Abstract. Antiphospholipid syndrome is characterized by arterial or venous thrombosis and/or recurrent miscarriages together with presence of anticardiolipin antibodies and/or lupus anticoagulant and/or anti-β2-glycoprotein 1 positivity. The exact pathogenic role of antibodies in the development of thrombosis still remains to be fully elucidated. Novel mechanisms involving both the complement pathway and micro-particles have been described. This knowledge might identify novel therapeutic targets and improve the management.
Key words : Antiphospholipid syndrome, Anticardiolipin antibodies, Lupus anticoagulant, anti-β2-glycoprotein 1, Thrombosis, Heparin, Warfarin, Aspirin
| Birincil Dil | İngilizce |
|---|---|
| Yazarlar | |
| Yayımlanma Tarihi | 14 Ocak 2013 |
| Yayımlandığı Sayı | Yıl 2009 Cilt: 14 Sayı: 2 |