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Transrektal Biyopsi Sonrası Gelişen Enfeksiyonlarda Konakçı Faktörünün Önemi

Yıl 2019, , 52 - 55, 03.08.2019
https://doi.org/10.33713/egetbd.550138

Öz

Amaç:
Transrektal ultrasonografi eşliğinde yapılan prostat biyopsi (TRUSPB) sonrası
gelişen enfeksiyonlarda konakçı faktörünün etkisini ve önemini araştırdık.



Gereç ve Yöntem:
Mart 2016 ile Mart 2018 arasında TRUSPB yapılan 250 hasta çalışmaya dahil
edildi. Tüm hastalardan TRUSPB sırasında doku kültürü ve biyopsi sonrası 3.
günde idrar kültürü alındı. Doku kültüründe üreme olmasının biyopsi sonrası
ateşe ve toplam enfeksiyon oranına etkisi araştırıldı. Ayrıca doku kültüründe
üreme olan hastalarda ateş gelişme oranına bakıldı. Böylece konakçı faktörünün
etkisi anlaşılmaya çalışıldı.



Bulgular:
Toplam 78 hastanın (%31,2) doku kültüründe üreme oldu. Biyopsi sonrası 18
hastada (%7,2) ateş yüksekliği saptandı. 40 hastada (%16) enfeksiyöz komplikasyon
gelişti. Doku kültüründe üreme olmasının biyopsi sonrası ateş gelişiminde ve
toplam enfeksiyöz komplikasyon gelişiminde istatistiksel olarak anlamlı etkisi
olduğu görüldü.



Ateş
yüksekliği olan 18 hastanın 13’ünde(%78) doku kültüründe üreme saptandı.
Enfeksiyöz komplikasyon gelişen 40 hastanın 24’ünde(%60) doku kültüründe üreme
saptandı. Ancak doku kültüründe üreme olan hastaların sadece 13’ünde (%16,6)
ateş yüksekliği saptandı. Yine doku kültüründe üreme olanların 24’ünde (%30,7)
enfeksiyöz komplikasyon gelişti.



Sonuç: Doku kültüründe üreme olması ile biopsi sonrası
ateş yüksekliği ve toplam enfeksiyöz komplikasyon gelişmesi açısından anlamlı
bir ilişki saptanmıştır. Ancak doku kültüründe üreme olan hastaların büyük
çoğunluğunda ateş yüksekliği olmaması ve doku kültüründe üreme olmayan
hastaların bazılarında ateş yüksekliği olması konakçıya ait ek faktörlerin
etkisi olduğunu düşündürmektedir.

