2016, doi: 10.31202/ecjse.258565.

Cited By

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