İnvestigation of the Efficacy of Aminoguanidine in an Experimental Rat Model with Isolated Bilateral Pulmonary Contusion Due To Blunt Thoracic Trauma

Year 2019, Volume: 1 Issue: 3, 115 - 120, 23.12.2019

Dilek Atik , Bengu Seliman Derya Balcı Koroglu Bensu Bulut , Bahadır Taslıdere

Abstract

İntroduction: In severe
thoracic trauma pulmonary contusions are almost inevitable are associated with
high morbidity and mortality. In this study we aimed to evaluate the
antioxidant activity of aminoguanidine in pulmonary contusion.

Method:
Sixty-three Sprague-male rats were used. Sham and aminoguanidine groups were
exposed to isolated blunt thoracic trauma with a force of 1,512 joules.
Aminoguanidine was administered intraperitoneally at a dose of 100 mg/kg 3
hours before the trauma and on the 1. and 2. day after the trauma. The
contusion group was exposed to blunt thoracic trauma only. In all groups,
arterial blood gas analysis and catalase and NO levels were done on the 0th,
1st, 2nd and 3rd days.

Results: PO2 levels
were higher in the sham group compared to the contusion group, without
statistical significance. On the third day, SaO2 levels were higher in the AG
group compared to the contusion group. SaO2 levels were comparable in the AG
and sham groups on days 1, 2 and 3. There was no difference between the PaO2
levels of the contusion and sham groups on the 2nd and 3rd days. There was no difference
between the PaO2 levels of the AG and sham groups on the 1st, 2nd and 3rd days.
We found no difference between the PaCO2 levels of the contusion and sham
groups on the 0-3 days. There was no difference between the PaCO2 levels of the
AG and sham groups on the 1st, 2nd and 3rd days. No difference was observed
between the PaCO2 levels of the AG and contusion groups on the 1st, 2nd and 3rd
days. No significant difference was found between the NO levels of the sham and
the contusion groups on day 0. There was a significant difference between the
sham and contusion groups on the 1st, 2nd and 3rd days. There was no
statistically significant difference between the catalase enzyme activities of
the sham and AG groups.

Conclusion: In our
study, we showed that the use of aminoguanidine did not significantly reduce
the severity of pulmonary contusion and the inflammatory reaction induced by
thoracic trauma in rats.

Keywords

Blunt Thoracic Trauma, Aminoguanidine, Catalase activity

Supporting Institution

Diskapi Education and Research Hospital

Project Number

09.05.2011-23

Thanks

This study was supported by a project (09.05.2011-23) from the project is supported by Diskapi education and research hospital. Ankara, Turkey.

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