Kaynakça

  • 1- Loeb S, Carter HB, Berndt SI, et al. Complications after prostate biopsy: data from SEER-Medicare. J Urol. 2011; 186:1830–1834.
  • 2- Wolf JS Jr, Bennett CJ, Dmochowski RR, et al. Best practice policy statement on urologic surgery antimicrobial prophylaxis. J Urol. 2008; 179:1379–1390.
  • 3- E. L. Zani,O.A.C.Clark, and N. RodriguesNetto Jr., “Antibiotic prophylaxis for transrectal prostate biopsy,” Cochrane Database of Systematic Reviews, 2011;vol. 5.
  • 4- Liss MA, Nakamura KK, Meuleners R, Kolla SB, Dash A, Peterson EM. Screening Rectal Culture to Identify Fluoroquinolone-resistant Organisms Before Transrectal Prostate Biopsy: Do the Culture Results Between Office Visit and Biopsy Correlate? Urology. 2013; 82(1): 67–71.
  • 5- Chung HS, Hwang EC, Yu HS, Jung SI, Lee SJ, Lim DH, Cho WJ, Choe HS, Lee SJ, Park SW.Prevalence of fluoroquinoloneResistant rectal flora in patients undergoing transrectalultrasound-guided prostate needle biopsy: A prospective multicenter study. Int J Urol. 2018 Mar;25(3):278-283.
  • 6- Summers SJ, Patel DP, Hamilton BD, Presson AP, Fisher MA, Lowrance WT, Southwick AW. An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy. World J Urol (2015) 33:2001–7.
  • 7- Zaytoun OM, Vargo EH, Rajan R, et al. Emergence of fluoroquinolone-resistant Escherichia coli as cause of postprostate biopsy infection: implications for prophylaxis and treatment. Urology. 2011;77:1035–1041.
  • 8- Madden T, Doble A, Aliyu SH, Neal DE. Infective complications after transrectal ultrasoundguided prostate biopsy following a new protocol for antibiotic prophylaxis aimed at reducing hospital-acquired infections. BJU Int. 2011; 108:1597–602.
  • 9- Turk H, Un S, Sener GA, Yoldas M, Akdeniz F, Arslan E. Prostate Biopsy to Diagnose Acute Bacterial Prostatitis: Current Microbiological Spectrum, Sensitivity to Antibiotics, and Clinical Findings in Turkey. EJMO 2018;2(2):91-6.
  • 10- Z. Abughosh, J. Margolick, S. L. Goldenberg et al. A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy. The Journal of Urology, 2013;189:1326–31.
  • 11- Dai J, Leone A, Mermel L, Hwang K, Pareek G, Schiff S, Golijanin D, Renzulli JF. Rectal swab culture-directed antimicrobial prophylaxis for prostate biopsy and risk of postprocedure infection: a cohort study. Urology 2015;85(1):8–14.
  • 12- Hamarat MB, Tarhan F, Horuz R, Öcal GA, Demirkol MK, Alper Kafkaslı A, Yazıcı Ö. Infective complications in patients after transrectal ultrasound-guided prostate biopsy and the role of ciprofloxacin resistant Escherichia coli colonization in rectal flora. Turk J Urol 2017; 43(2): 210-5.
  • 13- Liss MA, Taylor SA, Batura D et al. Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy. J. Urol. 2014; 192: 1673–8.
  • 14- Boeri L, Fontana M, Gallioli A et al. Rectal culture-guided targeted antimicrobial prophylaxis reduces the incidence of post-operative infectious complications in men at high risk for infections submitted to transrectal ultrasound prostate biopsy – results of a cross-sectional study. PLoS One 2017; 12.
  • 15- Benli E, Cirakoglu A, Ogreden E, Cetinkol Y, Calgin MK, Ayyildiz A, Yüce A. Does Leaving the Biopsy Needle in Povidone-Iodine Solution Reduce Infective Complications after Biopsy? Advances in Urology, 2016;5.

The Importance of the Host Factor in Infections Following Transrectal Biopsy

Yıl 2019, , 52 - 55, 03.08.2019
https://doi.org/10.33713/egetbd.550138

Öz

Objective:
We
investigated the effect and significance of the host factor in infections
following transrectal ultrasound-guided prostate biopsy.

Material
and Methods: 
A
total of 250 patients who underwent transrectal ultrasound-guided prostate
biopsy between March 2016 and March 2018 were included in the study. The effects of positive tissue culture
on post-biopsy fever and also on total infection rate were investigated. So, the effect of the host factor was
tried to be clarified.

Results:A
total of 78 patients (31.2%) had growth in tissue culture.  Infectious complications developed in 40
patients (16%) Growth in tissue culture 
showed a statistically significant effect on the development of fever
and total infectious complications after biopsy. However, only 13 (16,6%) of
the patients who had tissue culture had a fever.







Conclusion:
A significant relationship was found between growth in tissue culture and
development of fever and total infectious complications following biopsy.
However, the fact that the majority of the 
patients with positive tissue culture had no fever whereas some of the
patients with negative tissue culture had fever may suggest that there might be
some additional effects of host-related factors.

