Short-Term Efficacy of Intraarticular Hyaluronic Acid Injection in Gonarthrosis

Yıl 2019, Cilt: 2 Sayı: 3, 101 - 107, 20.12.2019

Nilay Şahin , Serdar Sargın , Fatih Cesme Demirhan Dıraçoğlu Cihan Aksoy

https://doi.org/10.33713/egetbd.588375

Öz

Introduction:

Gonarthrosis is a chronic, degenerative disease that causes pain
and stiffness. There
are many treatment methods defined as conservative and surgical. Intra-articular
hyaluronic acid injection is one of these methods. There are different
preparations routinely used in the treatment. There is no clear evidence of
which is more effective. We aimed to investigate the effectiveness of HA
preparations with different molecular weights on pain and functionality of
patients with gonarthrosis.

 

Material and Methods

30 of 55 patients (ranging
40-80 years old) diagnosed  as bilateral
gonarthrosis were enrolled in the study. Patients were randomly divided into 3 groups
(Hyalgan (N = 10), Orthovics (N = 10), Synvisc (N = 10)). Patients were
evaluated before and after treatment. Clinical examination, Visual Analogue
Scale, WOMAC score, stiffness and physical condition, 15 m walking time and 15
steps up and down performance were evaluated.

 

Results

             There
was no significant difference between the groups in terms of age, body mass
index (BMI) and symptom duration (p: 0.917, p: 0.721, p: 0.519, respectively).
In all three groups, pre-treatment VAS scores (motion, rest and night)
significantly decreased after treatment (p <0.001). According to WOMAC
results, pain, stiffness decreased significantly after treatment (p <0.001).
There was no significant difference between the groups in any parameter (p>
0.05).

Conclusion

The results of this study revealed no
statistically significant difference between HA preparations in WOMAC and VAS
scores; However, HA has been found to be effective and should be used in the
treatment of early stage gonarthrosis.

Anahtar Kelimeler

Hyaluronic acid, injection, Gonarthrosis, Molecular weight

Gonartrozda İntra-artiküler Hyalüronik Asid Enjeksiyonunun Kısa Dönem Etkinliği

Öz

Giriş:

Gonartroz, ağrı ve sertliğe neden olan kronik, dejeneratif bir hastalıktır. Konservatif ve cerrahi olarak tanımlanan birçok tedavi yöntemi vardır. Eklem içi hyaluronik asit enjeksiyonu bu yöntemlerden biridir. Tedavide rutin olarak kullanılan farklı preparatlar vardır ve hangisinin daha etkili olduğuna dair net bir kanıt yok. Farklı molekül ağırlıklarına sahip HA preparatlarının gonartrozu olan hastaların ağrı ve işlevselliği üzerine etkilerini araştırmayı amaçladık.

Gereç ve Yöntem

İki taraflı gonartroz tanısı konan 55 hastanın 30'u (40-80 yaşları arasında) çalışmaya alındı. Hastalar rastgele 3 gruba ayrıldı (Hyalgan (N = 10), Ortez (N = 10), Synvisc (N = 10)). Hastalar tedaviden önce ve sonra değerlendirildi. Klinik muayene, Görsel Analog Skala, WOMAC skoru, sertlik ve fiziksel durum, 15 m yürüme süresi ve 15 basamak yukarı ve aşağı performans değerlendirildi.

Bulgular

Gruplar arasında yaş, vücut kitle indeksi (BKİ) ve semptom süresi açısından anlamlı fark yoktu (sırasıyla p: 0.917, p: 0.721, p: 0.519). Her üç grupta da tedavi öncesi VAS skorları (hareket, dinlenme ve gece) tedaviden sonra anlamlı olarak azaldı (p <0.001). WOMAC sonuçlarına göre tedaviden sonra ağrı, sertlik belirgin olarak azaldı (p <0.001). Herhangi bir parametrede gruplar arasında anlamlı fark bulunmadı (p> 0.05).

Sonuç

Bu çalışmanın sonuçları, WOMAC ve VAS skorlarındaki HA preparatları arasında istatistiksel olarak anlamlı bir fark olmadığını ortaya koydu; Bununla birlikte, HA'nın etkili olduğu ve erken evre gonartroz tedavisinde kullanılması gerektiği bulunmuştur.

Anahtar Kelimeler

Hyaluronik asit, enjeksiyon, Gonartroz, Moleküler ağırlık

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