Alysicarpus vaginalis (L.) DC. ekstrelerinin farmakolojik özellikleri

Öz

AMAÇ: Bu sistematik derlemenin amacı, A. vaginalis ile bağlantılı yayınlanmış çalışmaların farmakolojik özelliklerini analiz etmek, özetlemek ve belgelemek. GEREÇ VE YÖNTEM: Bu ileriye dönük çalışmada, 1900'den Temmuz 2021'e kadar yayınlanmış uygun makaleleri tanımak için Elektronik kayıtlar (PubMed, Semantic Scholar, Scopus, ScienceDirect ve Web of Science) kullanılmıştır. SONUÇLAR: Şimdiye kadar, in vivo ve in vivo Bu bitki türlerinin farmakolojik özellikleri için vitro bilimsel kanıtlar mevcuttur. A. vaginalis'in çeşitli kısımlarının antibakteriyel, antikanser, antifungal, antioksidan ve hepatoprotektif özellikleri tespit edilmiştir. Dikkat çekici bir şekilde, hiçbir farmakolojik aktif bileşik izole edilmemiştir ve bu bitki türlerinin geleneksel tıbbi kullanımı için herhangi bir bilimsel kanıt bulunmamaktadır. SONUÇ: Bu çalışma, A. vaginalis'in bildirilen farmakolojik özelliklerini analiz etmiş, özetlemiş ve belgelemiştir.

Anahtar Kelimeler

• Alysicarpus vaginalis
• Fabaceae
• Siddha Medicine
• Sri Lanka
• Antioksidan özellik

Pharmacological properties of extracts of Alysicarpus vaginalis (L.) DC.

Öz

OBJECTIVE: This systematic review was aimed to analyze, summarize, and document the pharmacological properties of published studies linked to A. vaginalis. MATERIALS AND METHODS: In this prospective study, Electronic records (PubMed, Semantic Scholar, Scopus, ScienceDirect, and Web of Science) were utilized to recognize the appropriate existing published articles from 1900 to July 2021. RESULTS: Until now, in vivo and in vitro scientific evidence exists for the pharmacological properties of this plant species. Antibacterial, anticancer, antifungal, antioxidant, and hepatoprotective properties of various parts of A. vaginalis have been detected. Remarkably, no pharmacological active compound has been isolated and there is no scientific evidence available for any of the traditional medicinal use of this plant species. CONCLUSION: This work analyzed, summarized, and documented the reported pharmacological properties of A. vaginalis.

Anahtar Kelimeler

• Alysicarpus vaginalis
• Fabaceae
• Siddha Medicine
• Sri Lanka
• Antioxidant property

Kaynakça

1. 1. Kew Science. Alysicarpus vaginalis (L.) DC. Plants of the World Online. 2021. Available from: http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:473569-1 (Accessed 30.06.21).
2. 2. Burkill HM. The useful plants of west tropical African. 1995. Royal Botanic Gardens, Kew.
3. 3. Ediriweera EA. Review on Medicinal uses of Weeds in Sri Lanka. Tropical Agricultural Research and Extension. 2010; 10: 11–16. https://doi.org/10.4038/tare.v10i0.1865
4. 4. Kirtikar KR, Basu BD. Indian medicinal plants, Vol 11. Lalit Mohan Basu, Allahabad. 1935: 1347-1348.
5. 5. Vivekanandarajah S, Rajamanoharan PR, Heinrich M, Munday M. Preparations and plants used to treat diabetes in Sri Lankan Siddha Medicine. Presented at the 3rd International Conference on Ayurveda, Unani, Siddha and Traditional Medicine, Institute of Indigenous Medicine, University of Colombo, Colombo. 2015; 67.
6. 6. Vivekanandarajah S, Rajamanoharan PRS, Munday M, Heinrich M. Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources. Journal of Ethnopharmacology. 2016; 198: 531–599. https://doi.org/10.1016/j.jep.2016.07.053
7. 7. Vivekanandarajah S, Rajamanoharan P, Munday M, Heinrich M. Plants currently used to treat diabetes in Sri Lankan Siddha Medicine – an ethnobotanical survey in the Eastern Province. Presented at the World Congress Integrative Medicine & Health 2017: part three, Springer Nature, Berlin, Germany. 2017; 333. https://doi.org/10.1186/s12906-017-1784-2
8. 8. Vivekanandarajah S, Rajamanoharan PRS, Heinrich M. Siddha Medicine in Eastern Sri Lanka Today–Continuity and Change in the Treatment of Diabetes. Front. Pharmacol. 2018; 9: 1022. https://doi.org/10.3389/fphar.2018.01022