Kaynakça

  • 1- Loeb S, Carter HB, Berndt SI, et al. Complications after prostate biopsy: data from SEER-Medicare. J Urol. 2011; 186:1830–1834.
  • 2- Wolf JS Jr, Bennett CJ, Dmochowski RR, et al. Best practice policy statement on urologic surgery antimicrobial prophylaxis. J Urol. 2008; 179:1379–1390.
  • 3- E. L. Zani,O.A.C.Clark, and N. RodriguesNetto Jr., “Antibiotic prophylaxis for transrectal prostate biopsy,” Cochrane Database of Systematic Reviews, 2011;vol. 5.
  • 4- Liss MA, Nakamura KK, Meuleners R, Kolla SB, Dash A, Peterson EM. Screening Rectal Culture to Identify Fluoroquinolone-resistant Organisms Before Transrectal Prostate Biopsy: Do the Culture Results Between Office Visit and Biopsy Correlate? Urology. 2013; 82(1): 67–71.
  • 5- Chung HS, Hwang EC, Yu HS, Jung SI, Lee SJ, Lim DH, Cho WJ, Choe HS, Lee SJ, Park SW.Prevalence of fluoroquinoloneResistant rectal flora in patients undergoing transrectalultrasound-guided prostate needle biopsy: A prospective multicenter study. Int J Urol. 2018 Mar;25(3):278-283.
  • 6- Summers SJ, Patel DP, Hamilton BD, Presson AP, Fisher MA, Lowrance WT, Southwick AW. An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy. World J Urol (2015) 33:2001–7.
  • 7- Zaytoun OM, Vargo EH, Rajan R, et al. Emergence of fluoroquinolone-resistant Escherichia coli as cause of postprostate biopsy infection: implications for prophylaxis and treatment. Urology. 2011;77:1035–1041.
  • 8- Madden T, Doble A, Aliyu SH, Neal DE. Infective complications after transrectal ultrasoundguided prostate biopsy following a new protocol for antibiotic prophylaxis aimed at reducing hospital-acquired infections. BJU Int. 2011; 108:1597–602.
  • 9- Turk H, Un S, Sener GA, Yoldas M, Akdeniz F, Arslan E. Prostate Biopsy to Diagnose Acute Bacterial Prostatitis: Current Microbiological Spectrum, Sensitivity to Antibiotics, and Clinical Findings in Turkey. EJMO 2018;2(2):91-6.
  • 10- Z. Abughosh, J. Margolick, S. L. Goldenberg et al. A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy. The Journal of Urology, 2013;189:1326–31.
  • 11- Dai J, Leone A, Mermel L, Hwang K, Pareek G, Schiff S, Golijanin D, Renzulli JF. Rectal swab culture-directed antimicrobial prophylaxis for prostate biopsy and risk of postprocedure infection: a cohort study. Urology 2015;85(1):8–14.
  • 12- Hamarat MB, Tarhan F, Horuz R, Öcal GA, Demirkol MK, Alper Kafkaslı A, Yazıcı Ö. Infective complications in patients after transrectal ultrasound-guided prostate biopsy and the role of ciprofloxacin resistant Escherichia coli colonization in rectal flora. Turk J Urol 2017; 43(2): 210-5.
  • 13- Liss MA, Taylor SA, Batura D et al. Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy. J. Urol. 2014; 192: 1673–8.
  • 14- Boeri L, Fontana M, Gallioli A et al. Rectal culture-guided targeted antimicrobial prophylaxis reduces the incidence of post-operative infectious complications in men at high risk for infections submitted to transrectal ultrasound prostate biopsy – results of a cross-sectional study. PLoS One 2017; 12.
  • 15- Benli E, Cirakoglu A, Ogreden E, Cetinkol Y, Calgin MK, Ayyildiz A, Yüce A. Does Leaving the Biopsy Needle in Povidone-Iodine Solution Reduce Infective Complications after Biopsy? Advances in Urology, 2016;5.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Orijinal Araştırma
Yazarlar

Erkan Arslan 0000-0002-3262-2512

Hakan Türk 0000-0002-4559-301X

Sıtkı Ün Bu kişi benim 0000-0003-1477-7497

Pınar Şamlıoğlu Bu kişi benim 0000-0002-8491-7777

Yayımlanma Tarihi 3 Ağustos 2019
Kabul Tarihi 16 Mayıs 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

EndNote Arslan E, Türk H, Ün S, Şamlıoğlu P (01 Ağustos 2019) The Importance of the Host Factor in Infections Following Transrectal Biopsy. Ege Tıp Bilimleri Dergisi 2 2 52–55.

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