2-Amino-tiyazol Grubu İçeren 5-Florourasil Dimerinin Klik Tepkimesi Yoluyla Sentezi

Yıl 2021, Cilt: 8 Sayı: 1, 315 - 332, 31.01.2021

Gizem Öztürkoğlu Emriye Ay Hüseyin Alp Kadir Ay

https://doi.org/10.31202/ecjse.789749

Öz

Kanserin dünyada insan ölümlerinin nedeni olan hastalıkların başında olmasından dolayı, antikanser ya da daha az yan etkili yeni bileşiklerin sentezi oldukça önemlidir. 5-Florourasil (5-FU) kemoterapi için kullanılan bileşiklerin en eskilerinden biridir. Bu çalışmada, potansiyel antikanser özelliklerine sahip 1,2,3-triazol köprüsü içeren bileşik 4, moleküler hibridizasyon yaklaşımı kullanılarak 5-FU ve 2-aminotiyazolün klik tepkimesi yoluyla sentezlendi. Yeni bileşiğin yapı aydınlatması, FTIR, 1H, 13C, 19F, COSY, HSQC, HMBC ve TOF-MS gibi modern spektroskopik yöntemler kullanılarak gerçekleştirildi.

Anahtar Kelimeler

5-FU, klik tepkimesi, triazol, antikanser, moleküler hibridizasyon

Synthesis of 5-Fluorouracil Dimer Containing 2-Amino-thiazole Group via Click Reaction

Öz

Since cancer is one of the leading diseases that cause human deaths in the world, the synthesis of anticancer or new compounds with fewer side effects is important. 5-Fluorouracil (5-FU) is one of the oldest compounds used for chemotherapy. In this study, 1,2,3-triazole bridge containing compound 4, which could have potential anticancer properties, was synthesized via the click reaction from the 5-FU and 2-aminothiazole using the molecular hybridization approach. The structural elucidation of the new compound was carried out using modern spectroscopic methods such as FTIR, 1H, 13C, 19F, COSY, HSQC, HMBC and TOF-MS.

Anahtar Kelimeler

5-FU, click reaction, triazole, anticancer, molecular hybridization

Kaynakça

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