9. 9. Tirkey A. Some ethnomedicinal plants of family-Fabaceae of Chhattisgarh state. Indian Journal of Traditional Knowledge. 2006; 5: 551–553.
10. 10. Rajamanoharan, P., Vivekanandarajah, S. The role of honey in pediatric treatments in Sri Lankan Siddha Medicine. Uludag Bee Journal. 2021; 21: 83–90. https://doi.org/10.31467/uluaricilik.851567
11. 11. Vivekanandarajah S. Antidiabetic plants used by Sri Lankan Tamils. Jaffna Science Association Newsletter. 2021; 28 (3): 3.
12. 12. Vivekanandarajah S. நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 1 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 1). Valampurii Newspaper 2021.
13. 13. Vivekanandarajah S. நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 2 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 2). Valampurii Newspaper 2021.
14. 14. Vivekanandarajah S. நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 3 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 3). Valampurii Newspaper 2021.
15. 15. Vivekanandarajah S. Plants historically used by Sri Lankan Tamils to treat diabetes. Presented at The International Dr. Safiye Ali Multidisciplinary Studies Congress in Health Sciences, İzmir, Turkey, August 2021.
16. 16. Vivekanandarajah S. Plants used to treat diabetes in Sri Lankan Siddha Medicine (Ph.D. Thesis). University College London, London, UK. 2018.
17. 17. Vivekanandarajah S. Plants historically used to treat diabetes in Sri Lankan Siddha Medicine. Presented at the International Seminar & Exhibition on Phytopharmaceuticals: Emerging Challenges and Opportunities, Ooty, India. 2017.
18. 18. Vivekanandarajah S. Plants with Anti-Diabetes Mellitus Properties, 591, Appian Subramoniam, CRC Press (Taylor & Francis Group), Boca Raton (FL, USA). Journal of Ethnopharmacology. 2016; 191: 19–20. https://doi.org/10.1016/J.JEP.2016.06.031
19. 19. Liu H, Lei M, Liang X, Jiang Z, Guo X. Simultaneous determination of three purines in Alysicarpus vaginalis (L.) DC. by hollow fiber-based liquid-phase microextraction combined with high-performance liquid chromatography. Biomedical Chromatography. 2014; 28: 311–316. https://doi.org/10.1002/bmc.3022
20. 20. Nandhu M, Abhirami V, Sukanya S, Prabin J, Mary Helen P. Phytochemical Analysis and Antioxidant Activity of Leaf Extracts of Alysicarpus vaginalis . Journal of emerging technologies and innovative research. 2018; 5: 615–621.
21. 21. Tapadiya G, Kale MA, Saboo S. Phytochemical characterization, anti-cancer and antimicrobial activity of isolated fractions of Alysicarpus vaginalis . Bangladesh Journal of Pharmacology. 2017; 12: 77–83.
22. 22. Arya P, Mehta JP. Antioxidant Potential of Himalayan Medicinal Plants Angelica glauca, Alysicarpus vaginalis and Peristrophe bicalyculata. International Journal of Current Microbiology and Applied Sciences. 2017; 6: 1892–1901. https://doi.org/10.20546/ijcmas.2017.607.226
23. 23. Kurian S, Joseph L, Josekumar VS. PHYTOCHEMICAL ANALYSIS AND IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF SUCCESSIVE EXTRACTS OF ALYSICARPUS VAGINALIS VAR. NUMMULARIFOLIUS (DC.) MIQ. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9: 231–234. https://doi.org/10.22159/ijpps.2017v9i6.16814
24. 24. Kurian S, Josekumar VS. PHYTOCHEMICAL SCREENING, ANTIMICROBIAL ACTIVITY AND BRINE SHRIMP LETHALITY BIOASSAY OF DIFFERENT EXTRACTS OF ALYSICARPUS VAGINALIS VAR. NUMMULARIFOLIUS (DC.) MIQ. (FAMILY: FABACEAE). International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9: 1–6. https://doi.org/10.22159/ijpps.2017v9i1.15688
25. 25. Rathi MA, Meenakshi P, Gopalakrishnan VK. Hepatoprotective activity of ethanolic extract of Alysicarpus vaginalis against nitrobenzene-induced hepatic damage in rats. South Indian Journal of Biological Sciences. 2015; 1: 60–65.
26. 26. Rattanata N, Daduang S, Phaetchanla S, Bunyatratchata W, Promraksa B, Tavichakorntrakool R, Uthaiwat P, Boonsiri P, Daduang J. Antioxidant and antibacterial properties of selected Thai weed extracts. Asian Pacific Journal of Tropical Biomedicine. 2014; 4: 890–895. https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0422
27. 27. Sakle NS, More SA, Mokale SN. Chemomodulatory effects of Alysicarpus vaginalis extract via mitochondria-dependent apoptosis and necroptosis in breast cancer. Nutrition and Cancer. 2020; 72: 1243–1253. https://doi.org/10.1080/01635581.2019.1670855