Extra-cutaneous Palatal Malignant Melanoma in Middle -Aged Females

Öz

Ağız boşluğunun malign melanoması özellikle yaşlı erkekleri etkileyen nadir görülen bir agresiv tümördür. 21 yıllık ağız boşluğu malign melanomasıdeğerlendirildi. Yaş aralığı 27-80 yıl ve ortalaması ise 49.8 idi. Semptom süresi 2 ay ile bir yıl arasında değişmekte idi. Muayenede lenf nodu genişlemesi olan 7 olguda sert damakta lokalize değişik ölçülerde ülserasyon ve kanama gösterdi. Damak melanomaları hızlı ilerleme ve çoğu hastalar daha kötü prognoz gösterirler. Sınıflandırma ve tedavisi halen deri melanomasına göre yapılmaktadır. Erken dönem hastalık sıklıkla asemptomatiktir. Bundan dolayı klinisyenlerin agresiv tümörün mortalite ve morbiditesini azaltması için bu hastalık hakkında bilgi düzeylerini artırması gerekmektedir

Anahtar Kelimeler

• Melanom, ekstrakutenöz, kadın, damak

Extra-cutaneous Palatal Malignant Melanoma in Middle -Aged Females

Abstract

Malignant melanoma of the oral cavity is an uncommon aggressive tumour that preferentially affects elderly males. A twenty-one year analysis of oral malignant melanoma cases were evaluated. The age range was 27-80 years with a mean of 49.8 years. Symptom duration ranged from 2 months to a year. Examination revealed ulcerated and bleeding grey to black tumours of varying sizes located predominantly in the hard palate in nine cases with lymph nodes (submandibular and cervical) enlargement. Palatal melanoma has a rapid growth rate and most patients present with advanced disease which has poorer prognosis. Its classification and treatment is still based on the cutaneous disease. Early disease is often asymptomatic thus awareness and knowledge of its biological behaviour by attending clinicians will aid prompt diagnosis and also reduce morbidity and mortality of this aggressive tumour

Keywords

• Melanoma, extracutaneous, female, palate

Kaynakça

1. Bujas T, Pavic I, Prus A, Marusic Z, Balicevic D. Primary oral melanoma. A case report. Acta Clin Croat 2010; 49: 55-9.
2. Strauss JE, Strauss SI. Oral Malignant Melanoma: A case report and review of literature. J Oral Maxillofacial Surg 1994; 52: 972-6.
3. Hashemi Pour MS. Malignant melanoma of the oral cavity: a review of literature. Indian J Dent Res 2008; 19: 47-51.
4. Femiano F, Lanza A, Buonaiuto C, Gombos F, Di Spirito F, Cirillo N. Oral malignant melanoma: a review of the literature. J Oral Pathol Med 2008; 37:383-8.
5. Samaila MOA, Rafindadi AH. Pattern of Cutaneous Malignant Melanoma in Zaria, Nigeria. Ann Afr Med 2006; 5:16-9.
6. Umeda M, Komatsubara H, Shibuya Y, Yokoo S, Komori T. Premalignant melanocytic dysplasia and malignant mela- noma of the oral mucosa. Oral Oncol 2002; 38: 714-22.
7. Clark WH Jr, Elder DE, Guerry DP, Epstein M.N, Greene M.H, Van Horn M. A study of tumor progression. The pre- cursor lesions of superficial spreading and nodular mela- noma. Hum Pathol 1984; 15:1147-65.
8. McGovern VS. The classification of melanoma and its rela- tionship with prognosis. Pathology 1970; 2: 85-98.

9. Muller S. Melanin-associated pigmented lesions of the oral mucosa: presentation, differential diagnosis and treatment. Dermatol Ther 2010; 23: 220-9.
10. Powell JP, Cummings CW. Melanoma and the differential diagnosis of oral pigmented lesions. Laryngoscope 1978; 88: 1252-65.
11. Silberman AW. Malignant Melanoma. Cedars- Sinai Comprehensive Cancer Center. Cancer News on the Net.R
12. Uchiyama Y, Murakami S, Kawai T, Ishida T, Fuchihata H. Primary malignant melanoma in the oral mucosal mem- brane with metastasis in the cervical lymph node : MR Appearance. Am J Neuroradiol 1998; 19: 954-55.
13. Bartkowski SB, Panas M, Wilczanska H, Dubiel-Bigaj M. Primary Malignant Melanoma of the Oral Cavity. A review of 20 cases. Am J Surg 1984; 148:362-6.
14. McCaffrey TV, Neil HB, Gaffey TA. Malignant melanoma of the oral cavity: review of 10 cases. Laryngoscope 1980; 1329-35. 144