A Giant Hamartoma of Tuber Cinerium: Conventional MRI Imaging and MR Spectroscopy Findings

Abstract

Hypothalamic hamartoma is a developmental malformation in the region of tuber cinereum and mamillary bodies. It presents the most commonly detectable lesion in patients with precocious puberty and is associated with gelastic seizures. As well as, it can be completely silent to be found only incidentally. Computed tomography (CT) and magnetic rezonans (MR) imaging are preferred imaging modalities in diagnose of hypothalamic hamartomas. The aim of this study is to present the radiologic imaging findings of a rare hypothalamic hamartoma case.

Keywords

• Hypothalamic hamartoma, giant, tuber cinerium, MR imaging, spectroscopy

A Giant Hamartoma of Tuber Cinerium: Conventional MRI Imaging and MR Spectroscopy Findings

Öz

Hipotalamik hamartoma tuber sineryum bölgesinde ve mamilalar cisimciğinin bir gelişimsel anomalisidir. Bu yaygın olarak puberte öncesi dönemde saptanabilmekte ve gelastic nöbetler ile ilişkilidir. Tamamen sessiz olabilir. ve tesadüfen tespit edilebilir. Bilgisayarlı tomografi (BT) ve manyetik rezonans (MR) görüntüleme hipotalamik hamartomların tanısında görüntüleme yöntemleri olarak tercih edilmektedir. Bu çalışmanın amacı nadir bir hipotalamik hamartomu olgusunun radyolojik görüntüleme bulgularını sunmaktır

Anahtar Kelimeler

• Hipotalamik hamartom, dev, tuber sineryum, MR bulguları, spektroskopi

Kaynakça

1. Branberg G, Raininko R, Eeg-Olofson O. Hipothalamic hamartoma with gelastic seizures in Swedish children and adolescents. Eur J Paediatr Neurol 2004;8:35-44.
2. Ng SM, Kumar Y, Cody D, Smith CS, Didi M. Cranial MRI scans are indicated in all girls with central precocious pu- berty. Arch Dis Child 2003;88:414-41.
3. Yamaguchi S, Suzuki SO, Matsuo Y, et al. Large hypotha- lamic hamartoma with calcification and cystic components in an adult-case report. Neurol Med Chir 2010;50:495-8.
4. Boyko OB, Curnes JT, Oakes WJ, Burger PC. Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol 1991;12:309-14.
5. Berkovic SF, Andermann F, Melanson D, Ethier RE, Feindel W, Gloor P Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diag- nostic value of magnetic resonance imaging. Ann Neurol 1988;23:429-39.
6. Alkan O, Kizilkilic O, Karsantiozu T. Clinical Manifestations and MR Imaging Features In Hypothalamic Hamartomas. J Neurol Sci [Turk] 2009;26:335-342
7. Shah P, Patkar D, Patankar T, Shah J, Srinivasa P, Krishnan A. MR imaging features in hypothalamic hamartoma: a report of three cases and review of literature J Postgrad Med 1999; 45:84-6.
8. Boudreau EA, Liow K, Frattali CM, et al. Hypothalamic hamartomas and seizures: distinct natural history of isolated and Pallister-Hall syndrome cases Epilepsia 2005;46:42-7